Top 24 Hotels In Defiance, Missouri 63341

Enjoy the charm and warmth of TownePlace Suites by Marriott St. Louis Chesterfield when visiting Defiance, with comfortable accommodations crafted for relaxation, beginning at just $139.99 per night. Explore local attractions with ease, thanks to TownePlace Suites' convenient locations near popular sites and business districts.

Guests at TownePlace Suites by Marriott St. Louis Chesterfield will appreciate the balance of city access and a quieter, more peaceful environment, with downtown Defiance still within reach. Rest easy in Defiance knowing your accommodations deliver on quality and affordability—secure now!

At Holiday Inn Express St. Louis West OFallon an IHG Hotel, travelers to Defiance will find tucked away, budget-friendly rooms with rates starting at $134.00, creating a warm and inviting space for relaxation. Experience the local vibe with Holiday Inn Express's recommendations for the best dining and attractions nearby.

With a brief drive into downtown Defiance, guests at Holiday Inn Express St. Louis West OFallon an IHG Hotel can enjoy the best of both worlds: city exploration and a quiet retreat. Enjoy the convenience of well-situated, cost-effective lodging in Defiance—book today!

For those visiting Defiance, Sleep Inn & Suites OFallon MO Technology Drive offers enveloping accommodations with rates beginning at $92.99, creating a warm, welcoming atmosphere perfect for unwinding. Learn about Sleep Inn’s commitment to the environment, which includes using energy-efficient practices and sustainable resources in daily operations.

Guests at Sleep Inn & Suites OFallon MO Technology Drive will appreciate the balance of city access and peaceful surroundings, with downtown Defiance still accessible by car for easy exploration. Plan a stress-free Defiance visit with accommodations that fit your budget—reserve now!

Relax in style at Staybridge Suites OFallon Chesterfield an IHG Hotel as you visit Defiance, where comfortable rooms create a reassuring retreat, with budget-friendly rates starting at $139.00. Keep up with your fitness routine at Staybridge Suites' on-site gym, equipped with modern equipment for a comprehensive workout.

At Staybridge Suites OFallon Chesterfield an IHG Hotel, guests can relax in a serene setting, with downtown Defiance still within easy reach for a day of sightseeing. Experience a hotel in Defiance that ensures you’re well taken care of—book your room today!

Experience quality and comfort at Residence Inn by Marriott OFallon as you explore Defiance, where comfy accommodations provide a relaxing environment, with rates beginning at $139.99. Enjoy the convenience of on-site business centers at Residence Inn, fully equipped for your professional needs.

With Defiance a drive from Residence Inn by Marriott OFallon, guests can easily explore the city’s attractions and then retreat to the peace and quiet of the hotel. Make the most of Defiance with a hotel that provides unparalleled service and value—lock in today!

With budget-conscious rooms beginning at $90.99, Comfort Inn & Suites St. Louis Chesterfield provides intimate-feeling accommodations for travelers bound for Defiance, creating a warm environment. Choose Comfort Inn for family travel, with accommodations and amenities designed to make stays comfortable for guests of all ages.

Guests staying at Comfort Inn & Suites St. Louis Chesterfield will love the quiet setting of the hotel, while downtown Defiance is still within easy reach for all their city adventures. Savor your Defiance experience with accommodations designed for relaxation—book today!

Hilton Garden Inn St. Louis / OFallon MO offers a relaxing atmosphere for travelers to Defiance, with inviting rooms that provide a warm-hearted escape, with nightly rates starting from $137.80. Relax in Hilton Garden Inn's lounge areas, which are perfect for informal meetings or simply enjoying a quiet moment.

The relaxing surroundings at Hilton Garden Inn St. Louis / OFallon MO offer a restful retreat, with downtown Defiance a convenient drive away for easy access to the city’s best spots. Discover the best way to unwind in Defiance with well-appointed, budget-friendly lodging—secure now!

With quality and comfort, The Wildwood Hotel is a refined choice near Defiance, where inviting rooms offer relaxation, with nightly rates beginning at $234.00. Stay in rooms that provide a luxurious retreat with enhanced amenities and attentive service, perfect for relaxing after a busy day.

From The Wildwood Hotel, guests can easily drive into downtown Defiance, where they can explore the city’s top destinations and return to a serene stay afterward. Plan your ideal Defiance getaway with a hotel that turns relaxation into an art—reserve now!

For an affordable stay near Defiance, Holiday Inn Express & Suites St. Louis Chesterfield an IHG Hotel offers inviting rooms with rates starting at $144.00, creating a clean and welcoming space ideal for rest. Stay refreshed with Holiday Inn Express's indoor or outdoor swimming pools, providing a relaxing escape or a fun family activity.

Guests at Holiday Inn Express & Suites St. Louis Chesterfield an IHG Hotel will love the peaceful surroundings, with downtown Defiance just a short trip away for easy access to the city’s highlights. Discover a hotel that elevates your Defiance adventure while staying budget-friendly—reserve now!

Uncover the comfort of Courtyard by Marriott St. Louis Chesterfield as you journey to Defiance, where delightful accommodations offer quality and warmth, with inviting rates starting at $149.99. Explore your destination with Courtyard's complimentary bicycle lending program, an eco-friendly way to see the sights and stay active.

For travelers looking for relaxation, Courtyard by Marriott St. Louis Chesterfield provides quiet surroundings with downtown Defiance just a short drive away. Enjoy added perks and peace of mind during your Defiance stay—secure your hotel room now!

Relax in style at Hampton Inn & Suites St. Louis / Chesterfield on your trip to Defiance, where quality rooms offer a warm environment, with rates starting at an accessible $120.99. Check in effortlessly with Hampton's streamlined online process, ensuring you can bypass the front desk and head straight to your room.

A relaxing stay awaits at Hampton Inn & Suites St. Louis / Chesterfield, with the calm surroundings offering a peaceful retreat and downtown Defiance still accessible by car. Stay in Defiance with a hotel that adds a touch of refinement to your adventure—book today!

With budget-friendly rooms from $114.00, Comfort Inn Near Six Flags St. Louis provides plush accommodations for travelers bound for Defiance, creating a warm, welcoming space. Look forward to every visit with Comfort Inn, knowing you'll experience top-tier service and welcoming hospitality.

At Comfort Inn Near Six Flags St. Louis, visitors can enjoy peaceful surroundings, with downtown Defiance just a simple drive away for a day of adventure. Get ready to experience Defiance in style with affordable, well-appointed lodging—reserve now!

Experience a delightful retreat at Holiday Inn St. Louis West Six Flags an IHG Hotel as you explore Defiance, where restful accommodations await at a starting rate of $159.95 per night. Indulge in Holiday Inn's room service, offering the convenience of delicious meals delivered straight to your door.

From Holiday Inn St. Louis West Six Flags an IHG Hotel, guests can enjoy the scenic route into downtown Defiance, where they can explore the city’s highlights before returning to a serene stay. Experience Defiance like never before with well-rounded, budget-friendly accommodations—reserve now!

With budget-friendly rooms beginning at $118.99, Quality Inn Near Six Flags St. Louis is ideal for guests traveling to Defiance, creating a comfortable, welcoming space for rest. Step into Quality Inn, where value meets comfort, ensuring a satisfying stay for every guest.

Relax in the comfort of Quality Inn Near Six Flags St. Louis, where guests can enjoy a quiet stay with downtown Defiance still within an easy drive. Find out how relaxing Defiance can be with accommodations that fit your budget—secure now!

For an inviting and budget-friendly stay near Defiance, Americas Best Inn Eureka offers calm rooms with rates beginning at $73.99, creating a clean, welcoming space. Feel the warmth of our hospitality, with staff dedicated to making your stay as enjoyable and comfortable as possible.

Travelers seeking both relaxation and proximity will find Americas Best Inn Eureka ideal, with downtown Defiance still close enough for sightseeing. Choose a hotel that adds value to your Defiance experience—reserve your stay now!

Guests traveling to Defiance will appreciate the budget-friendly comfort at Super 8 by Wyndham Eureka / Six Flags Nearby, where delightful rooms start at $85.00, creating a clean, inviting space. Refresh your travel wardrobe with Super 8's convenient laundry facilities, perfect for long journeys or unexpected spills.

For those who prefer calm surroundings, Super 8 by Wyndham Eureka / Six Flags Nearby offers a tranquil retreat, while keeping downtown Defiance within easy reach. Stay comfortably and save on your Defiance adventure—lock in your room today!

Relax in the inviting surroundings of Residence Inn by Marriott St. Louis Chesterfield on your journey to Defiance, where quality rooms offer comfort and value, with starting rates at $199.99 per night. Book a suite at Residence Inn for a comfortable and relaxing stay, whether you're traveling for business or pleasure.

Guests can enjoy a serene stay at Residence Inn by Marriott St. Louis Chesterfield, knowing that downtown Defiance is just a comfortable drive away for easy access. Treat yourself to a comfortable Defiance visit with thoughtful amenities and great savings—secure now!

Stay comfortably at Hilton Garden Inn Chesterfield on your journey to Defiance, where charming accommodations and welcoming service create a restful retreat, all from $127.99. Mix and mingle at Hilton Garden Inn's social events, where evening receptions offer a chance to relax and meet other guests.

Rest easy at Hilton Garden Inn Chesterfield, enjoying quiet surroundings while still being within a convenient drive of downtown Defiance for exploration. Plan a Defiance getaway with accommodations that blend affordability with sophistication—reserve now!

Find a peaceful escape at AC Hotel by Marriott St. Louis Chesterfield on your trip to Defiance, where quality accommodations provide a warm atmosphere, with rates beginning at $179.99. Experience the sophisticated amenities at AC Hotels, ensuring every stay is luxurious, from high-speed Wi-Fi to plush bedding.

At AC Hotel by Marriott St. Louis Chesterfield, a relaxing stay is complemented by the nearby excitement of downtown Defiance, accessible by a short drive. Find out how luxurious Defiance can be with a hotel that takes relaxation seriously—lock in today!

Discover tranquility at DoubleTree by Hilton Hotel St. Louis Chesterfield near Defiance, where quality rooms offer relaxation and luxury, with nightly rates beginning at an affordable $126.07. Drift into dreams on DoubleTree by Hilton's Sweet Dreams® beds, crafted for a perfect night's sleep.

For those seeking tranquility, DoubleTree by Hilton Hotel St. Louis Chesterfield provides a serene retreat while keeping downtown Defiance within reach for sightseeing. Get ready for a Defiance trip where every moment feels perfectly curated—lock in today!

For an affordable and inviting stay, Best Western Plus Washington Hotel offers restful rooms with rates from $163.99, creating a clean, comfortable atmosphere perfect for travelers. Experience the boutique charm of Best Western Plus, where each hotel's décor and ambiance are uniquely tailored to reflect its location.

Unwind in the serene surroundings of Best Western Plus Washington Hotel, where quiet surroundings provide a restful stay and downtown Defiance remains close by. Enjoy your Defiance visit with a hotel that delivers maximum comfort for less—secure now!

Find the perfect balance of comfort and value at Hyatt Place St. Louis / Chesterfield as you explore Defiance, where inviting accommodations begin at an accessible $149.00 per night. Stay connected with free Wi-Fi at Hyatt Place, ensuring you're always just a click away from what matters most.

Experience a serene retreat at Hyatt Place St. Louis / Chesterfield, where quiet surroundings offer relaxation and downtown Defiance is just a drive away. Explore Defiance while enjoying a hotel that makes comfort and value a priority—secure now!

Guests bound for Defiance will find affordable, tucked away comfort at Super 8 by Wyndham OFallon MO / St. Louis Area, with rates starting at $85.00, providing a clean and welcoming atmosphere for relaxation. Rely on Super 8 for a consistent and pleasant stay, where guest comfort and satisfaction are the top priorities.

For a peaceful retreat, Super 8 by Wyndham OFallon MO / St. Louis Area offers calm surroundings with the added bonus of downtown Defiance still being nearby. Stay comfortably and on budget while visiting Defiance—lock in your stay today!

Unwind in style at Hampton Inn St. Louis / Chesterfield as you visit Defiance, where quality accommodations create a relaxing environment, with rates beginning at $123.99. Experience the attention to detail in Hampton’s housekeeping service, ensuring your room is spotless and well-maintained throughout your stay.

At Hampton Inn St. Louis / Chesterfield, visitors can unwind in peaceful surroundings, while downtown Defiance remains a convenient drive away for a day of city adventures. Enjoy a memorable Defiance visit with accommodations that offer premium comfort and value—reserve your room now!