The best deals on hotels when visiting Cairo in Missouri.

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Top 24 Hotels In Cairo, Missouri 65239

Comfort Inn & Suites Moberly

1801 West Outer Rd Moberly, MO

With rooms beginning at $103.99, Comfort Inn & Suites Moberly is a practical option for travelers to Cairo, providing budget-conscious accommodations in a homely setting. Make the most of Comfort Inn's recreational facilities, including pools and fitness centers, for a balanced and enjoyable stay.

From Comfort Inn & Suites Moberly, a brief drive delivers guests into downtown Cairo, making it simple to explore the city’s top spots. Step into an unforgettable Cairo adventure with lodging that offers more for less—lock in today!

  Call (855) 235-0725 to book with an agent.
  4.8 miles from Cairo, MO 65239

Starting at

$103.99

per night

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Super 8 by Wyndham Moberly MO

300 East Highway 24 Moberly, MO

With budget-friendly rooms beginning at $78.99, Super 8 by Wyndham Moberly MO provides affordable accommodations for travelers bound for Cairo, creating a comforting and welcoming environment. Discover the ease of travel with Super 8's prime locations, conveniently close to major roads and local attractions.

Guests staying at Super 8 by Wyndham Moberly MO are never far from the heart of Cairo, where a quick drive brings them to the city’s best attractions. Book now for a convenient, wallet-friendly Cairo experience—secure today!

  Call (855) 235-0725 to book with an agent.
  4.9 miles from Cairo, MO 65239

Starting at

$78.99

per night

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Americas Best Value Inn & Suites Macon at Sunset Dr

28933 Sunset Drive Macon, MO

Guests bound for Cairo will appreciate the quiet comfort at Americas Best Value Inn & Suites Macon at Sunset Dr, where budget-friendly rooms start at $76.99, creating a warm and welcoming atmosphere. Wake up to freshly brewed coffee available in your room, providing a delightful start to your day.

Travelers staying at Americas Best Value Inn & Suites Macon at Sunset Dr can unwind in serene surroundings, while downtown Cairo remains close enough for city adventures. Make your Cairo experience enjoyable without the high cost—reserve today!

  Call (855) 233-7850 to book with an agent.
  16.6 miles from Cairo, MO 65239

Starting at

$76.99

per night

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Travelier Motel

201 East Briggs Dr Macon, MO

At Travelier Motel, guests traveling to Cairo will find quiet, budget-friendly rooms starting at $70.00, creating a clean and welcoming environment for relaxation. Find value and simplicity in rooms that provide the necessary comforts for a restful night's sleep and a pleasant stay.

Relax at Travelier Motel, where peaceful surroundings create a restful stay, while downtown Cairo remains a quick drive away for sightseeing. Make Cairo travel effortless and affordable with inviting accommodations—secure today!

  Call (855) 234-2997 to book with an agent.
  16.7 miles from Cairo, MO 65239

Starting at

$70.00

per night

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Super 8 by Wyndham Macon

203 East Briggs Dr Macon, MO

Guests visiting Cairo can relax at Super 8 by Wyndham Macon, where affordable rooms begin at $86.99, creating a warm and welcoming environment ideal for relaxation. Discover Super 8's Wyndham Rewards program, offering guests points towards free nights, gift cards, and more with every stay.

For a calm escape, Super 8 by Wyndham Macon offers a quiet retreat while keeping downtown Cairo within reach for sightseeing and adventure. Stay affordably and comfortably on your Cairo adventure—lock in your hotel today!

  Call (855) 234-7135 to book with an agent.
  16.7 miles from Cairo, MO 65239

Starting at

$86.99

per night

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Simple Rewards Inn Shelbina

711 North Highway 15 Shelbina, MO

For a peaceful stay near Cairo, Simple Rewards Inn Shelbina offers inviting accommodations with rooms starting at $91.99, creating a welcoming space perfect for relaxation. Find simplicity and satisfaction in rooms that offer clean, functional amenities for a fuss-free stay.

Enjoy a quiet stay at Simple Rewards Inn Shelbina, where guests can recharge and still visit Cairo's lively attractions just a short drive away. Make your Cairo experience enjoyable and budget-friendly—lock in now!

  Call (855) 235-6136 to book with an agent.
  25.2 miles from Cairo, MO 65239

Starting at

$91.99

per night

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Hotel Marceline

101 West Ira Street Marceline, MO

For an inviting and affordable stay, Hotel Marceline offers budget-friendly rooms with rates starting at $84.99, creating a clean and comfortable space. Enjoy upgraded accommodations that provide additional comfort and amenities, all designed to enhance your travel experience.

Settle into comfort at Hotel Marceline, where guests can recharge in a serene setting with the energy of Cairo a short drive away. Enjoy Cairo adventures with a hotel that’s all about comfort and savings—lock in today!

  Call (855) 234-2997 to book with an agent.
  30.6 miles from Cairo, MO 65239

Starting at

$84.99

per night

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Midway Budget Inn

6401 US 40 Columbia, MO

Guests headed to Cairo will find budget-friendly comfort at Midway Budget Inn, where easygoing rooms begin at $79.95, creating a welcoming atmosphere perfect for relaxation. Relax in accommodations that offer more than just the essentials, providing a comfortable and enjoyable experience at a budget-friendly price.

Stay at Midway Budget Inn for a peaceful escape, with the bonus of being close to Cairo's lively streets for daily adventures. Experience Cairo without overspending with a hotel that enhances your visit—lock in now!

  Call (855) 236-8982 to book with an agent.
  37.1 miles from Cairo, MO 65239

Starting at

$79.95

per night

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Extended Stay America Select Suites Columbia Stadium Blvd.

W Business Loop 70 Columbia, MO

Guests bound for Cairo will appreciate the warm comfort at Extended Stay America Select Suites Columbia Stadium Blvd., with budget-friendly rooms beginning at $87.99, creating a warm and inviting space. Enjoy the accessibility of Extended Stay America’s locations, conveniently situated near business districts, shopping, and dining.

Discover a quiet haven at Extended Stay America Select Suites Columbia Stadium Blvd., where calm accommodations offer the perfect balance with proximity to Cairo. Settle into Cairo with a hotel that prioritizes your relaxation and budget—secure now!

  Call (855) 233-0132 to book with an agent.
  37.6 miles from Cairo, MO 65239

Starting at

$87.99

per night

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Baymont by Wyndham Columbia MO

2500 I 70 Dr. Sw Columbia, MO

With rates beginning at $62.99, Baymont by Wyndham Columbia MO is ideal for guests visiting Cairo, offering charming accommodations in a welcoming, clean environment. Enjoy the extra space and privacy of Baymont by Wyndham’s suites, which feature separate living areas and additional amenities.

Recharge in the comfort of Baymont by Wyndham Columbia MO, where restful surroundings are matched by the proximity to Cairo's attractions. Get ready to enjoy Cairo with accommodations that balance cost and comfort—lock in today!

  Call (855) 234-2997 to book with an agent.
  37.6 miles from Cairo, MO 65239

Starting at

$62.99

per night

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Holiday Inn Executive Center Columbia Mall an IHG Hotel

2200 I 70 Dr. SW Columbia, MO

Enjoy the elevated comfort of Holiday Inn Executive Center Columbia Mall an IHG Hotel near Cairo, where inviting accommodations provide quality, with nightly rates beginning at just $107.20. Use Holiday Inn’s shuttle services for hassle-free transportation to local attractions, airports, and more.

Unwind at Holiday Inn Executive Center Columbia Mall an IHG Hotel, a quiet haven where guests can recharge while keeping Cairo close enough for exploration. Relax in Cairo with a hotel that takes care of every detail, so you don’t have to—lock in today!

  Call (855) 234-5074 to book with an agent.
  37.7 miles from Cairo, MO 65239

Starting at

$107.20

per night

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Red Roof Inn Columbia MO

201 East Texas Ave Columbia, MO

At Red Roof Inn Columbia MO, travelers bound for Cairo will find delightful rooms starting at $64.00, creating a welcoming, comfortable environment perfect for a peaceful stay. Rest with ease at Red Roof Inn, knowing the dedicated staff are always available to address your needs and ensure a pleasant stay.

Enjoy a peaceful stay at Red Roof Inn Columbia MO, where guests can relax and still visit Cairo's lively streets whenever they choose. Stay comfortably on your Cairo adventure with budget-friendly rates—book now!

  Call (855) 235-0725 to book with an agent.
  37.8 miles from Cairo, MO 65239

Starting at

$64.00

per night

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Comfort Suites Columbia University Area

1010 Business Loop 70 W Columbia, MO

With rates from $77.99, Comfort Suites Columbia University Area is ideal for travelers bound for Cairo, providing relaxed, budget-friendly accommodations perfect for relaxation. Relax in Comfort Suites' therapeutic shower systems, available in select suites for a spa-like shower experience.

Step away from the hustle and bustle at Comfort Suites Columbia University Area, where restful lodgings are paired with the convenience of being close to Cairo. Choose accommodations that make Cairo travel feel effortless—lock in your stay now!

  Call (855) 236-8982 to book with an agent.
  37.9 miles from Cairo, MO 65239

Starting at

$77.99

per night

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Hilton Garden Inn Columbia

3300 Vandiver Dr Columbia, MO

Enjoy the peaceful surroundings of Hilton Garden Inn Columbia on your journey to Cairo, where comfortable accommodations provide relaxation, with nightly rates starting at $114.99. Relax in the spacious accommodations of Hilton Garden Inn's suites, which offer separate living areas and upgraded amenities.

Discover the comfort of Hilton Garden Inn Columbia, where spacious rooms provide a calm atmosphere with Cairo never far away. Embrace a Cairo visit where luxury meets affordability—lock in your hotel room today!

  Call (855) 239-4019 to book with an agent.
  37.9 miles from Cairo, MO 65239

Starting at

$114.99

per night

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Best Western Brookfield

28622 Highway 11 Brookfield, MO

For a comfortable stay near Cairo, Best Western Brookfield offers budget-conscious rooms with rates beginning at $138.99, creating a inviting, inviting space for relaxation. Relax in the modern style and comfort of Best Western’s guest rooms, equipped with all the amenities needed for a pleasant stay.

Enjoy the calm atmosphere of Best Western Brookfield, where a relaxing stay is paired with convenient access to Cairo. Enjoy Cairo from a hotel that enhances your travel experience—lock in now!

  Call (855) 239-5277 to book with an agent.
  38.1 miles from Cairo, MO 65239

Starting at

$138.99

per night

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Candlewood Suites Columbia East an IHG Hotel

1400 Creekwood Parkway Columbia, MO

With budget-friendly rooms beginning at $124.00, Candlewood Suites Columbia East an IHG Hotel provides inviting accommodations for travelers visiting Cairo, creating a friendly, welcoming environment. The modern and efficient design of Candlewood Suites' accommodations combines style with functionality for a seamless stay.

Escape the crowds at Candlewood Suites Columbia East an IHG Hotel, where you can enjoy quiet comfort while keeping Cairo's attractions within easy reach. Rest easy in Cairo with a hotel that balances affordability and comfort—reserve today!

  Call (855) 234-5074 to book with an agent.
  38.6 miles from Cairo, MO 65239

Starting at

$124.00

per night

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Best Western Teal Lake Inn

3602 South Clark St Mexico, MO

At Best Western Teal Lake Inn, guests bound for Cairo can enjoy budget-friendly accommodations with rooms starting at $88.99, creating a welcoming and comfortable space. Enjoy the quiet policy at Best Western hotels, ensuring noise is kept to a minimum for a peaceful stay.

Unwind in the calm environment of Best Western Teal Lake Inn, where city attractions are just a quick drive away for your convenience. Relax and recharge in Cairo with a hotel that keeps your wallet happy—book today!

  Call (855) 234-2997 to book with an agent.
  38.6 miles from Cairo, MO 65239

Starting at

$88.99

per night

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SpringHill Suites by Marriott Columbia

3415 Clark Lane Columbia, MO

Unwind at SpringHill Suites by Marriott Columbia on your trip to Cairo, where inviting accommodations create a peaceful retreat, with budget-friendly rates from $114.99. In-room entertainment at SpringHill Suites includes flat-screen TVs and streaming services for a relaxing evening.

For a peaceful retreat close to Cairo, SpringHill Suites by Marriott Columbia provides a quiet escape with convenient access to urban adventures. Plan your Cairo adventure with a hotel that combines modern flair with traditional comfort—reserve now!

  Call (855) 239-5277 to book with an agent.
  38.6 miles from Cairo, MO 65239

Starting at

$114.99

per night

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Best Western Plus Columbia Inn

2904 Clark Lane Columbia, MO

With rooms starting at $67.99, Best Western Plus Columbia Inn provides inviting accommodations for guests traveling to Cairo, creating a intimate-feeling, welcoming environment. Relax with a drink at the on-site bar at Best Western Plus, where you can enjoy a selection of cocktails, wines, and beers.

Relax in comfort at Best Western Plus Columbia Inn, where serene surroundings and easy access to Cairo make for a perfect getaway. Experience the charm of Cairo with a hotel that goes above and beyond—book today!

  Call (855) 233-0132 to book with an agent.
  38.6 miles from Cairo, MO 65239

Starting at

$67.99

per night

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Super 8 by Wyndham Columbia Clark Lane

3216 Clark Ln Columbia, MO

At Super 8 by Wyndham Columbia Clark Lane, guests visiting Cairo can enjoy affordable comfort with rooms starting at $53.99, providing a welcoming and comfortable environment. Enter the world of Super 8 by Wyndham, where you can expect reliable comfort and excellent service at a competitive price.

Discover comfort at Super 8 by Wyndham Columbia Clark Lane, offering a peaceful stay with easy access to all the exciting activities in Cairo. Plan your Cairo visit with ease and value-driven comfort—secure your stay today!

  Call (855) 234-5074 to book with an agent.
  38.6 miles from Cairo, MO 65239

Starting at

$53.99

per night

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Hampton Inn Columbia

3410 Clark Lane Columbia, MO

Guests headed to Cairo can unwind in affordable comfort at Hampton Inn Columbia, where safe rooms start at $105.99, creating a clean, welcoming atmosphere. Discover the ease of Hampton’s park-and-stay packages, offering convenient parking options for travelers on the road.

Unwind in the tranquil setting of Hampton Inn Columbia, a perfect spot to relax while keeping Cairo close enough for adventure. Plan a relaxing Cairo getaway with accommodations that keep costs in check—book today!

  Call (855) 235-6136 to book with an agent.
  38.7 miles from Cairo, MO 65239

Starting at

$105.99

per night

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Fairfield Inn & Suites by Marriott Columbia

1115 Woodland Springs Ct Columbia, MO

With rooms beginning at $98.99, Fairfield Inn & Suites by Marriott Columbia provides inviting accommodations for guests traveling to Cairo, creating a welcoming and comfortable atmosphere. Stay satisfied with Fairfield’s snack and beverage stations, conveniently placed in the lobby for quick access.

Find your perfect retreat at Fairfield Inn & Suites by Marriott Columbia, where the quiet atmosphere lets you unwind while Cairo remains just a drive away. Take your Cairo stay to the next level with affordable, well-equipped lodging—reserve now!

  Call (855) 233-7850 to book with an agent.
  38.7 miles from Cairo, MO 65239

Starting at

$98.99

per night

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Days Inn by Wyndham Mexico

2902 South Clark Mexico, MO

With affordable rooms starting at $89.99, Days Inn by Wyndham Mexico provides budget-friendly comfort for travelers to Cairo, creating a welcoming environment for rest and ease. Choose Days Inn for a seamless travel experience, where every aspect of your stay is handled with care and precision.

At Days Inn by Wyndham Mexico, guests can recharge in a quiet setting while keeping Cairo's excitement within reach for daily adventures. Enjoy Cairo with a hotel that keeps you comfortable without the extra cost—reserve today!

  Call (855) 236-8982 to book with an agent.
  38.8 miles from Cairo, MO 65239

Starting at

$89.99

per night

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Residence Inn by Marriott Columbia

1100 Woodland Springs Ct Columbia, MO

At Residence Inn by Marriott Columbia, enjoy the comfort of quality accommodations when visiting Cairo, with inviting rooms that start from a budget-friendly $134.99. Experience community-driven hospitality at Residence Inn, where guest satisfaction and personalized service are prioritized.

Escape to the comfort of Residence Inn by Marriott Columbia, a tranquil spot where guests can relax and still explore Cairo with ease. Relax and enjoy Cairo with a hotel that keeps your comfort in mind—book your room today!

  Call (855) 236-8982 to book with an agent.
  38.8 miles from Cairo, MO 65239

Starting at

$134.99

per night

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