The best deals on hotels when visiting Irene in South Dakota.

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Top 24 Hotels In Irene, South Dakota 57073

Best Western Kelly Inn

1607 East Highway 50 Yankton, SD

At Best Western Kelly Inn, travelers to Irene will find inviting rooms with rates beginning at $126.99, creating a warm, comfortable space ideal for relaxation. Trust in Best Western's pet-friendly policies at many locations, ensuring your furry friends can join in on your travels.

Guests at Best Western Kelly Inn will enjoy the calm atmosphere, while the convenience of downtown Irene remains just a short drive away. Take advantage of Irene travel with a hotel that adds convenience to your journey—reserve today!

  Call (855) 234-2997 to book with an agent.
  17.6 miles from Irene, SD 57073

Starting at

$126.99

per night

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Econo Lodge Inn & Suites

2410 Broadway Ave Yankton, SD

Guests bound for Irene will appreciate the calm accommodations at Econo Lodge Inn & Suites, with rooms starting at $92.99, providing a warm, welcoming space for rest. Stay refreshed and ready to go with Econo Lodge's complimentary coffee, providing a quick energy boost any time of day.

For a relaxing getaway, Econo Lodge Inn & Suites provides calm surroundings while keeping downtown Irene within easy reach for exploration. Enjoy Irene with a hotel that keeps your comfort and budget in mind—reserve today!

  Call (855) 239-5277 to book with an agent.
  17.7 miles from Irene, SD 57073

Starting at

$92.99

per night

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Yankton Inn

1603 East Highway 50 Yankton, SD

With rooms starting at $95.99, Yankton Inn offers inviting accommodations for travelers to Irene, creating a warm-hearted and welcoming environment ideal for rest. Find straightforward accommodations that prioritize essential comforts and value, making your stay efficient and enjoyable.

Guests at Yankton Inn will appreciate the quiet atmosphere, while a smooth drive delivers them to the sights and attractions of downtown Irene. Enjoy Irene to the fullest with a welcoming, cost-effective hotel—reserve now!

  Call (855) 234-7135 to book with an agent.
  17.7 miles from Irene, SD 57073

Starting at

$95.99

per night

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Comfort Inn Yankton SD

611 West 23rd Street Yankton, SD

For a relaxing and budget-conscious stay near Irene, Comfort Inn Yankton SD offers inviting accommodations with rooms starting at $179.99, creating a warm space for rest. Trust Comfort Inn for a hassle-free stay, with efficient service and comfortable accommodations at every turn.

For those seeking a blend of relaxation and city exploration, Comfort Inn Yankton SD offers tranquility with downtown Irene a drive away. Enjoy the convenience of a well-appointed hotel in Irene without the high price—secure now!

  Call (855) 234-2997 to book with an agent.
  18.0 miles from Irene, SD 57073

Starting at

$179.99

per night

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Fairfield Inn & Suites by Marriott Yankton

508 WEST 21ST STREET Yankton, SD

With rooms beginning at $189.99, Fairfield Inn & Suites by Marriott Yankton provides inviting accommodations for guests traveling to Irene, creating a welcoming and comfortable atmosphere. Experience the freedom of seamless travel with Fairfield's efficient check-in and check-out processes, designed to save you time.

Guests seeking relaxation can find solace at Fairfield Inn & Suites by Marriott Yankton, with downtown Irene still nearby for a balanced stay of exploration and rest. Plan your Irene adventure with ease, knowing your accommodations are perfect—book today!

  Call (855) 236-8982 to book with an agent.
  18.0 miles from Irene, SD 57073

Starting at

$189.99

per night

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Super 8 by Wyndham Beresford

1410 West Cedar St Beresford, SD

With rates starting at $94.99, Super 8 by Wyndham Beresford is a practical choice for travelers visiting Irene, providing a warm and inviting atmosphere for rest. Choose Super 8 by Wyndham for your next adventure, where friendly service and comfortable stays come at an unbeatable value.

Unwind in the calm atmosphere of Super 8 by Wyndham Beresford, where quiet surroundings create a relaxing stay, and downtown Irene is still nearby. Enjoy a practical, budget-conscious stay with perks in Irene—book now!

  Call (855) 239-4019 to book with an agent.
  18.5 miles from Irene, SD 57073

Starting at

$94.99

per night

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Best Western Vermillion Inn

701 West Cherry St Vermillion, SD

At Best Western Vermillion Inn, guests traveling to Irene can unwind in affordable comfort with rooms starting at $297.72, creating a heartwarming and welcoming space ideal for relaxation. Relax in the unique charm of Best Western's eco-friendly rooms, featuring sustainable practices and natural decor.

Found just beyond the busy city center, Best Western Vermillion Inn provides a calm setting while keeping Irene's top spots within easy reach. Unwind in Irene with budget-friendly accommodations that don’t skimp on comfort—book now!

  Call (855) 239-4019 to book with an agent.
  23.2 miles from Irene, SD 57073

Starting at

$297.72

per night

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Lewis&Clark Resort

43496 Shore Drive Yankton, SD

Guests visiting Irene can unwind in restorative accommodations at Lewis&Clark Resort, where rooms start at $113.85, creating a warm and inviting atmosphere. Relax in rooms that combine comfort with affordability, offering extra amenities to enhance your travel experience.

Discover relaxation at Lewis&Clark Resort, where quiet comfort meets the convenience of being close to Irene's vibrant offerings. Treat yourself to an affordable, inviting hotel experience in Irene—book today!

  Call (855) 233-7850 to book with an agent.
  23.7 miles from Irene, SD 57073

Starting at

$113.85

per night

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Gateway Park Hotel&Suites

830 Gateway Lane Tea, SD

With affordable rooms beginning at $156.99, Gateway Park Hotel&Suites provides inviting accommodations for guests visiting Irene, creating a warm, comfortable space. Experience added convenience and comfort in rooms that provide extra amenities, making your stay both pleasant and affordable.

Unwind at Gateway Park Hotel&Suites, a restful retreat situated just a short drive from the vibrant offerings of Irene. Make your Irene visit memorable and stress-free with inviting amenities—lock in today!

  Call (855) 234-5074 to book with an agent.
  30.9 miles from Irene, SD 57073

Starting at

$156.99

per night

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Cobblestone Inn & Suites Hartington

405 Arens Dr Hartington, NE

For a budget-friendly and inviting stay near Irene, Cobblestone Inn & Suites Hartington offers harmonious accommodations with rates beginning at $162.99, creating a warm and comfortable environment. Experience a more enjoyable visit with enhanced amenities in rooms designed for comfort and affordability.

For a peaceful stay with a short drive to the action, Cobblestone Inn & Suites Hartington provides the perfect escape just outside Irene. Stay refreshed and on budget in Irene with thoughtfully designed accommodations—secure today!

  Call (855) 239-4019 to book with an agent.
  32.7 miles from Irene, SD 57073

Starting at

$162.99

per night

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Towneplace Suites Sioux Falls South

6400 South Connie Avenue Sioux Falls, SD

For a restful stay near Irene, Towneplace Suites Sioux Falls South offers alluring accommodations with rooms from $209.99, creating a clean and comfortable environment perfect for relaxation. Start your day with TownePlace Suites' complimentary hot breakfast, featuring a variety of choices to fuel your adventures.

Escape the city bustle at Towneplace Suites Sioux Falls South, where a relaxing atmosphere awaits and Irene remains within a short drive. Treat yourself to a well-appointed, affordable hotel while exploring Irene—reserve today!

  Call (855) 233-7850 to book with an agent.
  33.9 miles from Irene, SD 57073

Starting at

$209.99

per night

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Hilton Garden Inn Sioux Falls South

5300 South Grand Cir Sioux Falls, SD

Stay affordably at Hilton Garden Inn Sioux Falls South on your visit to Irene, where comfortable rooms create a restful retreat, with room rates starting at just $192.99. Enjoy gathering in Hilton Garden Inn's communal dining areas, which offer a welcoming space for sharing meals and stories with other guests.

At Hilton Garden Inn Sioux Falls South, guests can settle into spacious comfort and still reach Irene with ease for day trips and exploration. Experience the best of Irene with accommodations that add value to your adventure—reserve now!

  Call (855) 234-7135 to book with an agent.
  34.2 miles from Irene, SD 57073

Starting at

$192.99

per night

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Holiday Inn Express&Suites Sioux Falls SW an IHG Hotel

3821 West Avera Dr Sioux Falls, SD

With rates from $186.98, Holiday Inn Express&Suites Sioux Falls SW an IHG Hotel is a convenient option for travelers visiting Irene, providing inviting accommodations in a welcoming environment. Relax in Holiday Inn Express's indoor heated pool, a perfect year-round relaxation spot for guests of all ages.

Recharge in the comfort of Holiday Inn Express&Suites Sioux Falls SW an IHG Hotel, where guests can unwind in peace while keeping Irene within reach for exploration. Get more out of your Irene adventure with accommodations that save you money—secure now!

  Call (855) 234-5074 to book with an agent.
  34.2 miles from Irene, SD 57073

Starting at

$186.98

per night

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Comfort Inn & Suites Avera Southwest

3721 West Avera Drive Sioux Falls, SD

Guests visiting Irene can unwind in pleasant accommodations at Comfort Inn & Suites Avera Southwest, where rooms start at $229.75, creating a warm and inviting atmosphere. Keep up with your fitness routine in Comfort Inn's well-equipped fitness centers, maintaining your health and wellness while traveling.

Step into comfort at Comfort Inn & Suites Avera Southwest, where guests can relax and still reach the cultural and entertainment hotspots of Irene. Enjoy Irene without compromise with a hotel that delivers exceptional value—reserve now!

  Call (855) 235-0725 to book with an agent.
  34.2 miles from Irene, SD 57073

Starting at

$229.75

per night

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Homewood Suites by Hilton Sioux Falls

3620 West Avera Dr Sioux Falls, SD

Choose Homewood Suites by Hilton Sioux Falls for a comfortable stay near Irene, where inviting rooms create a relaxing environment, with room rates starting at $137.99 per night. Enjoy the vibrant community events at Homewood Suites, including local artist showcases and cultural celebrations.

Take a break from the city buzz at Homewood Suites by Hilton Sioux Falls, a peaceful spot where Irene is always close enough for a quick trip. Enjoy every moment of your Irene adventure with a hotel that prioritizes quality and affordability—lock in today!

  Call (855) 233-7850 to book with an agent.
  34.3 miles from Irene, SD 57073

Starting at

$137.99

per night

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Hawarden Harvest Inn

70 Ave. E Hawarden, IA

With rooms beginning at $92.99, Hawarden Harvest Inn provides budget-friendly accommodations for travelers visiting Irene, creating a warm and welcoming environment. Experience added convenience and comfort in rooms that provide extra amenities, making your stay both pleasant and affordable.

Escape the crowds at Hawarden Harvest Inn, where guests can relax in quiet comfort with Irene's highlights just a short drive away. Choose a well-rounded, budget-friendly stay for your Irene adventure—book now!

  Call (855) 234-5074 to book with an agent.
  34.4 miles from Irene, SD 57073

Starting at

$92.99

per night

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Residence Inn Sioux Falls

4509 West Empire Pl Sioux Falls, SD

Find relaxation and value at Residence Inn Sioux Falls as you journey to Irene, where quality rooms provide a gentle atmosphere, with inviting rates beginning at $214.99. Utilize the versatile meeting spaces at Residence Inn for your next business event or personal gathering.

Enjoy a relaxing stay at Residence Inn Sioux Falls, where a quiet environment allows you to unwind with the option to visit Irene at your leisure. Discover how relaxing Irene can be with a hotel that ensures your happiness—secure now!

  Call (855) 234-7135 to book with an agent.
  34.9 miles from Irene, SD 57073

Starting at

$214.99

per night

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Fairfield Inn & Suites Sioux Falls

4501 West Empire Place Sioux Falls, SD

With budget-friendly rooms from $202.99, Fairfield Inn & Suites Sioux Falls is an ideal choice for guests traveling to Irene, creating a clean and inviting space for unwinding. Experience the festive spirit of Fairfield during the holidays, with special decorations, events, and treats to celebrate the season.

Escape to the comfort of Fairfield Inn & Suites Sioux Falls, a tranquil spot where guests can relax and still explore Irene with ease. Make the most of your Irene experience with a hotel that keeps you comfortable—secure now!

  Call (855) 236-8982 to book with an agent.
  35.0 miles from Irene, SD 57073

Starting at

$202.99

per night

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AmericInn by Wyndham Sioux Falls

3508 South Gateway Blvd Sioux Falls, SD

With rates beginning at $110.99, AmericInn by Wyndham Sioux Falls provides budget-friendly comfort for travelers bound for Irene, creating a clean, inviting space. Take a break in AmericInn by Wyndham’s outdoor spaces, where you can enjoy fresh air and relaxation.

Escape to AmericInn by Wyndham Sioux Falls for a refreshing stay, where peaceful surroundings are paired with the convenience of Irene's top spots. Make your Irene experience stress-free with a hotel that offers unbeatable value—book today!

  Call (855) 234-5074 to book with an agent.
  35.1 miles from Irene, SD 57073

Starting at

$110.99

per night

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Days Inn by Wyndham Sioux Falls Empire

3401 Gateway Blvd Sioux Falls, SD

At Days Inn by Wyndham Sioux Falls Empire, guests bound for Irene will find affordable accommodations with rates starting at $82.99, creating a clean and welcoming environment perfect for rest. Appreciate Days Inn's commitment to sustainability, with eco-friendly initiatives and practices in place at select locations.

Stay at Days Inn by Wyndham Sioux Falls Empire for a restful experience, where the peaceful ambiance is complemented by the proximity to Irene's highlights. Stay budget-wise while enjoying Irene in comfort—secure your hotel today!

  Call (855) 234-7135 to book with an agent.
  35.2 miles from Irene, SD 57073

Starting at

$82.99

per night

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La Quinta Inn & Suites by Wyndham Sioux Falls

4521 West 41st Street Sioux Falls, SD

Guests visiting Irene will find cozy-like comfort at La Quinta Inn & Suites by Wyndham Sioux Falls, where budget-friendly rooms start at $188.99, creating a warm and inviting space perfect for relaxation. Relax knowing La Quinta welcomes travelers of all kinds, with accessible rooms and facilities for a comfortable stay.

Stay at La Quinta Inn & Suites by Wyndham Sioux Falls for the perfect blend of peaceful surroundings and quick access to the cultural offerings of Irene. Discover Irene from the comfort of a hotel that makes every dollar count—reserve today!

  Call (855) 234-7135 to book with an agent.
  35.2 miles from Irene, SD 57073

Starting at

$188.99

per night

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Courtyard by Marriott Sioux Falls

4300 West Empire Pl Sioux Falls, SD

Enjoy the peaceful environment at Courtyard by Marriott Sioux Falls when visiting Irene, where comfortable rooms create a relaxing stay, with nightly rates beginning at $208.99. Leverage Courtyard's comprehensive business services, including convenient printing, faxing, and courier services, to keep up with work demands.

Whether you're visiting for business or leisure, Courtyard by Marriott Sioux Falls ensures you can relax while still being close to Irene's activities. Get ready for a Irene adventure with a hotel that adds value to your travels—book today!

  Call (855) 239-5277 to book with an agent.
  35.2 miles from Irene, SD 57073

Starting at

$208.99

per night

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SpringHill Suites by Marriott Sioux Falls

4304 West Empire Pl Sioux Falls, SD

Relax at SpringHill Suites by Marriott Sioux Falls as you explore Irene, where restful rooms create a comfortable stay, with nightly rates starting from a welcoming $198.00. Pull-out sofa beds at SpringHill Suites add flexibility to your accommodations, ideal for families or extra guests.

Find your serene getaway at SpringHill Suites by Marriott Sioux Falls, where the calm of your stay is paired with the convenience of Irene's top sights. Uncover Irene lodging that turns your trip into an unforgettable experience—secure now!

  Call (855) 233-7850 to book with an agent.
  35.3 miles from Irene, SD 57073

Starting at

$198.00

per night

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Baymont by Wyndham Sioux Falls

3200 South Meadow Avenue Sioux Falls, SD

With rooms beginning at $144.99, Baymont by Wyndham Sioux Falls provides inviting accommodations for guests bound for Irene, creating a welcoming, comfortable environment. Experience the comfort of Baymont by Wyndham’s blackout curtains, ensuring a good night's sleep by blocking out unwanted light.

At Baymont by Wyndham Sioux Falls, you can rest in peaceful surroundings while keeping the lively streets of Irene within easy reach. Take advantage of Irene travel with lodging that delivers exceptional value—book today!

  Call (855) 236-8982 to book with an agent.
  35.3 miles from Irene, SD 57073

Starting at

$144.99

per night

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