Top 24 Hotels In De Soto, Missouri 63020

Enjoy a warm and welcoming retreat at Holiday Inn Club Vacations Timber Creek Resort at De Soto an IHG Hotel as you explore De Soto, where inviting rooms offer relaxation, with rates beginning at just $199.00. Commit to a greener stay with Holiday Inn’s environmental initiatives, such as bulk dispensers and efficient energy practices.

From Holiday Inn Club Vacations Timber Creek Resort at De Soto an IHG Hotel, a short drive delivers guests into downtown De Soto, where they can explore the city’s top attractions and return to a restful stay. Enjoy a De Soto visit that’s both welcoming and lavish with premium accommodations—reserve now!

At Holiday Inn Express Hotel & Suites FESTUS SOUTH ST. LOUIS an IHG Hotel, travelers bound for De Soto will find budget-conscious comfort with rooms starting at $129.00, creating a clean, inviting space for relaxation. Experience the festive atmosphere during the holidays at Holiday Inn Express, with special decorations and seasonal offerings.

At Holiday Inn Express Hotel & Suites FESTUS SOUTH ST. LOUIS an IHG Hotel, guests can appreciate the relaxing environment, while downtown De Soto remains a short drive away for all their city adventures. Stay smart and relaxed in De Soto with value-driven amenities—book your room now!

Guests traveling to De Soto will appreciate the inviting comfort at Comfort Inn Festus St. Louis South, where soft rooms start at $87.99, creating a welcoming space for rest. Check out swiftly and simply with our express service, designed to keep your departure as smooth as your stay.

At Comfort Inn Festus St. Louis South, visitors can enjoy the calm of staying outside the city center, while downtown De Soto remains within reach for easy exploration. Rest easy in De Soto with a hotel that prioritizes your relaxation and budget—book today!

Enjoy a quiet stay at Quality Inn Festus as you journey to De Soto, where inviting rooms provide quality and warmth, with nightly rates starting at just $0.00. Unwind in the comfort of Quality Inn's rooms, each outfitted with cozy bedding and thoughtful amenities for a restful sleep.

From Quality Inn Festus, guests can easily drive into downtown De Soto, where they can explore the city’s attractions before returning to a quiet stay. Relax in De Soto with a hotel that combines modern elegance and unbeatable rates—lock in today!

Guests traveling to De Soto will find budget-friendly comfort at La Quinta Inn & Suites by Wyndham Festus St. Louis South, with inviting rooms starting at $113.99, creating a soothing and welcoming space. Enjoy La Quinta's signature bright and cheerful design, creating an inviting atmosphere that brightens every stay.

From La Quinta Inn & Suites by Wyndham Festus St. Louis South, guests can take a short drive into downtown De Soto, where they can enjoy the city’s top spots before returning to a calm stay. Take comfort in knowing your De Soto trip will be relaxing and cost-effective—book today!

With rooms starting at $79.99, Super 8 by Wyndham Pevely provides inviting accommodations for travelers to De Soto, creating a warm, welcoming environment ideal for relaxation. Rest assured with Super 8’s commitment to cleanliness, providing sanitized environments and peace of mind during your stay.

For a restful getaway, Super 8 by Wyndham Pevely offers calm surroundings, while downtown De Soto remains accessible for a day of sightseeing. Stay budget-savvy and relaxed on your De Soto adventure—lock in your hotel today!

With budget-friendly rooms starting at $52.99, Super 8 by Wyndham Bonne Terre provides practical accommodations for travelers bound for De Soto, creating a warm and inviting atmosphere. Relax or catch up on work in Super 8’s welcoming lobbies, designed to be versatile spaces for guests’ varied needs.

The serene atmosphere at Super 8 by Wyndham Bonne Terre provides a quiet retreat, with downtown De Soto just a drive away for exploration and excitement. Stay relaxed and enjoy more of De Soto with budget-friendly comfort—reserve today!

Guests visiting De Soto can unwind at Motel 6 Bonne Terre MO, where affordable rooms start at $0.00, providing a warm, welcoming space perfect for relaxation. Trust in Motel 6 for a straightforward stay, where clear and honest communication ensures you know exactly what to expect.

Relax in the quiet environment of Motel 6 Bonne Terre MO, where guests can enjoy peaceful surroundings and downtown De Soto remains nearby. Stay relaxed and keep your budget intact while visiting De Soto—reserve now!

At Super 8 by Wyndham Potosi, guests traveling to De Soto can unwind in budget-conscious accommodations with rooms beginning at $53.99, creating a warm and inviting space. Trust Super 8 for consistent comfort and quality, with each location upholding a high standard of guest experience.

Unwind at Super 8 by Wyndham Potosi, where peaceful surroundings offer a relaxing stay and downtown De Soto remains nearby for city exploration. Make your De Soto stay relaxing and cost-effective—reserve your room today!

For an affordable stay, WoodSpring Suites St. Louis Arnold offers plush rooms with rates beginning at $85.99, creating a clean and comfortable space near De Soto. Relax with the quiet hours policy at WoodSpring Suites, ensuring all guests can enjoy a peaceful and undisturbed stay.

At WoodSpring Suites St. Louis Arnold, you can rest easy knowing De Soto is just a short drive away for whenever you’re ready to explore. Settle into De Soto with a hotel that offers comfort and value—secure your room now!

With affordable rooms beginning at $118.99, Crown Pointe Lodge Best Western Signature Collection provides inviting accommodations for guests visiting De Soto, creating a warm, comfortable space. Host your next event or meeting at Best Western, with flexible spaces and dedicated staff to make your gathering a success.

Relax at Crown Pointe Lodge Best Western Signature Collection, where guests can unwind in a tranquil setting while still being close to the excitement of De Soto. Make your De Soto adventure exceptional without breaking the bank—secure your room today!

For an affordable and comfortable stay, Best Western St. Louis Inn offers inviting rooms with rates starting at $71.99, creating a clean, welcoming environment for guests. Unwind in Best Western's beautifully designed outdoor spaces, ideal for enjoying the fresh air and scenic surroundings.

Relax at Best Western St. Louis Inn, where spacious rooms and proximity to De Soto create an inviting atmosphere for guests. Discover the joy of De Soto with a hotel that pairs convenience with affordability—lock in today!

For budget-savvy travelers visiting De Soto, Hampton Inn Farmington offers inviting rooms with rates starting at $168.99, creating a warm and welcoming environment. Feel refreshed in Hampton's newly renovated rooms, where contemporary design meets the comfort and reliability you expect.

Relax and recharge at Hampton Inn Farmington, a peaceful spot where you can rest comfortably and still explore De Soto's attractions. Make your De Soto journey relaxing and budget-smart with well-appointed lodging—secure today!

Guests visiting De Soto can enjoy inviting accommodations at Holiday Inn Express & Suites Farmington an IHG Hotel, with budget-friendly rooms starting at $199.00, creating a clean, welcoming environment. Indulge in the added convenience of Holiday Inn Express's express checkout service, allowing for a swift and easy departure process.

Discover relaxation at Holiday Inn Express & Suites Farmington an IHG Hotel, where quiet comfort meets the convenience of being close to De Soto's vibrant offerings. Choose a hotel in De Soto that gives you more for your money—reserve your stay now!

For a welcoming stay near De Soto, Super 8 by Wyndham Farmington offers budget-friendly accommodations with rates starting at $57.00, creating a warm and inviting atmosphere. Welcome to Super 8 by Wyndham, where affordable stays meet comfortable accommodations and friendly service.

Guests seeking a peaceful stay will love Super 8 by Wyndham Farmington, positioned conveniently for easy access to De Soto's attractions. Enjoy De Soto to the fullest with a hotel that prioritizes comfort and value—book now!

With rooms starting at $79.99, Super 8 by Wyndham Eureka / Six Flags Nearby is a comfortable choice for guests visiting De Soto, creating a warm and inviting space ideal for a peaceful stay. Navigate your travels with confidence, as Super 8's front desk is always ready to assist with directions and local tips.

Relax at Super 8 by Wyndham Eureka / Six Flags Nearby, where spacious rooms and proximity to De Soto create an inviting atmosphere for guests. Enjoy De Soto adventures with a cozy, budget-friendly stay—secure your room today!

With affordable rooms starting at $73.99, Americas Best Inn Eureka provides safe accommodations for travelers bound for De Soto, creating a clean, inviting space. Learn about our commitment to the environment, with eco-friendly practices implemented at many of our locations.

Stay at Americas Best Inn Eureka for a blend of relaxation and exploration, with calm lodgings close to De Soto for easy day trips. Embrace your De Soto adventure with lodging that keeps comfort within reach—reserve today!

With budget-friendly rooms from $54.00, Quality Inn Farmington provides calm accommodations for travelers bound for De Soto, creating a warm, welcoming space. Feel the warmth of Quality Inn's hospitality, with staff committed to providing a memorable and comfortable stay.

Relax in the quiet comfort of Quality Inn Farmington, while keeping De Soto's attractions within easy reach whenever you desire. Plan your De Soto adventure with ease, knowing your accommodations are perfect—book today!

For a restful stay near De Soto, Quality Inn Near Six Flags St. Louis offers budget-friendly accommodations with rooms starting at $118.99, creating a soft, welcoming atmosphere. Stay cool and comfortable with Quality Inn's climate-controlled rooms, ensuring a perfect environment regardless of the weather outside.

Stay at Quality Inn Near Six Flags St. Louis to enjoy a peaceful retreat, where you can relax and still explore the excitement of De Soto when you’re ready. Stay comfortably and affordably while exploring all that De Soto has to offer—secure your room now!

For budget-savvy travelers visiting De Soto, Hampton Inn & Suites St. Louis / South I-55 offers inviting rooms with rates starting at $134.99, creating a warm and welcoming environment. Relish the availability of complimentary hot tea and coffee in the lobby, serving as a warm welcome throughout the day.

Find your restful escape at Hampton Inn & Suites St. Louis / South I-55, where the calm of your stay is complemented by the convenience of De Soto. Enjoy a stress-free De Soto visit with a hotel that offers exceptional value—book today!

Guests bound for De Soto will find cushy comfort at Comfort Inn Near Six Flags St. Louis, with inviting rooms starting at $114.00, creating a warm and welcoming environment perfect for rest. Stay updated and connected with state-of-the-art facilities and complimentary Wi-Fi, keeping you in touch and on top of your game.

Relax and recharge at Comfort Inn Near Six Flags St. Louis, where restful accommodations are paired with easy access to De Soto's downtown fun. Enjoy extra features and affordability on your De Soto trip—reserve your hotel now!

At Fairfield Inn & Suites by Marriott St. Louis South, travelers to De Soto will find inviting comfort with rooms beginning at $149.99, creating a friendly and comfortable environment ideal for rest. Enjoy the simplicity and value of Fairfield by Marriott, where essential amenities are included to ensure a pleasant stay.

Unwind at Fairfield Inn & Suites by Marriott St. Louis South, a peaceful haven just a short drive from the vibrant life of De Soto. Plan your De Soto visit with a hotel that offers comfort without compromise—secure today!

Uncover a warm retreat at Holiday Inn St. Louis West Six Flags an IHG Hotel near De Soto, where inviting rooms provide quality and relaxation, with nightly rates starting from just $159.95. Accommodate everyone with ease at Holiday Inn, offering accessible rooms and facilities to ensure comfort for all guests.

Enjoy the serene environment of Holiday Inn St. Louis West Six Flags an IHG Hotel, where peaceful lodgings provide the perfect base for exploring De Soto. Discover a De Soto hotel that turns your stay into a memorable and affordable experience—book today!

With budget-friendly rooms beginning at $57.99, Baymont Inn&Suites by Wyndham Farmington MO is ideal for guests traveling to De Soto, creating a comfortable, welcoming space for rest. Welcome to Baymont by Wyndham, where warm hospitality and cozy accommodations meet to create a memorable stay.

Guests seeking tranquility will love Baymont Inn&Suites by Wyndham Farmington MO, a peaceful retreat that offers quick access to De Soto for easy exploration. Elevate your De Soto travels with budget-conscious, well-equipped lodging—lock in today!