The best deals on hotels when visiting Cairo in Illinois.

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Top 24 Hotels In Cairo, Illinois 62914

Quality Inn Cairo I-57

13201 Kessler Road Cairo, IL

Guests bound for Cairo will appreciate the inviting accommodations at Quality Inn Cairo I-57, where easygoing rooms start at $80.00, creating a welcoming space for rest. Feel the warmth of Quality Inn's hospitality, with staff committed to providing a memorable and comfortable stay.

At Quality Inn Cairo I-57, guests are close enough to downtown Cairo for a quick drive to the city’s top destinations while still enjoying a quieter stay. Embrace a worry-free Cairo adventure with practical, inviting lodging—reserve your room now!

  Call (855) 234-2997 to book with an agent.
  2.5 miles from Cairo, IL 62914

Starting at

$80.00

per night

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Eagle Inn Charleston

2811 East Marshall Street Charleston, MO

Guests bound for Cairo will find budget-friendly comfort at Eagle Inn Charleston, where inviting rooms start at $69.29, creating a clean and welcoming space ideal for relaxation. Experience reliable comfort in rooms that offer standard amenities, ensuring a pleasant and budget-conscious stay.

The relaxing surroundings at Eagle Inn Charleston offer a restful retreat, with downtown Cairo a convenient drive away for easy access to the city’s best spots. Plan your Cairo travels with comfort and affordability—book your room today!

  Call (855) 233-7850 to book with an agent.
  9.1 miles from Cairo, IL 62914

Starting at

$69.29

per night

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Super 8 by Wyndham Charleston / Sikeston East MO

310 South Story St Charleston, MO

With budget-friendly rooms beginning at $57.99, Super 8 by Wyndham Charleston / Sikeston East MO provides inviting accommodations for travelers to Cairo, creating a comfortable and welcoming space. Rest in freshly updated rooms at Super 8, where renovations and modern amenities contribute to a pleasant and restful environment.

From Super 8 by Wyndham Charleston / Sikeston East MO, a short drive takes guests into downtown Cairo, where they can explore the city’s highlights and retreat to a quieter stay. Enjoy enhanced comfort at a great price for your Cairo travels—secure now!

  Call (855) 233-7850 to book with an agent.
  9.8 miles from Cairo, IL 62914

Starting at

$57.99

per night

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Quality Inn Charleston Sikeston

102 Drake St Charleston, MO

With budget-friendly rooms from $66.99, Quality Inn Charleston Sikeston provides inviting comfort for travelers bound for Cairo, creating a warm, inviting environment perfect for unwinding. Unwind in the comfort of Quality Inn's rooms, each outfitted with cozy bedding and thoughtful amenities for a restful sleep.

Travelers can unwind in the peaceful atmosphere of Quality Inn Charleston Sikeston, while the attractions of downtown Cairo are a quick drive away. Step into Cairo comfort with inviting, cost-effective lodging—book your room now!

  Call (855) 239-4019 to book with an agent.
  11.5 miles from Cairo, IL 62914

Starting at

$66.99

per night

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La Center Motel

474 West Kentucky Dr La Center, KY

For an affordable and welcoming stay, La Center Motel offers budget-friendly rooms with rates from $65.99, creating a comfortable space perfect for guests bound for Cairo. Enjoy the essentials in rooms that deliver practical comfort, making your stay both convenient and budget-friendly.

For a relaxing stay, La Center Motel offers quiet surroundings while keeping downtown Cairo accessible for a day of sightseeing. Choose a cost-conscious, inviting stay for your Cairo visit—reserve today!

  Call (855) 234-5074 to book with an agent.
  12.0 miles from Cairo, IL 62914

Starting at

$65.99

per night

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Regency Inn

128 CHEEKWOOD LN Ullin, IL

Guests bound for Cairo will enjoy affordable comfort at Regency Inn, where rooms start at $94.99, providing a clean, welcoming environment ideal for relaxation. Stay in a room that offers practical comfort and essential amenities, ensuring a pleasant and affordable visit.

A relaxing stay awaits at Regency Inn, where guests can enjoy quiet surroundings while still being within reach of downtown Cairo. Enjoy Cairo adventures with a budget-conscious, comfortable hotel—reserve now!

  Call (855) 234-5074 to book with an agent.
  18.3 miles from Cairo, IL 62914

Starting at

$94.99

per night

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Country Yard Inn&Suite

110 South Interstate Drive Sikeston, MO

Guests traveling to Cairo will find relaxed, budget-conscious comfort at Country Yard Inn&Suite, where rooms start at $54.99, creating a warm and inviting space for rest. Enjoy a stay that focuses on providing the essentials, with rooms that are equipped for comfort and practicality.

Take advantage of spacious rooms and a tranquil atmosphere at Country Yard Inn&Suite, while still being close enough to enjoy Cairo. Choose value and comfort for your Cairo travels—book your affordable stay now!

  Call (855) 235-0725 to book with an agent.
  20.8 miles from Cairo, IL 62914

Starting at

$54.99

per night

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Best Western Plus Sikeston

120 South Interstate Drive Sikeston, MO

At Best Western Plus Sikeston, travelers bound for Cairo will find budget-conscious accommodations with rooms starting at $80.99, creating a warm, welcoming environment. Relax with the book-lending program at Best Western Plus, allowing you to borrow and read books during your stay.

At Best Western Plus Sikeston, guests are treated to a peaceful environment with the added bonus of being close to the energy of Cairo. Make the most of your Cairo travels with practical, inviting hotel options—lock in now!

  Call (855) 239-4019 to book with an agent.
  20.8 miles from Cairo, IL 62914

Starting at

$80.99

per night

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Days Inn&Suites by Wyndham Sikeston

220 South Interstate Dr Sikeston, MO

At Days Inn&Suites by Wyndham Sikeston, guests visiting Cairo can enjoy warm-hearted, affordable rooms starting at $64.99, creating a clean and inviting environment for a peaceful stay. Experience the peace of mind with Days Inn's enhanced cleaning protocols, ensuring a safe and comfortable environment.

Recharge at Days Inn&Suites by Wyndham Sikeston, a serene haven situated perfectly for guests who want to explore Cairo at their own pace. Stay comfortable and budget-savvy on your Cairo visit—lock in your room today!

  Call (855) 239-4019 to book with an agent.
  20.9 miles from Cairo, IL 62914

Starting at

$64.99

per night

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Travel Inn & Suites Sikeston / Miner (i-55 Exit 67)

100 Matthews Lane Sikeston, MO

For an affordable stay near Cairo, Travel Inn & Suites Sikeston / Miner (i-55 Exit 67) offers inviting accommodations with rooms beginning at $62.99, creating a clean and comfortable space. Enjoy accommodations that add a touch of luxury and comfort, making your stay pleasant without compromising on value.

Discover your peaceful sanctuary at Travel Inn & Suites Sikeston / Miner (i-55 Exit 67), where the calm of your stay is enhanced by the proximity to Cairo's top spots. Choose accommodations in Cairo that offer a great blend of value and comfort—book now!

  Call (855) 234-2997 to book with an agent.
  21.1 miles from Cairo, IL 62914

Starting at

$62.99

per night

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Comfort Inn & Suites Sikeston I-55

109 Matthews Ln Sikeston, MO

At Comfort Inn & Suites Sikeston I-55, travelers headed to Cairo will find peaceful comfort with rooms starting at $97.99, creating a warm and inviting environment ideal for relaxation. Stay refreshed with Comfort Inn's air-conditioned rooms, ensuring a comfortable environment no matter the weather.

Step into relaxation at Comfort Inn & Suites Sikeston I-55, a quiet retreat where you can explore Cairo's excitement whenever you choose. Discover a Cairo stay that makes every moment worthwhile with practical, cost-saving lodging—lock in today!

  Call (855) 236-8982 to book with an agent.
  21.1 miles from Cairo, IL 62914

Starting at

$97.99

per night

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Super 8 by Wyndham Sikeston / Miner Area

2609 East Malone Ave Sikeston, MO

For those bound for Cairo, Super 8 by Wyndham Sikeston / Miner Area offers budget-friendly accommodations with rooms starting at $60.99, creating a warm, inviting space for guests to unwind. Find Super 8 locations conveniently close to everything from scenic highways to vibrant city centers, enhancing your travel plans.

Escape to Super 8 by Wyndham Sikeston / Miner Area, where a restful environment ensures a peaceful stay with Cairo just a quick trip away. Make the most of your Cairo trip with cost-saving, inviting lodging—secure today!

  Call (855) 233-7850 to book with an agent.
  21.3 miles from Cairo, IL 62914

Starting at

$60.99

per night

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Hampton Inn Sikeston

1240 Commerce Drive Sikeston, MO

Guests bound for Cairo can unwind at Hampton Inn Sikeston, where inviting rooms start at $148.99, creating a warm and welcoming space perfect for relaxation. Welcome to Hampton by Hilton, where you're greeted with a smile and the promise of a comfortable, value-packed stay.

Experience a refreshing stay at Hampton Inn Sikeston, with both spacious accommodations and convenient access to Cairo. Take your Cairo trip to the next level with well-thought-out, budget-friendly lodging—lock in today!

  Call (855) 235-0725 to book with an agent.
  24.3 miles from Cairo, IL 62914

Starting at

$148.99

per night

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Holiday Inn Express & Suites Sikeston Southwest an IHG Hotel

115 Hospitality Dr Sikeston, MO

At Holiday Inn Express & Suites Sikeston Southwest an IHG Hotel, travelers to Cairo can enjoy serene comfort with rooms beginning at $159.00, creating a welcoming environment ideal for a restful stay. Enjoy the reassurance of Holiday Inn Express's doctor-on-call service, ensuring medical assistance is readily available if needed.

Enjoy a peaceful stay at Holiday Inn Express & Suites Sikeston Southwest an IHG Hotel, where guests can relax and still visit Cairo's lively streets whenever they choose. Unwind in Cairo at a hotel that provides comfort and value in every way—reserve today!

  Call (855) 239-5277 to book with an agent.
  24.3 miles from Cairo, IL 62914

Starting at

$159.00

per night

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Harrahs Metropolis Hotel & Casino

100 East Front St Metropolis, IL

Step into a enchanting retreat at Harrahs Metropolis Hotel & Casino near Cairo, where quality accommodations provide warmth, with budget-friendly rates from $102.99. Stay in rooms that elevate your experience with luxury amenities and impeccable service, making every moment enjoyable.

At Harrahs Metropolis Hotel & Casino, you can rest easy knowing Cairo is just a short drive away for whenever you’re ready to explore. Enjoy your Cairo visit with accommodations that provide everything you could desire—reserve now!

  Call (855) 239-4019 to book with an agent.
  26.5 miles from Cairo, IL 62914

Starting at

$102.99

per night

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Econo Lodge Paducah West I-24

5120 Hinkleville Road Paducah, KY

Guests traveling to Cairo can unwind at Econo Lodge Paducah West I-24, where budget-friendly rooms start at $56.99, providing a warm and welcoming space perfect for rest. Utilize the comprehensive on-site amenities at Econo Lodge, tailored to meet the needs of modern travelers looking for value and convenience.

Relax and recharge at Econo Lodge Paducah West I-24, a peaceful spot where you can rest comfortably and still explore Cairo's attractions. Stay comfortably and save on your Cairo adventure—lock in your room today!

  Call (855) 235-0725 to book with an agent.
  27.7 miles from Cairo, IL 62914

Starting at

$56.99

per night

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Baymont by Wyndham Paducah

5300 Old Cairo Rd Paducah, KY

Guests bound for Cairo can unwind at Baymont by Wyndham Paducah, where inviting rooms start at $54.00, creating a warm and comfortable space ideal for relaxation. Relax with the peace and quiet of Baymont by Wyndham’s strategically located properties, away from the noise of the city yet convenient to key attractions.

Find your ideal retreat at Baymont by Wyndham Paducah, a calming spot that’s just a short drive away from the vibrant streets of Cairo. Stay smart in Cairo with a hotel that offers comfort and peace of mind—secure now!

  Call (855) 239-5277 to book with an agent.
  27.8 miles from Cairo, IL 62914

Starting at

$54.00

per night

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Quality Suites Paducah I-24

2880 James Sanders Blvd Paducah, KY

At Quality Suites Paducah I-24, travelers to Cairo will find budget-friendly rooms with rates starting at $81.99, creating a clean, welcoming environment perfect for rest. Relax in rooms that combine comfort with practical luxury, offering more amenities to enhance your stay without the high costs.

Unwind at Quality Suites Paducah I-24, a restful retreat situated just a short drive from the vibrant offerings of Cairo. Relax and recharge in Cairo with a hotel that’s both inviting and economical—secure now!

  Call (855) 234-7135 to book with an agent.
  27.8 miles from Cairo, IL 62914

Starting at

$81.99

per night

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Mustang Inn

5006 Hinkleville Rd Paducah, KY

At Mustang Inn, travelers visiting Cairo can enjoy inviting accommodations with rooms starting at $59.99, creating a warm, welcoming environment for rest. Experience a touch of extra comfort and convenience in rooms that cater to your needs for a relaxing and affordable stay.

At Mustang Inn, the peaceful atmosphere offers guests a restful stay while keeping the attractions of Cairo close by. Make your Cairo trip stress-free and comfortable with a budget-friendly hotel—lock in now!

  Call (855) 233-7850 to book with an agent.
  27.9 miles from Cairo, IL 62914

Starting at

$59.99

per night

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Country Inn & Suites by Radisson Paducah KY

145 Mcbride Ln Paducah, KY

For an affordable and comfortable stay, Country Inn & Suites by Radisson Paducah KY offers inviting rooms with rates starting at $93.99, creating a clean, welcoming environment for guests. Relax with the children’s play areas at Country Inn & Suites, designed to keep young guests entertained and engaged.

Find serenity at Country Inn & Suites by Radisson Paducah KY, where calm lodgings are matched with the convenience of being close to Cairo's top spots. Make your Cairo adventure simple and enjoyable with inviting hotel options—lock in now!

  Call (855) 239-4019 to book with an agent.
  27.9 miles from Cairo, IL 62914

Starting at

$93.99

per night

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Courtyard by Marriott Cape Girardeau Downtown

400 Broadway St. Cape Girardeau, MO

Find a warm retreat at Courtyard by Marriott Cape Girardeau Downtown as you explore Cairo, where quality rooms provide comfort and relaxation, with inviting nightly rates beginning at $174.99. Stay connected with Courtyard's virtual concierge service, offering personalized assistance and recommendations via your mobile device.

Enjoy a quiet escape at Courtyard by Marriott Cape Girardeau Downtown, where guests can recharge and still visit Cairo's bustling streets whenever they choose. Find the ideal base for your Cairo trip with accommodations that deliver on quality—lock in today!

  Call (855) 235-6136 to book with an agent.
  27.9 miles from Cairo, IL 62914

Starting at

$174.99

per night

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Candlewood Suites Paducah an IHG Hotel

3940 Coleman Crossing Cir Paducah, KY

Guests bound for Cairo will find inviting comfort at Candlewood Suites Paducah an IHG Hotel, with rooms starting at $129.00, creating a warm and welcoming space perfect for relaxation. Gyms at Candlewood Suites are fully equipped to support a variety of fitness routines, catering to all levels of activity.

Whether you're here for business or pleasure, Candlewood Suites Paducah an IHG Hotel provides a peaceful setting that keeps Cairo within easy reach. Get the rest and comfort you deserve while exploring Cairo—secure your hotel room now!

  Call (855) 239-5277 to book with an agent.
  28.0 miles from Cairo, IL 62914

Starting at

$129.00

per night

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Fairfield Inn & Suites by Marriott Paducah

3950 Coleman Crossing Circle Paducah, KY

Guests bound for Cairo can enjoy budget-friendly comfort at Fairfield Inn & Suites by Marriott Paducah, where homely rooms start at $144.99, creating a welcoming space perfect for relaxation. Enjoy the practicality and convenience of Fairfield's in-room amenities, designed to enhance both short and extended stays.

Discover relaxation at Fairfield Inn & Suites by Marriott Paducah, where quiet comfort meets convenient access to the bustling attractions of Cairo. Find your ideal hotel for exploring Cairo with comfort and convenience—book today!

  Call (855) 235-6136 to book with an agent.
  28.1 miles from Cairo, IL 62914

Starting at

$144.99

per night

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La Quinta Inn & Suites by Wyndham Paducah

3960 Coleman Crossing Cir Paducah, KY

Guests bound for Cairo can unwind at La Quinta Inn & Suites by Wyndham Paducah, where inviting rooms start at $126.99, creating a warm and comfortable space ideal for relaxation. Relax in La Quinta’s modern rooms, complete with comfortable bedding and a quiet atmosphere for a restful night’s sleep.

Discover the convenience of La Quinta Inn & Suites by Wyndham Paducah, a peaceful location with Cairo's attractions accessible whenever you're ready to explore. Make Cairo travel feel effortless with a cost-effective, welcoming hotel—book now!

  Call (855) 239-4019 to book with an agent.
  28.1 miles from Cairo, IL 62914

Starting at

$126.99

per night

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