The best deals on hotels when visiting Great Branch in South Carolina.

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Top 24 Hotels In Great Branch, South Carolina 29115

Orangeburg Inn & Suites

1415 John C Calhoun Dr Orangeburg, SC

At Orangeburg Inn & Suites, guests traveling to Great Branch will find affordable comfort with rooms beginning at $60.99, creating a warm and welcoming atmosphere perfect for unwinding. Stay in a room that delivers practical comfort, with amenities designed to make your visit both pleasant and affordable.

From Orangeburg Inn & Suites, guests can take advantage of easy access to downtown Great Branch, while enjoying a more spacious and quiet retreat at the hotel. Plan ahead and stay affordably while exploring Great Branch—reserve your hotel now!

  Call (855) 234-7135 to book with an agent.
  5.4 miles from Great Branch, SC 29115

Starting at

$60.99

per night

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Suburban Studios

3671 Saint Matthews Road Orangeburg, SC

For a enchanting and affordable stay near Great Branch, Suburban Studios offers budget-friendly rooms with rates from $75.99, creating a warm and welcoming atmosphere. Enjoy a setting that blends affordability with comfort, where each room is equipped with everything needed for a restful stay.

From Suburban Studios, a quick trip into downtown Great Branch offers guests the chance to explore the city’s top spots while enjoying the tranquility of the hotel. Choose affordability and extra perks for your Great Branch travels—book your hotel now!

  Call (855) 235-6136 to book with an agent.
  8.0 miles from Great Branch, SC 29115

Starting at

$75.99

per night

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Baymont by Wyndham Orangeburg North

3583 Saint Matthews Rd Orangeburg, SC

Guests visiting Great Branch will find snug comfort at Baymont by Wyndham Orangeburg North, where budget-friendly rooms start at $96.99, creating a warm and inviting space perfect for relaxation. Enjoy the simplicity and value of Baymont by Wyndham, offering comfortable accommodations without unnecessary frills.

At Baymont by Wyndham Orangeburg North, guests can enjoy the balance of being near the city’s highlights, while staying in a quieter, more serene environment. Escape to Great Branch with budget-wise lodging that offers more—book your stay now!

  Call (855) 235-6136 to book with an agent.
  8.0 miles from Great Branch, SC 29115

Starting at

$96.99

per night

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Super 8 by Wyndham Orangeburg

3608 Saint Matthews Rd Orangeburg, SC

For those traveling to Great Branch, Super 8 by Wyndham Orangeburg offers inviting, budget-friendly comfort with rooms from $80.00, creating a clean and welcoming space ideal for rest. Entertain yourself with Super 8’s diverse TV and streaming options, available in each room for a personalized viewing experience.

With a brief drive into downtown Great Branch, guests at Super 8 by Wyndham Orangeburg can explore the city’s top spots while retreating to a peaceful environment afterward. Book an inviting hotel that won’t break the bank for your Great Branch visit—secure today!

  Call (855) 234-5074 to book with an agent.
  8.1 miles from Great Branch, SC 29115

Starting at

$80.00

per night

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Quality Inn & Suites

3671 Saint Matthews Rd Orangeburg, SC

For budget-savvy travelers visiting Great Branch, Quality Inn & Suites offers inviting rooms with rates starting at $113.99, creating a warm and welcoming environment. Stay engaged with Quality Inn's community events, including local market days and cultural festivals recommended by the hotel.

Guests staying at Quality Inn & Suites will enjoy a peaceful retreat, with downtown Great Branch just a drive away for easy access to all the city’s attractions. Step into a welcoming Great Branch stay with accommodations that blend comfort and affordability—reserve now!

  Call (855) 236-8982 to book with an agent.
  8.1 miles from Great Branch, SC 29115

Starting at

$113.99

per night

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Travelodge by Wyndham Orangeburg

3620 Saint Matthews Rd Orangeburg, SC

Guests traveling to Great Branch will appreciate the budget-friendly comfort at Travelodge by Wyndham Orangeburg, where cushy rooms start at $94.05, creating a clean, inviting space. Savor the convenience of on-site dining options at select Travelodge locations, serving delicious meals throughout the day.

At Travelodge by Wyndham Orangeburg, visitors can enjoy the calm atmosphere of the hotel, while downtown Great Branch remains easily accessible for a day of adventure. Enjoy added perks at a great rate for your Great Branch trip—book your hotel room now!

  Call (855) 235-6136 to book with an agent.
  8.1 miles from Great Branch, SC 29115

Starting at

$94.05

per night

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Days Inn by Wyndham Orangeburg

3691 Saint Matthews Rd Orangeburg, SC

At Days Inn by Wyndham Orangeburg, travelers to Great Branch can enjoy reassuring, affordable rooms with rates beginning at $93.99, creating a welcoming and relaxing environment. Take a refreshing dip in our available swimming pools, a perfect spot to relax and unwind no matter the time of year.

With downtown Great Branch a convenient drive away, guests at Days Inn by Wyndham Orangeburg can explore the city’s top destinations while enjoying the serenity of the hotel afterward. Book now and make your Great Branch trip comfortable and cost-effective—secure today!

  Call (855) 234-5074 to book with an agent.
  8.1 miles from Great Branch, SC 29115

Starting at

$93.99

per night

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Sleep Inn Orangeburg

3689 Saint Matthews Rd Orangeburg, SC

For a tranquil and inviting stay, Sleep Inn Orangeburg offers budget-friendly accommodations with rates from $130.99, creating a warm and comfortable environment. Engage with the community and local culture through Sleep Inn's partnership with area attractions and events, offering guests unique experiences.

At Sleep Inn Orangeburg, guests can appreciate the balance of being far enough for quiet, while still close enough to downtown Great Branch for a day of sightseeing. Relax in a hotel that makes your Great Branch adventure feel special and stress-free—reserve now!

  Call (855) 235-6136 to book with an agent.
  8.2 miles from Great Branch, SC 29115

Starting at

$130.99

per night

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Holiday Inn Express & Suites Orangeburg

118 Sleep Inn Road Orangeburg, SC

With rooms beginning at $154.00, Holiday Inn Express & Suites Orangeburg provides budget-friendly comfort for travelers bound for Great Branch, creating a warm and welcoming atmosphere. Make the most of Holiday Inn Express's express breakfast options, offering quick and tasty meals for guests on the move.

Guests staying at Holiday Inn Express & Suites Orangeburg will appreciate the balance of easy city access and the calm of a quieter setting further from downtown Great Branch. Enjoy Great Branch to the fullest with accommodations that won’t strain your wallet—reserve today!

  Call (855) 234-2997 to book with an agent.
  8.2 miles from Great Branch, SC 29115

Starting at

$154.00

per night

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Tru by Hilton Orangeburg

739 Citadel Road Orangeburg, SC

With rooms from $158.99, Tru by Hilton Orangeburg provides affordable comfort for guests visiting Great Branch, creating a clean and gentle environment ideal for relaxation. Enjoy the efficiency of Tru by Hilton’s self-service kiosks, allowing for quick check-in, check-out, and guest service requests.

With downtown Great Branch just a drive away, guests at Tru by Hilton Orangeburg can explore the city’s highlights and return to the hotel’s calm, serene environment. Find comfort and value in Great Branch with a hotel that delivers on both fronts—reserve now!

  Call (855) 233-0132 to book with an agent.
  8.3 miles from Great Branch, SC 29115

Starting at

$158.99

per night

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SpringHill Suites by Marriott Orangeburg

675 Citadel Rd Orangeburg, SC

For a soothing and restful stay, SpringHill Suites by Marriott Orangeburg offers inviting accommodations with rates beginning at $179.99, creating a warm, comfortable environment. Earn and redeem points with the Marriott Bonvoy™ program during your stay at SpringHill Suites.

Guests staying at SpringHill Suites by Marriott Orangeburg will enjoy the quiet atmosphere, while downtown Great Branch is still just a drive away for a day of sightseeing and adventure. Experience Great Branch in comfort and style without overspending—lock in your room now!

  Call (855) 239-4019 to book with an agent.
  8.4 miles from Great Branch, SC 29115

Starting at

$179.99

per night

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Comfort Inn & Suites

746 Citadel Rd Orangeburg, SC

At Comfort Inn & Suites, travelers headed to Great Branch will find inviting accommodations with rooms starting at $171.99, creating a clean and comfortable space. Relax in Comfort Inn's soft, premium bedding, designed to ensure a restful night's sleep for every guest.

From Comfort Inn & Suites, a brief drive into downtown Great Branch offers guests the chance to experience the city’s top spots before returning to a restful stay. Plan your Great Branch trip with confidence, knowing your hotel delivers comfort and value—lock in today!

  Call (855) 233-0132 to book with an agent.
  8.8 miles from Great Branch, SC 29115

Starting at

$171.99

per night

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Fairfield Inn by Marriott Orangeburg

663 Citadel Road Orangeburg, SC

For a budget-friendly and cozy-like stay, Fairfield Inn by Marriott Orangeburg offers inviting rooms with rates from $199.99, creating a warm and comfortable environment near Great Branch. Enjoy the practicality and convenience of Fairfield's in-room amenities, designed to enhance both short and extended stays.

The drive into downtown Great Branch from Fairfield Inn by Marriott Orangeburg is convenient, offering guests easy access to the city’s top attractions without the noise. Enjoy a hassle-free Great Branch visit with accommodations that prioritize value—reserve today!

  Call (855) 234-5074 to book with an agent.
  8.9 miles from Great Branch, SC 29115

Starting at

$199.99

per night

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Days Inn by Wyndham Orangeburg South

3402 Five Chop Rd Orangeburg, SC

With budget-conscious rooms starting at $88.99, Days Inn by Wyndham Orangeburg South provides affordable comfort for guests visiting Great Branch, creating a clean and enchanting environment for rest. Experience the inviting ambience of our breakfast areas, where you can enjoy good food in good company.

Relax in the serene environment at Days Inn by Wyndham Orangeburg South, with the vibrant energy of downtown Great Branch still within reach for a day trip. Enjoy a stress-free Great Branch trip with affordable, comfortable accommodations—lock in now!

  Call (855) 233-7850 to book with an agent.
  13.7 miles from Great Branch, SC 29115

Starting at

$88.99

per night

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Comfort Inn & Suites Santee

221 Britain St Santee, SC

With rates beginning at $135.99, Comfort Inn & Suites Santee is an ideal choice for budget-savvy travelers to Great Branch, creating a warm and inviting space. Explore local culture and attractions with Comfort Inn as your base, conveniently located to help you discover the best of each destination.

Settle into comfort at Comfort Inn & Suites Santee, where guests can recharge in a serene setting with the energy of Great Branch a short drive away. Choose a hotel that enhances your Great Branch experience with thoughtful amenities—book today!

  Call (855) 233-7850 to book with an agent.
  27.7 miles from Great Branch, SC 29115

Starting at

$135.99

per night

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Peach Tree Inn

111 Conners Dr St. George, SC

With rates from $60.99, Peach Tree Inn is ideal for travelers bound for Great Branch, providing harmonious, budget-friendly accommodations perfect for relaxation. Enjoy the added comfort and convenience of rooms that provide a little extra, making your stay both enjoyable and affordable.

Relax at Peach Tree Inn, where restful lodgings are matched with the convenience of having Great Branch's highlights nearby. Enjoy more of Great Branch with a practical hotel designed for your convenience—reserve now!

  Call (855) 233-0132 to book with an agent.
  27.7 miles from Great Branch, SC 29115

Starting at

$60.99

per night

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Holiday Inn Santee an IHG Hotel

139 Bradford Blvd Santee, SC

At Holiday Inn Santee an IHG Hotel, enjoy a comfortable stay near Great Branch, with inviting rooms providing a restful experience from $155.00 per night. Adjust your room’s climate with ease using Holiday Inn’s in-room temperature controls, ensuring comfort no matter the weather outside.

Enjoy a quiet stay at Holiday Inn Santee an IHG Hotel, where guests can recharge and still visit Great Branch's lively attractions just a short drive away. Experience the beauty of Great Branch with a hotel that makes travel simple and enjoyable—lock in today!

  Call (855) 234-7135 to book with an agent.
  27.7 miles from Great Branch, SC 29115

Starting at

$155.00

per night

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Quality Inn & Suites

8929 Old Number Six Highway Santee, SC

At Quality Inn & Suites, guests bound for Great Branch can enjoy affordable accommodations with rooms beginning at $75.99, creating a warm, inviting atmosphere for relaxation. Relax with Quality Inn's personalized streaming services, allowing you to access your favorite content directly in your room.

Escape to Quality Inn & Suites for a refreshing stay, and enjoy being just a drive away from the excitement of Great Branch. Explore Great Branch with a hotel that makes comfort and savings a top priority—book today!

  Call (855) 233-7850 to book with an agent.
  27.8 miles from Great Branch, SC 29115

Starting at

$75.99

per night

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Baymont by Wyndham Santee

249 Britain Street Santee, SC

For an affordable stay, Baymont by Wyndham Santee offers soothing rooms with rates beginning at $92.99, creating a clean and comfortable space near Great Branch. Enjoy a relaxing evening in Baymont by Wyndham’s bar and lounge areas, perfect for socializing or enjoying a quiet drink.

Guests at Baymont by Wyndham Santee can enjoy the serene surroundings while knowing the best of Great Branch is just a drive away. Enjoy the convenience of well-situated, cost-effective lodging in Great Branch—book today!

  Call (855) 234-7135 to book with an agent.
  27.8 miles from Great Branch, SC 29115

Starting at

$92.99

per night

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Red Roof Inn Santee

9091 Old Highway 6 Santee, SC

At Red Roof Inn Santee, travelers to Great Branch can enjoy inviting accommodations with rooms starting at $81.99, creating a warm, welcoming space ideal for relaxation. Discover convenient in-room amenities like coffee makers and hairdryers at Red Roof Inn, designed to make your stay as comfortable as possible.

Escape to the comfort of Red Roof Inn Santee, a tranquil spot where guests can relax and still explore Great Branch with ease. Stay comfortably and affordably for your Great Branch adventure—book your room today!

  Call (855) 234-7135 to book with an agent.
  27.8 miles from Great Branch, SC 29115

Starting at

$81.99

per night

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Tru by Hilton Santee

263 Britain St. & 273 Britain St. Santee, SC

For a comfortable and inviting stay, Tru by Hilton Santee offers secure rooms with rates beginning at $154.99, creating a clean and comfortable space near Great Branch. Relax in the media rooms at Tru by Hilton, where guests can watch movies, play video games, or catch up on television shows.

Unwind in comfort at Tru by Hilton Santee, where guests are treated to peaceful surroundings with Great Branch's highlights just a short trip away. Make Great Branch travel feel effortless with a cost-effective, welcoming hotel—book now!

  Call (855) 235-0725 to book with an agent.
  27.8 miles from Great Branch, SC 29115

Starting at

$154.99

per night

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Best Western Plus Santee Inn

I 95 Exit 98 Santee, SC

With budget-friendly rooms beginning at $125.99, Best Western Plus Santee Inn is ideal for guests traveling to Great Branch, creating a comfortable, welcoming space for rest. Enjoy a special evening with themed dinner nights at Best Western Plus, offering a range of culinary experiences.

Discover the balance of rest and adventure at Best Western Plus Santee Inn, where you can relax in peace and explore Great Branch whenever you choose. Enjoy Great Branch to the fullest with accommodations that keep your wallet happy—reserve now!

  Call (855) 234-7135 to book with an agent.
  28.2 miles from Great Branch, SC 29115

Starting at

$125.99

per night

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Hampton Inn Santee I-95

9060 Old Number Six Hwy Santee, SC

With budget-friendly rooms starting at $152.99, Hampton Inn Santee I-95 is ideal for travelers bound for Great Branch, providing a warm and inviting environment for relaxation. Kickstart your day with a premium coffee from Hampton’s select coffee brands, ensuring a high-quality brew to wake you up right.

Step away from the fast pace of life and enjoy the serene atmosphere of Hampton Inn Santee I-95, with Great Branch always close enough for a visit. Relax in Great Branch with a hotel that delivers convenience and savings—secure your room today!

  Call (855) 239-4019 to book with an agent.
  28.2 miles from Great Branch, SC 29115

Starting at

$152.99

per night

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Fairfield Inn & Suites by Marriott Santee

9074 Old Number Six Hwy Santee, SC

Guests traveling to Great Branch will appreciate the gentle comfort at Fairfield Inn & Suites by Marriott Santee, where budget-friendly rooms start at $159.99, creating a warm and inviting space for rest. Enjoy the modern conveniences of Fairfield's guest rooms, including mini-fridges and microwaves for snacks and light meals.

Step away from the crowds at Fairfield Inn & Suites by Marriott Santee, a quiet escape where Great Branch's vibrant offerings are never too far from reach. Relax and rejuvenate in Great Branch with accommodations that fit your budget perfectly—lock in today!

  Call (855) 235-0725 to book with an agent.
  28.2 miles from Great Branch, SC 29115

Starting at

$159.99

per night

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