The best deals on hotels when visiting Cypress Crossroads in South Carolina.

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Top 24 Hotels In Cypress Crossroads, South Carolina 29069

Americas Best Value Inn Bishopville

27 Charlene Ln Bishopville, SC

With rooms starting at $103.99, Americas Best Value Inn Bishopville is an affordable choice for guests visiting Cypress Crossroads, creating a clean, welcoming space perfect for a peaceful stay. Enjoy the convenience of Americas Best Value Inn's locations, often found close to airports, making travel logistics smoother.

Guests at Americas Best Value Inn Bishopville will appreciate how close they are to downtown Cypress Crossroads, where a short drive delivers them to the city’s best spots. Make the most of your Cypress Crossroads travels with affordable, welcoming accommodations—book now!

  Call (855) 236-8982 to book with an agent.
  4.9 miles from Cypress Crossroads, SC 29069

Starting at

$103.99

per night

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Red Roof Inn Bishopville

1135 Sumter Hwy Bishopville, SC

Guests visiting Cypress Crossroads can unwind in budget-conscious comfort at Red Roof Inn Bishopville, with rooms beginning at $84.99, creating a clean and welcoming space. Experience the cozy ambiance of Red Roof Inn's rooms, offering a warm and inviting space to unwind.

With a convenient drive into downtown Cypress Crossroads, guests at Red Roof Inn Bishopville can balance city adventures with a quieter, more peaceful stay. Make the most of Cypress Crossroads with a comfortable, affordable hotel—book your room now!

  Call (855) 233-0132 to book with an agent.
  7.2 miles from Cypress Crossroads, SC 29069

Starting at

$84.99

per night

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The Landmark Inn

1301 South 4th Street Hartsville, SC

Guests bound for Cypress Crossroads will find warm-hearted accommodations at The Landmark Inn, where rooms start at $85.00, creating a warm and inviting environment ideal for relaxation. Relax in rooms that cater to budget-conscious guests, offering a comfortable and clean environment without unnecessary extras.

At The Landmark Inn, the quiet atmosphere offers a restful stay, with the added convenience of downtown Cypress Crossroads being nearby for sightseeing. Stay comfortably in Cypress Crossroads with a hotel that delivers on quality and savings—book today!

  Call (855) 239-4019 to book with an agent.
  10.5 miles from Cypress Crossroads, SC 29069

Starting at

$85.00

per night

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Hampton Inn & Suites Hartsville

203 East Carolina Ave. Hartsville, SC

With rates from $170.99, Hampton Inn & Suites Hartsville provides easygoing comfort for guests traveling to Cypress Crossroads, creating a warm and welcoming environment ideal for rest. Appreciate the multi-use furniture in Hampton’s guest rooms, where space-saving designs ensure comfort and functionality.

Unwind in the calm atmosphere of Hampton Inn & Suites Hartsville, where quiet surroundings create a relaxing stay, and downtown Cypress Crossroads is still nearby. Choose accommodations in Cypress Crossroads that offer a great blend of value and comfort—book now!

  Call (855) 233-7850 to book with an agent.
  11.5 miles from Cypress Crossroads, SC 29069

Starting at

$170.99

per night

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Fairfield Inn by Marriott Hartsville

200 South 4th St Hartsville, SC

At Fairfield Inn by Marriott Hartsville, guests bound for Cypress Crossroads will enjoy budget-friendly comfort with rooms starting at $169.99, creating a warm and welcoming atmosphere. Indulge in Fairfield's calming decor, inspired by the beauty of nature and designed to create a calm and restorative environment.

For travelers looking for peace, Fairfield Inn by Marriott Hartsville offers quiet surroundings while keeping downtown Cypress Crossroads just a convenient drive away. Stay refreshed and relaxed in Cypress Crossroads with inviting, budget-friendly lodging—reserve now!

  Call (855) 234-2997 to book with an agent.
  11.6 miles from Cypress Crossroads, SC 29069

Starting at

$169.99

per night

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Raceway Inn

705 Washington St Darlington, SC

With rates from $60.99, Raceway Inn provides alluring comfort for guests traveling to Cypress Crossroads, creating a warm and welcoming environment ideal for rest. Experience a stay that offers more in terms of amenities and comfort, providing an enhanced visit at a budget-friendly price.

For a restful escape, Raceway Inn provides peaceful surroundings with the convenience of downtown Cypress Crossroads still being nearby. Enjoy the best of Cypress Crossroads with accommodations that enhance your travel experience—reserve now!

  Call (855) 236-8982 to book with an agent.
  15.3 miles from Cypress Crossroads, SC 29069

Starting at

$60.99

per night

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Super 8 by Wyndham Florence SC I-95 North / Hwy 76

3783A West Palmetto Street Florence, SC

With rooms beginning at $50.99, Super 8 by Wyndham Florence SC I-95 North / Hwy 76 is a convenient choice for travelers to Cypress Crossroads, providing budget-conscious comfort in a warm, inviting setting. Relax knowing Super 8 focuses on the essentials, providing straightforward amenities that matter most to travelers.

For a peaceful retreat, Super 8 by Wyndham Florence SC I-95 North / Hwy 76 offers a quiet setting with the convenience of downtown Cypress Crossroads being just a drive away. Plan a practical, budget-friendly stay for your Cypress Crossroads travels—book today!

  Call (855) 239-5277 to book with an agent.
  15.8 miles from Cypress Crossroads, SC 29069

Starting at

$50.99

per night

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Homewood Suites by Hilton Florence

3450 West Radio Drive Florence, SC

Enjoy a warm retreat at Homewood Suites by Hilton Florence on your trip to Cypress Crossroads, where quality rooms provide comfort, with nightly rates starting at a welcoming $156.99. Appreciate the convenience of Homewood Suites' on-demand housekeeping services, available to keep your suite tidy on your schedule.

Travelers can relax at Homewood Suites by Hilton Florence, where quiet surroundings offer a peaceful retreat and downtown Cypress Crossroads remains within reach. Relax in a Cypress Crossroads hotel that turns your trip into a delightful experience—lock in today!

  Call (855) 239-4019 to book with an agent.
  16.5 miles from Cypress Crossroads, SC 29069

Starting at

$156.99

per night

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Staybridge Suites Florence Civic Center an IHG Hotel

150 Westpark Drive Florence, SC

Enjoy a gentle ambiance at Staybridge Suites Florence Civic Center an IHG Hotel as you travel to Cypress Crossroads, where restful accommodations provide quality and warmth, with inviting rates from $191.96. Stay productive with spacious work desks and ergonomic chairs provided in every Staybridge suite.

At Staybridge Suites Florence Civic Center an IHG Hotel, guests can experience the calm of quiet surroundings, with the energy of downtown Cypress Crossroads still close by. Enjoy every aspect of your Cypress Crossroads trip with a hotel that keeps you feeling at home—book today!

  Call (855) 236-8982 to book with an agent.
  16.7 miles from Cypress Crossroads, SC 29069

Starting at

$191.96

per night

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Holiday Inn Express & Suites Florence I-95 & I-20 Civic Center an IHG Hotel

3440 West Radio Dr Florence, SC

At Holiday Inn Express & Suites Florence I-95 & I-20 Civic Center an IHG Hotel, guests bound for Cypress Crossroads can unwind in appealing accommodations with rooms starting at $144.00, creating a warm, welcoming atmosphere. Stay informed with Holiday Inn Express's digital concierge services, providing up-to-date information and recommendations for your visit.

Unwind at Holiday Inn Express & Suites Florence I-95 & I-20 Civic Center an IHG Hotel in a quiet setting, where downtown Cypress Crossroads is still within easy reach for a day of adventure. Maximize your Cypress Crossroads adventure with well-rounded, cost-effective accommodations—secure now!

  Call (855) 234-7135 to book with an agent.
  16.7 miles from Cypress Crossroads, SC 29069

Starting at

$144.00

per night

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Quality Inn&Suites Civic

150 Dunbarton Dr Florence, SC

Guests bound for Cypress Crossroads will find charming accommodations at Quality Inn&Suites Civic, where rooms start at $95.99, creating a warm and inviting environment ideal for relaxation. Take advantage of Quality Inn's early bird special offers, providing significant savings for advanced bookings.

Unwind at Quality Inn&Suites Civic in a quiet setting, where downtown Cypress Crossroads is still within easy reach for a day of adventure. Choose a hotel that makes Cypress Crossroads travel simple and relaxing—lock in your stay today!

  Call (855) 234-7135 to book with an agent.
  16.9 miles from Cypress Crossroads, SC 29069

Starting at

$95.99

per night

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Home2 Suites by Hilton Florence SC

900 Woody Jones Blvd Florence, SC

Enjoy the inviting ambiance of Home2 Suites by Hilton Florence SC as you visit Cypress Crossroads, where restful rooms provide quality and relaxation, with affordable rates beginning at $138.99. Stay fit with various fitness options including TRX training systems in select Home2 Suites' gyms.

The serene setting at Home2 Suites by Hilton Florence SC makes for a peaceful stay, with downtown Cypress Crossroads still close enough for guests to explore the city. Enjoy seamless Cypress Crossroads travel with a hotel that ensures your comfort from start to finish—secure now!

  Call (855) 234-7135 to book with an agent.
  17.0 miles from Cypress Crossroads, SC 29069

Starting at

$138.99

per night

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Days Inn by Wyndham Florence Near Civic Center

140 Dunbarton Dr Florence, SC

Guests headed to Cypress Crossroads will appreciate the inviting comfort at Days Inn by Wyndham Florence Near Civic Center, where rooms start at $78.99, creating a clean, welcoming environment for relaxation. Choose Days Inn for family travel, with accommodations and amenities designed to make stays comfortable for guests of all ages.

Relax in the peaceful surroundings at Days Inn by Wyndham Florence Near Civic Center, where quiet comfort and easy access to downtown Cypress Crossroads meet. Enjoy a worry-free Cypress Crossroads adventure with budget-conscious, well-equipped lodging—book today!

  Call (855) 233-7850 to book with an agent.
  17.0 miles from Cypress Crossroads, SC 29069

Starting at

$78.99

per night

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Aloft Florence

820 WOODY JONES BOULEVARD Florence, SC

Stay at Aloft Florence near Cypress Crossroads for a soothing escape, where quality accommodations create a warm environment, with rates starting from a friendly $154.99. Experience a touch of luxury with rainforest showers in Aloft's bathrooms, providing a spa-like escape in the comfort of your room.

A calm retreat awaits at Aloft Florence, with downtown Cypress Crossroads remaining a quick drive away for all your city adventures. Stay effortlessly in Cypress Crossroads with a hotel that ensures your visit is perfect—lock in today!

  Call (855) 236-8982 to book with an agent.
  17.1 miles from Cypress Crossroads, SC 29069

Starting at

$154.99

per night

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Comfort Inn & Suites

527 Woody Jones Blvd Florence, SC

Guests bound for Cypress Crossroads can unwind at Comfort Inn & Suites, where inviting rooms start at $128.99, creating a warm and welcoming space perfect for relaxation. Appreciate the added convenience of complimentary parking, making your travels smoother and more stress-free.

Guests staying at Comfort Inn & Suites will enjoy the tranquil surroundings, while downtown Cypress Crossroads remains easily accessible by car. Uncover the best of Cypress Crossroads with a hotel that makes quality affordable—secure your room now!

  Call (855) 236-8982 to book with an agent.
  17.1 miles from Cypress Crossroads, SC 29069

Starting at

$128.99

per night

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Hampton Inn & Suites Florence Center

3000 West Radio Dr Florence, SC

Guests traveling to Cypress Crossroads will find Hampton Inn & Suites Florence Center a practical choice, with rooms beginning at $151.99, creating a clean and inviting environment ideal for relaxation. Ride around town with Hampton’s bike rental service, a fun and eco-friendly way to explore local sights and sounds.

Guests at Hampton Inn & Suites Florence Center can unwind in a tranquil setting, while knowing that downtown Cypress Crossroads is just a convenient drive away. Take advantage of Cypress Crossroads travel with a hotel that adds convenience to your journey—reserve today!

  Call (855) 234-7135 to book with an agent.
  17.1 miles from Cypress Crossroads, SC 29069

Starting at

$151.99

per night

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Residence Inn Marriott Florence

2660 Hospitality Blvd Florence, SC

Relax in the inviting ambiance of Residence Inn Marriott Florence near Cypress Crossroads, where enveloping accommodations create a peaceful escape, with affordable nightly rates from $214.99. Enjoy a refreshing swim in the pool at Residence Inn, an ideal way to relax after a busy day.

At Residence Inn Marriott Florence, guests can enjoy the quiet atmosphere while keeping downtown Cypress Crossroads within easy reach for a day of sightseeing. Find the perfect blend of comfort and affordability for your Cypress Crossroads adventure—book today!

  Call (855) 239-4019 to book with an agent.
  17.2 miles from Cypress Crossroads, SC 29069

Starting at

$214.99

per night

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Hilton Garden Inn Florence

2671 Hospitality Boulevard Florence, SC

Guests bound for Cypress Crossroads can unwind at Hilton Garden Inn Florence, where inviting rooms start at $125.99, creating a warm and comfortable space ideal for relaxation. Maintain your workout routine at Hilton Garden Inn's fitness center, featuring the latest equipment and open 24 hours for your convenience.

A quiet retreat at Hilton Garden Inn Florence provides rest and relaxation, with downtown Cypress Crossroads easily accessible for a day of adventure. Relax and make the most of Cypress Crossroads with a hotel that takes care of every detail—secure now!

  Call (855) 234-5074 to book with an agent.
  17.2 miles from Cypress Crossroads, SC 29069

Starting at

$125.99

per night

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SpringHill Suites by Marriott Florence

2670 Hospitality Blvd Florence, SC

Enjoy the welcoming atmosphere of SpringHill Suites by Marriott Florence as you explore Cypress Crossroads, where restful rooms provide comfort, with rates beginning at an accessible $152.99. Enjoy the daily complimentary breakfast at SpringHill Suites, offering a delicious start to your day with a variety of choices.

For those seeking both peace and proximity, SpringHill Suites by Marriott Florence offers quiet surroundings with downtown Cypress Crossroads accessible for city exploration. Take a break from the ordinary in Cypress Crossroads with a hotel that makes relaxation easy—book today!

  Call (855) 235-0725 to book with an agent.
  17.2 miles from Cypress Crossroads, SC 29069

Starting at

$152.99

per night

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Courtyard by Marriott Florence

2680 Hospitality Blvd Florence, SC

Enjoy a restful stay at Courtyard by Marriott Florence as you explore Cypress Crossroads, where warm-hearted rooms provide relaxation and warmth, with budget-friendly rates from $149.99 per night. Relax in the comfort of Courtyard's lounge chairs, strategically placed in common areas for reading, socializing, or simply enjoying the ambiance.

For a relaxing stay, Courtyard by Marriott Florence offers quiet surroundings while keeping downtown Cypress Crossroads accessible for a day of sightseeing. Discover the ideal way to explore Cypress Crossroads with accommodations that meet your needs—secure now!

  Call (855) 239-4019 to book with an agent.
  17.2 miles from Cypress Crossroads, SC 29069

Starting at

$149.99

per night

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Red Roof Inn Florence Civic Center

2690 David H McLeod Boulevard Florence, SC

At Red Roof Inn Florence Civic Center, guests visiting Cypress Crossroads can unwind in inviting accommodations with rooms from $69.00, creating a warm and welcoming space perfect for rest. Welcome to Red Roof Inn, where you’ll find a blend of comfort, value, and convenience in each stay.

A quiet retreat awaits guests at Red Roof Inn Florence Civic Center, with downtown Cypress Crossroads still within reach for a balanced stay of rest and adventure. Stay smart and enjoy Cypress Crossroads with a practical, comfortable hotel—book today!

  Call (855) 236-8982 to book with an agent.
  17.3 miles from Cypress Crossroads, SC 29069

Starting at

$69.00

per night

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TownePlace Suites by Marriott Florence

2650 Hospitality Boulevard Florence, SC

With rooms beginning at $204.99, TownePlace Suites by Marriott Florence provides budget-friendly comfort for travelers bound for Cypress Crossroads, creating a mellifluous and welcoming atmosphere. Appreciate the modern and stylish design of TownePlace Suites' accommodations, providing a pleasant and inviting atmosphere.

Rest in the tranquility of TownePlace Suites by Marriott Florence, with downtown Cypress Crossroads still accessible by car for a day of sightseeing or adventure. Take advantage of a Cypress Crossroads hotel that combines quality with cost-effective rates—secure now!

  Call (855) 234-2997 to book with an agent.
  17.4 miles from Cypress Crossroads, SC 29069

Starting at

$204.99

per night

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Fairfield Inn & Suites by Marriott Florence I-20

501 Woody Jones Boulevard Florence, SC

For a comfortable and inviting stay, Fairfield Inn & Suites by Marriott Florence I-20 offers budget-friendly rooms with rates from $179.99, creating a friendly environment ideal for travelers bound for Cypress Crossroads. Savor the moment with Fairfield's thoughtful touches, from freshly baked cookies in the lobby to personalized greetings upon check-in.

Unwind at Fairfield Inn & Suites by Marriott Florence I-20 in a quiet setting, where downtown Cypress Crossroads is still within easy reach for a day of adventure. Relax in Cypress Crossroads with a hotel that delivers convenience and savings—secure your room today!

  Call (855) 233-7850 to book with an agent.
  17.4 miles from Cypress Crossroads, SC 29069

Starting at

$179.99

per night

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Tru by Hilton Florence I-95

2140 West Lucas Street Florence, SC

At Tru by Hilton Florence I-95, travelers visiting Cypress Crossroads can enjoy inviting comfort with rooms beginning at $138.99, creating a warm and welcoming atmosphere ideal for rest. Experience the convenience of Tru by Hilton’s 24/7 market, offering snacks, light meals, and single-serve wine and beer options.

Relax in the calm surroundings of Tru by Hilton Florence I-95, knowing that the attractions of downtown Cypress Crossroads are just a smooth drive away. Step into Cypress Crossroads comfort with inviting, cost-effective lodging—book your room now!

  Call (855) 234-5074 to book with an agent.
  18.7 miles from Cypress Crossroads, SC 29069

Starting at

$138.99

per night

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