Top 24 Hotels In Clayton, Missouri 63105

Step into unparalleled luxury at The Ritz Carlton St. Louis as you explore Clayton, where premier surroundings ensure a remarkable stay, with rates starting from $639.99. Discover a golfer's paradise at Ritz-Carlton's premier golf resorts, where championship courses and pro-level facilities await in breathtaking settings.

Stay close to Clayton’s key sights and attractions at The Ritz Carlton St. Louis, where you’ll be minutes from the excitement yet still enjoy a tranquil environment. Experience Clayton in luxury with a hotel that promises a stay like no other—secure now!

With an ambiance of refined grace, Le Méridien St. Louis Clayton near Clayton offers elegant accommodations, with rates beginning at an affordable $189.99 per night. Refresh your body and mind with Le Méridien’s in-room wellness options, from spa services to wellness guides.

Nestled near Clayton’s vibrant center, Le Méridien St. Louis Clayton ensures guests can enjoy a relaxing stay while remaining close to the city’s highlights. Find the perfect escape in Clayton with accommodations that make luxury the standard—lock in today!

Embrace a delightful stay at Clayton Plaza Hotel & Extended Stay near Clayton, where inviting rooms provide warmth and relaxation, with nightly rates starting at an affordable $100.99. Enjoy the peace of mind with Extended Stay America’s secure property access, ensuring guest safety and privacy throughout your stay.

A few blocks from Clayton’s dynamic downtown area, Clayton Plaza Hotel & Extended Stay is perfectly found for those looking to discover the city’s vibrant culture and entertainment. Step into a world of sophistication in Clayton with a hotel that makes luxury feel effortless—book today!

Relax in the inviting surroundings of AC Hotel St. Louis Clayton as you visit Clayton, where comfortable accommodations provide a peaceful stay, with rates beginning at $164.99. Savor the unique flavors of AC Hotels' mixology classes, where guests can learn to craft their own signature cocktails.

The city center is only a short walk from AC Hotel St. Louis Clayton, making it easy for guests to enjoy Clayton’s best sights, shops, and eateries. Plan a relaxing Clayton getaway with accommodations that prioritize your needs—book today!

Those visiting Clayton will find Seven Gables St. Louis West a Tribute Portfolio Hotel a intimate escape, where quality rooms offer warmth and relaxation, with inviting rates starting at $229.99. Explore the eclectic and dynamic public spaces at Tribute Portfolio hotels, designed to foster connections and creativity.

Seven Gables St. Louis West a Tribute Portfolio Hotel offers guests the perfect blend of convenience and relaxation, with downtown Clayton never far away for easy access to the city’s top spots. Discover a Clayton hotel that makes every detail feel luxurious and well-crafted—secure now!

Stay affordably at Residence Inn by Marriott St. Louis Clayton on your trip to Clayton, where inviting rooms create a restful retreat, with budget-friendly rates beginning at $169.99. Ask Residence Inn staff for insider tips on dining and entertainment, ensuring you experience the best of the local area.

Staying at Residence Inn by Marriott St. Louis Clayton ensures guests are close enough to downtown Clayton for easy access, while still enjoying a quieter retreat. Find peace of mind in Clayton with a hotel that offers modern amenities and thoughtful service—secure now!

Find restful accommodations at Hampton Inn & Suites Clayton / St. Louis Galleria Area as you journey to Clayton, where inviting rooms offer comfort, with rates beginning at an affordable $133.99 per night. Feel secure with 24-hour front desk service at Hampton, where staff are available day and night to assist with any needs.

At Hampton Inn & Suites Clayton / St. Louis Galleria Area, you’re always close to the action, with downtown Clayton just a short trip away for easy access to the city’s best spots. Get the best of Clayton with a hotel that makes luxury accessible to everyone—book today!

Stay affordably at Homewood Suites by Hilton St. Louis Galleria on your journey to Clayton, where soft rooms create a peaceful escape, with budget-friendly rates beginning at $120.99. Take advantage of Homewood Suites' complimentary grocery delivery service, allowing you to have your kitchen stocked upon arrival or during your stay.

Homewood Suites by Hilton St. Louis Galleria offers a great location for exploring Clayton, where the city’s downtown attractions are easily reached with minimal effort. Discover a hotel in Clayton that enhances your adventure with unparalleled value—secure now!

Guests visiting Clayton will find restorative comfort at MainStay Suites St. Louis Galleria, with rooms beginning at $113.99, creating a warm and inviting space ideal for rest. Stay fit with MainStay Suites’ on-site fitness classes, including yoga and pilates, tailored to guest wellness.

Guests at MainStay Suites St. Louis Galleria can enjoy the flexibility of visiting downtown Clayton whenever they like, with the city’s top attractions just a short trip from the hotel. Make every moment in Clayton memorable with a hotel that fits your budget—reserve today!

Choose Courtyard by Marriott St. Louis Brentwood for your journey to Clayton, where soft rooms offer a comfortable escape, with rates beginning at an inviting $139.99 per night. Relax with the peace of mind provided by Courtyard's secure parking options, ensuring your vehicle is safe during your stay.

Guests staying at Courtyard by Marriott St. Louis Brentwood can quickly reach downtown Clayton, offering a seamless blend of convenience and comfort for travelers. Take your Clayton experience to the next level with a hotel that delivers on all fronts—lock in today!

Guests bound for Clayton will find easygoing accommodations at The Charles F. Knight Center, with rooms beginning at $179.99, creating a welcoming, comfortable atmosphere ideal for relaxation. Relax in rooms that are designed for travelers seeking practical accommodations with a focus on cleanliness and comfort.

Guests staying at The Charles F. Knight Center will love the flexibility of being close to downtown Clayton, with easy access to the city’s best destinations. Take your Clayton experience up a notch with well-appointed, wallet-friendly lodging—secure now!

Find restful accommodations at TownePlace Suites by Marriott Brentwood on your journey to Clayton, with inviting rooms starting from an affordable $154.99 per night, perfect for relaxation. Choose TownePlace Suites by Marriott for an optimal balance of comfort, convenience, and value during extended stays.

From TownePlace Suites by Marriott Brentwood, guests can quickly reach downtown Clayton, where the city’s most vibrant destinations are just a short journey away. Find out how comfortable Clayton can be with a hotel that delivers exceptional service—lock in today!

Those visiting Clayton will love the grandeur of The Cheshire, where thoughtfully designed rooms promise elegance, with nightly rates beginning at just $152.02. Relax in accommodations where luxury meets innovation, featuring smart technology and plush interiors for an exceptional stay.

The Cheshire provides the perfect location for those who want to explore Clayton, with downtown just a short trip from the hotel. Step into a Clayton hotel that makes traveling in style look effortless—secure your room now!

Stay affordably at SpringHill Suites St. Louis Brentwood on your trip to Clayton, where cushy accommodations create a warm atmosphere, with inviting rates beginning at $139.99. Earn rewards with Marriott Bonvoy™ at SpringHill Suites, enhancing your travel with exclusive benefits and free nights.

SpringHill Suites St. Louis Brentwood offers guests the flexibility to walk to downtown Clayton or enjoy a quick drive to the city’s best restaurants and attractions. Enjoy a Clayton hotel that offers more than just a stay—it’s an experience to remember—book today!

Relax in the lavish surroundings of Moonrise Hotel on your trip to Clayton, where serene accommodations set the tone for luxury, with nightly rates from $160.00. Enjoy rooms that offer the pinnacle of luxury, where traditional elegance meets modern sophistication in a serene setting.

With downtown Clayton just a short drive away, guests at Moonrise Hotel can explore the city’s top attractions while enjoying a quieter, more peaceful stay. Step into your Clayton escape with a hotel that delivers unparalleled luxury—book today!

With rooms starting at $139.07, Hampton Inn & Suites St. Louis at Forest Park provides inviting accommodations for guests traveling to Clayton, creating a cushy, welcoming environment. Enjoy the refreshing simplicity of Hampton’s tea and coffee-making facilities in each room, perfect for starting your day right.

With downtown Clayton only a short drive away, guests at Hampton Inn & Suites St. Louis at Forest Park can easily visit the city’s most popular spots while enjoying a quieter stay. Discover Clayton with a hotel that offers unbeatable comfort at a great value—lock in now!

Stay affordably at Forest Park Hotel by MDR on your trip to Clayton, where mellifluous rooms create a welcoming environment, with room rates starting from $80.99. Relax in accommodations that provide a blend of modern amenities and traditional comfort, ensuring a memorable stay.

With a quick drive to downtown Clayton, guests at Forest Park Hotel by MDR can experience the best of the city while staying in a quieter, more relaxed area. Relax in a Clayton hotel that turns your trip into a delightful experience—lock in today!

With rates beginning at $79.00, Red Roof Inn PLUS+ St. Louis Forest Park / Hampton Ave provides budget-friendly accommodations for travelers headed to Clayton, creating a welcoming space ideal for relaxation. Experience hassle-free check-outs at Red Roof Inn, making it easier to get on the road early without delay.

At Red Roof Inn PLUS+ St. Louis Forest Park / Hampton Ave, guests are never far from downtown Clayton, where a quick drive takes them into the heart of the action for easy exploration. Embrace added comfort and convenience while exploring Clayton—book your hotel now!

Those traveling to Clayton will appreciate the allure of The Royal Sonesta Chase Park Plaza St. Louis, where luxury and tranquility blend seamlessly, with rates from $279.00. Experience the convenience and comfort of Sonesta’s transportation services, including shuttles and car rentals to help you explore.

With downtown Clayton just a short drive from The Royal Sonesta Chase Park Plaza St. Louis, guests can explore the city with ease while returning to a quieter setting afterward. Find true tranquility in Clayton with a hotel that perfects the art of relaxation—secure now!

Enjoy an elegant retreat at AC Hotel St. Louis Central West End as you journey to Clayton, where inviting rooms offer relaxation, with affordable rates starting at $164.00. Discover the vibrant energy of AC Hotels' DJ nights, where local talent spins tracks for a lively evening atmosphere.

With downtown Clayton just a short drive away, guests at AC Hotel St. Louis Central West End can explore the city’s most vibrant spots while staying in a quieter location. Find out how special Clayton can be with a hotel that caters to your every need—lock in today!

Embrace comfort and sophistication at DoubleTree by Hilton St. Louis Forest Park on your trip to Clayton, where delightful rooms provide quality, with inviting nightly rates beginning at $150.99. Shop in style at DoubleTree by Hilton's boutique store, featuring a selection of unique local items and essential travel products.

From DoubleTree by Hilton St. Louis Forest Park, guests can quickly reach downtown Clayton, making it simple to explore the city’s top spots while staying in a quieter area. Relax and rejuvenate in Clayton with accommodations that provide an unparalleled experience—secure now!

For an affordable and restful stay near Clayton, Holiday Inn Express St. Louis Central West End an IHG Hotel offers budget-friendly accommodations with rooms starting at $129.00, creating a welcoming space. Appreciate the modern amenities in every room, including flat-screen TVs, convenient charging stations, and comfortable work areas.

Guests staying at Holiday Inn Express St. Louis Central West End an IHG Hotel can quickly reach downtown Clayton by car, where the city’s most popular sights are always nearby. Take the guesswork out of Clayton travel with a hotel that delivers on value—lock in today!

Unwind at Home2 Suites by Hilton St. Louis / Forest Park near Clayton, where inviting rooms offer warmth and comfort, with budget-friendly nightly rates starting from just $132.99. Relish in the modern and spacious suite bathrooms equipped with environmentally friendly fixtures and amenities.

With downtown Clayton just a short drive away, guests at Home2 Suites by Hilton St. Louis / Forest Park can easily explore the city’s top spots while enjoying a quieter stay. Discover a hotel in Clayton that enhances your adventure with unparalleled value—secure now!

Step into a luxurious getaway at Hilton St. Louis Frontenac near Clayton, where refined accommodations make every moment special, with enticing rates starting from $147.99. Find tranquility in Hilton's beautifully landscaped gardens and outdoor spaces, perfect for unwinding after a busy day.

With a quick drive into downtown Clayton, guests at Hilton St. Louis Frontenac can experience the best of the city while enjoying a quieter stay. Find out how breathtaking Clayton can be with a hotel that keeps you relaxed and pampered—reserve now!