Top 24 Hotels In Isle Of Palms South, Florida 32250

Uncover a warm and comfy stay at Residence Inn by Marriott Jacksonville Mayo Clinic Area on your trip to Isle Of Palms South, where quality accommodations provide comfort, with inviting rates from $314.99. Benefit from Residence Inn's excellent customer service, ensuring your stay is enjoyable from check-in to checkout.

Whether walking or driving, guests staying at Residence Inn by Marriott Jacksonville Mayo Clinic Area are perfectly positioned to explore Isle Of Palms South, with the downtown area just minutes away. Choose a Isle Of Palms South hotel that transforms your visit with well-rounded, inviting amenities—lock in today!

Guests traveling to Isle Of Palms South will find inviting accommodations at TownePlace Suites by Marriott Jacksonville East, where soothing rooms start at $164.99, creating a warm and welcoming space. Marriott Bonvoy™ benefits at TownePlace Suites include exclusive rewards that enrich your travel.

At TownePlace Suites by Marriott Jacksonville East, guests are always close enough to downtown Isle Of Palms South for a quick drive, making it easy to explore the city while enjoying a quieter retreat. Relax and enjoy Isle Of Palms South with a welcoming hotel that fits your budget perfectly—secure today!

With rooms starting at $134.99, Hampton Inn & Suites Jacksonville Beach Blvd / Mayo Clinic provides budget-friendly comfort for travelers bound for Isle Of Palms South, creating a clean, welcoming environment. Stay on track with your fitness goals using Hampton’s jogging trails or walking paths available at select locations.

With downtown Isle Of Palms South just a short drive away, guests at Hampton Inn & Suites Jacksonville Beach Blvd / Mayo Clinic can explore the city’s top attractions while enjoying a quieter, more peaceful stay. Make your Isle Of Palms South visit memorable with a hotel that delivers more for your money—reserve now!

With budget-friendly rooms from $152.99, Holiday Inn Express & Suites Jacksonville SE Med Center Area an IHG Hotel provides inviting comfort for travelers visiting Isle Of Palms South, creating a warm, welcoming space. Appreciate the seasonal touches at Holiday Inn Express, from summer pool parties to winter hot cocoa stations.

With quick access to downtown Isle Of Palms South, guests at Holiday Inn Express & Suites Jacksonville SE Med Center Area an IHG Hotel can explore the city’s most vibrant spots while staying in a more peaceful location. Enjoy the convenience of a well-located, affordable hotel while visiting Isle Of Palms South—book today!

With rates beginning at $161.99, Hampton Inn Jacksonville / Ponte Vedra Beach Mayo Clinic Area is an ideal choice for budget-savvy travelers to Isle Of Palms South, creating a warm and inviting space. Get a taste of the locale with Hampton’s partnerships with local dining establishments, offering discounts and specials for guests.

With downtown Isle Of Palms South just a short drive away, guests at Hampton Inn Jacksonville / Ponte Vedra Beach Mayo Clinic Area can explore the city’s top attractions while enjoying a quieter, more peaceful stay. Choose a hotel that complements your Isle Of Palms South plans with ease and affordability—secure now!

With budget-conscious rooms starting at $142.49, Holiday Inn Express Jacksonville Beach an IHG Hotel is a practical option for guests bound for Isle Of Palms South, providing a welcoming environment for relaxation. Indulge in the added convenience of Holiday Inn Express's express checkout service, allowing for a swift and easy departure process.

Holiday Inn Express Jacksonville Beach an IHG Hotel offers a convenient location for travelers who want to be near downtown Isle Of Palms South, with the city’s most exciting spots just a quick drive away. Find a hotel that complements your Isle Of Palms South travels with convenience and value—lock in now!

Choose Element Jacksonville Beach for a restful stay near Isle Of Palms South, where inviting rooms offer a peaceful escape, with affordable rates beginning at $169.99 per night. Stay energized with Element by Westin's signature healthy eating options, designed to nourish and delight.

Element Jacksonville Beach offers the perfect location for guests wanting to explore Isle Of Palms South, where the downtown area is just a quick drive away for easy access. Enjoy every moment of your Isle Of Palms South getaway with a hotel that makes you feel welcome—reserve now!

Enjoy the inviting ambiance of Four Points by Sheraton Jacksonville Beachfront near Isle Of Palms South, where restful rooms create a peaceful atmosphere, with affordable nightly rates starting from $219.99. Enjoy the excitement of Sheraton’s themed event nights, from local music and dance to international celebrations.

With downtown Isle Of Palms South only a short drive away, guests at Four Points by Sheraton Jacksonville Beachfront can explore the city’s top attractions while enjoying a quieter stay. Find the perfect Isle Of Palms South escape with a hotel that combines elegance and affordability—lock in today!

Enjoy a relaxing environment at Best Western Oceanfront near Isle Of Palms South, with inviting rooms designed for comfort and value, all beginning at an affordable $130.99 per night. Opt for Best Western Plus® Executive Residency for longer stays, offering apartment-like amenities with the convenience of hotel services.

With downtown Isle Of Palms South only a short drive away, guests at Best Western Oceanfront can explore the city’s best attractions without staying in the busiest parts. Relax and enjoy every aspect of your Isle Of Palms South visit with a hotel that caters to you—secure now!

Embrace luxurious surroundings at Springhill Suites by Marriott Jacksonville Beach Oceanfront as you visit Isle Of Palms South, where refined accommodations provide a welcoming retreat, with rates starting from $189.99. Stay with peace of mind, thanks to the enhanced cleaning protocols firmly in place at SpringHill Suites.

With downtown Isle Of Palms South only a quick drive away, guests at Springhill Suites by Marriott Jacksonville Beach Oceanfront can enjoy easy access to the city’s most vibrant attractions while staying in a more peaceful location. Step into elegance in Isle Of Palms South with a hotel that promises an unforgettable stay—book today!

Choose Casa Marina Hotel for a comfortable escape near Isle Of Palms South, where welcoming rooms create a welcoming retreat, with affordable rates beginning at $136.99. Stay in accommodations that focus on providing an exceptional level of comfort, with modern amenities to enhance your visit.

With downtown Isle Of Palms South just a short distance by car, guests at Casa Marina Hotel can explore the city’s top sights while enjoying a quieter, more peaceful stay. Experience Isle Of Palms South worry-free with a hotel that goes above and beyond to please—reserve your room now!

At Margaritaville Jacksonville Beach, travelers to Isle Of Palms South can unwind in relaxed comfort with rooms beginning at $169.99, creating a warm and inviting space ideal for relaxation. Stay in accommodations that offer more than the essentials, with added features to make your visit both pleasant and affordable.

At Margaritaville Jacksonville Beach, a brief drive takes guests into downtown Isle Of Palms South, where the city’s top destinations are easily accessible. Relax in Isle Of Palms South with lodging that offers comfort and cost savings—reserve your room today!

At Hampton Inn Jacksonville Beach / Oceanfront, visitors to Isle Of Palms South will find comfortable accommodations that blend quality and value, with cushy rooms available from a welcoming $171.99 per night. Experience the local culture with Hampton's carefully curated local guides, offering insider tips on the best dining, shopping, and attractions.

Hampton Inn Jacksonville Beach / Oceanfront provides easy access to downtown Isle Of Palms South, offering guests the flexibility to visit the city’s top sights with just a short drive. Relax and recharge in Isle Of Palms South with accommodations that provide exceptional value—book today!

At Fairfield Inn & Suites by Marriott Jacksonville Beach, travelers to Isle Of Palms South will find inviting rooms with rates from $174.99, creating a warm, welcoming space perfect for relaxation. Discover Fairfield's convenient locations, ideally situated near highways, airports, and popular attractions for easy travel.

At Fairfield Inn & Suites by Marriott Jacksonville Beach, a quick drive delivers guests into the vibrant downtown area of Isle Of Palms South, where the city’s most iconic destinations are within reach. Enjoy an effortless Isle Of Palms South adventure with budget-conscious, inviting lodging—book now!

Experience the inviting ambiance of Courtyard by Marriott Jacksonville Beach Oceanfront on your visit to Isle Of Palms South, where tranquil accommodations create a warm stay, with rates starting at $152.99. Stay entertained with Courtyard's game rooms, providing fun and interactive activities for guests of all ages.

Guests staying at Courtyard by Marriott Jacksonville Beach Oceanfront will love the convenience of being close to downtown Isle Of Palms South, where the city’s most popular destinations are always nearby. Take your Isle Of Palms South adventure to new heights with a hotel that provides exceptional service—secure now!

Immerse yourself in sheer elegance at The Lodge&Club at Ponte Vedra Beach as you journey to Isle Of Palms South, where opulent accommodations await, with inviting rates from $599.99. Relax in rooms that are designed to be sanctuaries of luxury, offering bespoke furnishings, ambient lighting, and a soothing atmosphere.

At The Lodge&Club at Ponte Vedra Beach, guests are never far from downtown Isle Of Palms South, making it simple to explore the city’s top destinations with just a short drive. Discover the grace of Isle Of Palms South with accommodations that deliver a flawless journey—reserve now!

With budget-friendly rooms starting at $137.99, Salt Air Inn & Suites is ideal for travelers bound for Isle Of Palms South, providing a warm and inviting environment for relaxation. Stay in rooms that offer a step up in amenities and comfort, providing a more enjoyable and budget-friendly visit.

Guests staying at Salt Air Inn & Suites are never far from downtown Isle Of Palms South, where a short drive brings them to the city’s most exciting destinations. Take advantage of thoughtful amenities and affordable rates for your Isle Of Palms South trip—book today!

With a touch of extravagance, One Ocean Resort&Spa near Isle Of Palms South promises a stay of supreme elegance, where inviting accommodations await, with rates from just $179.00. Enjoy accommodations where luxury is a standard, featuring rooms that blend artistic design with exceptional comfort.

At One Ocean Resort&Spa, guests can enjoy the convenience of a short drive into downtown Isle Of Palms South, making it easy to explore the city’s most vibrant spots. Unwind in Isle Of Palms South with accommodations that turn luxury into a way of life—secure now!

With affordable rooms from $151.20, Seahorse Oceanfront Inn provides budget-friendly accommodations for guests bound for Isle Of Palms South, creating a delightful and welcoming space. Find a balance of comfort and value in rooms that provide a straightforward, clean, and comfortable environment.

With downtown Isle Of Palms South just a short drive away, guests at Seahorse Oceanfront Inn can explore the city’s top attractions while enjoying a quieter, more peaceful stay. Make Isle Of Palms South travel effortless and affordable with inviting accommodations—secure today!

Relax at Marble Waters Hotel & Suites Trademark by Wyndham as you explore Isle Of Palms South, where comfortable rooms provide a restful stay, with inviting rates beginning at just $100.99 per night. Relax in accommodations that cater to your comfort and convenience, with rooms equipped with all the modern amenities.

With downtown Isle Of Palms South only a short drive away, guests at Marble Waters Hotel & Suites Trademark by Wyndham can explore the city’s top attractions while enjoying a quieter setting. Enjoy a Isle Of Palms South hotel that offers more than just a stay—it’s an experience to remember—book today!

Find the perfect balance of comfort and value at Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass as you explore Isle Of Palms South, where inviting accommodations begin at an accessible $144.99 per night. Bring your pets along to Hilton Garden Inn, where pet-friendly rooms and special amenities ensure a comfortable stay for all your family members.

Guests staying at Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass can enjoy the calm of being slightly removed from the city’s busiest areas, with downtown Isle Of Palms South just a drive away. Experience Isle Of Palms South with a hotel that goes the extra mile to make your visit memorable—secure now!

For budget-conscious travelers visiting Isle Of Palms South, Holiday Inn Express & Suites Jacksonville Mayport / Beach an IHG Hotel offers inviting accommodations with rates beginning at $139.00, creating a clean and comfortable space. Savor the convenience of Holiday Inn Express's grab-and-go breakfast options, perfect for early risers or guests on the move.

Staying at Holiday Inn Express & Suites Jacksonville Mayport / Beach an IHG Hotel allows guests to enjoy a more tranquil setting, while still being close enough to downtown Isle Of Palms South for a day of exploration. Experience Isle Of Palms South in comfort and style without overspending—lock in your room now!

For those headed to Isle Of Palms South, Holiday Inn Express & Suites Jacksonville Town Center an IHG Hotel offers budget-friendly accommodations with rooms from $179.00, creating a clean, comfortable environment perfect for rest. Relax in the modern simplicity of Holiday Inn Express's guest rooms, designed for both comfort and functionality.

At Holiday Inn Express & Suites Jacksonville Town Center an IHG Hotel, visitors can take a short drive into downtown Isle Of Palms South, where they can experience the city’s highlights and return to a more serene stay. Relax in Isle Of Palms South with a hotel that blends comfort and savings perfectly—reserve now!

Step into an ambiance of class at Sawgrass Marriott Golf Resort & Spa near Isle Of Palms South, where inviting rooms blend style with relaxation, with enticing rates starting from $239.99. Experience the convenience of high-speed internet and modern workspaces in Marriott's guest rooms, catering to the needs of business travelers.

Guests at Sawgrass Marriott Golf Resort & Spa can easily access downtown Isle Of Palms South, while appreciating the hotel’s more relaxed and spacious accommodations. Discover how Isle Of Palms South becomes unforgettable with a hotel that caters to your every wish—secure now!