The best deals on hotels when visiting Jernigan Crossroads in South Carolina.

From game day to getaway, save even more on every hotel stay.

Save up to 70% when booking as a group. Select 9+ rooms to get started.

Top 24 Hotels In Jernigan Crossroads, South Carolina 29532

Super 8 by Wyndham Florence SC I-95 North / Hwy 76

3783A West Palmetto Street Florence, SC

With rooms beginning at $50.99, Super 8 by Wyndham Florence SC I-95 North / Hwy 76 is a convenient choice for travelers to Jernigan Crossroads, providing budget-conscious comfort in a warm, inviting setting. Enjoy a rejuvenated setting in Super 8's updated rooms, offering a fresh and inviting atmosphere for every guest.

Guests staying at Super 8 by Wyndham Florence SC I-95 North / Hwy 76 will appreciate how easy it is to drive into downtown Jernigan Crossroads, where the city’s top attractions are just a short trip away. Make the most of your Jernigan Crossroads trip with cost-saving, inviting lodging—secure today!

  Call (855) 236-8982 to book with an agent.
  5.6 miles from Jernigan Crossroads, SC 29532

Starting at

$50.99

per night

Read Reviews View Amenities View All Rooms

Homewood Suites by Hilton Florence

3450 West Radio Drive Florence, SC

Homewood Suites by Hilton Florence offers a warm retreat for travelers to Jernigan Crossroads, with comfortable rooms designed to create a welcoming environment, with room rates starting at $156.99. Stay entertained with Homewood Suites' in-suite HDTVs and premium cable channels, perfect for a movie night in.

From Homewood Suites by Hilton Florence, a brief drive takes guests into downtown Jernigan Crossroads, where they can experience the city’s highlights and return to a peaceful stay afterward. Enjoy your Jernigan Crossroads trip with a hotel that blends modern design with budget-friendly rates—secure now!

  Call (855) 235-0725 to book with an agent.
  5.9 miles from Jernigan Crossroads, SC 29532

Starting at

$156.99

per night

Read Reviews View Amenities View All Rooms

Staybridge Suites Florence Civic Center an IHG Hotel

150 Westpark Drive Florence, SC

Relax in the inviting ambiance of Staybridge Suites Florence Civic Center an IHG Hotel as you journey to Jernigan Crossroads, where quality rooms offer comfort, with budget-friendly rates from $191.96. Enjoy the privacy and convenience of Staybridge Suites' en-suite bathrooms, featuring modern fixtures and amenities.

Guests staying at Staybridge Suites Florence Civic Center an IHG Hotel can enjoy the calm of being further from the city, with downtown Jernigan Crossroads still accessible by car for a day of exploration. Step into a Jernigan Crossroads stay that blends convenience with superior comfort—lock in your room today!

  Call (855) 235-6136 to book with an agent.
  6.0 miles from Jernigan Crossroads, SC 29532

Starting at

$191.96

per night

Read Reviews View Amenities View All Rooms

Holiday Inn Express & Suites Florence I-95 & I-20 Civic Center an IHG Hotel

3440 West Radio Dr Florence, SC

At Holiday Inn Express & Suites Florence I-95 & I-20 Civic Center an IHG Hotel, guests traveling to Jernigan Crossroads will find inviting accommodations with rooms starting at $144.00, creating a gentle, welcoming environment perfect for rest. Indulge in the comfort of Holiday Inn Express's plush duvet covers and soft linens, ensuring a cozy and restful sleep experience.

Guests at Holiday Inn Express & Suites Florence I-95 & I-20 Civic Center an IHG Hotel can enjoy the quiet surroundings, knowing that downtown Jernigan Crossroads is still just a drive away for all their sightseeing needs. Enjoy your Jernigan Crossroads journey with a hotel that keeps you comfy and on budget—reserve today!

  Call (855) 239-4019 to book with an agent.
  6.0 miles from Jernigan Crossroads, SC 29532

Starting at

$144.00

per night

Read Reviews View Amenities View All Rooms

Quality Inn&Suites Civic

150 Dunbarton Dr Florence, SC

With rates beginning at $95.99, Quality Inn&Suites Civic provides inviting accommodations for travelers visiting Jernigan Crossroads, creating a quiet, welcoming space for relaxation. Stay seamlessly connected with Quality Inn's complimentary high-speed Wi-Fi, ensuring you're always in touch and entertained.

At Quality Inn&Suites Civic, guests can enjoy a peaceful, spacious stay while still being close enough to downtown Jernigan Crossroads for a day of exploring. Find a hotel in Jernigan Crossroads that checks all the boxes for a great stay—book today!

  Call (855) 233-7850 to book with an agent.
  6.2 miles from Jernigan Crossroads, SC 29532

Starting at

$95.99

per night

Read Reviews View Amenities View All Rooms

Days Inn by Wyndham Florence Near Civic Center

140 Dunbarton Dr Florence, SC

Guests bound for Jernigan Crossroads will find relaxing accommodations at Days Inn by Wyndham Florence Near Civic Center, with rooms starting at $78.99, creating a clean and welcoming space perfect for relaxation. Relax with a peace of mind provided by our round-the-clock security measures, ensuring a safe environment for all guests.

A short drive from Days Inn by Wyndham Florence Near Civic Center takes guests into downtown Jernigan Crossroads, where they can experience the city’s highlights before retreating to a quiet stay. Plan your Jernigan Crossroads visit with accommodations that make relaxation affordable—book today!

  Call (855) 235-6136 to book with an agent.
  6.3 miles from Jernigan Crossroads, SC 29532

Starting at

$78.99

per night

Read Reviews View Amenities View All Rooms

Home2 Suites by Hilton Florence SC

900 Woody Jones Blvd Florence, SC

Experience the comfort of Home2 Suites by Hilton Florence SC as you explore Jernigan Crossroads, where inviting rooms create a peaceful retreat, with budget-friendly rates from $138.99 per night. Enjoy peace of mind with state-of-the-art security systems, including surveillance cameras and secure key card access to all areas.

A short drive from Home2 Suites by Hilton Florence SC brings guests to downtown Jernigan Crossroads, where they can explore the city’s most popular destinations and attractions. Find out how enjoyable Jernigan Crossroads can be with thoughtfully designed, affordable lodging—book today!

  Call (855) 235-6136 to book with an agent.
  6.3 miles from Jernigan Crossroads, SC 29532

Starting at

$138.99

per night

Read Reviews View Amenities View All Rooms

Aloft Florence

820 WOODY JONES BOULEVARD Florence, SC

Choose Aloft Florence for a comfortable stay when visiting Jernigan Crossroads, where quality rooms offer relaxation, with affordable rates beginning at $154.99. Trust in Aloft's enhanced cleaning and safety measures, which ensure a safe and stress-free environment for all guests.

At Aloft Florence, guests can enjoy the comfort of being slightly removed from the city’s busiest areas, with downtown Jernigan Crossroads just a convenient drive away. Enjoy a Jernigan Crossroads stay where your comfort is always the top priority—book your accommodations today!

  Call (855) 234-5074 to book with an agent.
  6.4 miles from Jernigan Crossroads, SC 29532

Starting at

$154.99

per night

Read Reviews View Amenities View All Rooms

Comfort Inn & Suites

527 Woody Jones Blvd Florence, SC

At Comfort Inn & Suites, travelers visiting Jernigan Crossroads can enjoy inviting accommodations with rooms starting at $128.99, creating a warm, welcoming environment for rest. Trust in the attentive and caring staff at Comfort Inn, ready to ensure your stay is both comfortable and enjoyable.

A brief drive from Comfort Inn & Suites brings guests into downtown Jernigan Crossroads, making it simple to explore the city’s top destinations and then unwind at the hotel. Get ready for a memorable Jernigan Crossroads trip with lodging that puts you first—secure now!

  Call (855) 234-7135 to book with an agent.
  6.4 miles from Jernigan Crossroads, SC 29532

Starting at

$128.99

per night

Read Reviews View Amenities View All Rooms

Hampton Inn & Suites Florence Center

3000 West Radio Dr Florence, SC

At Hampton Inn & Suites Florence Center, travelers headed to Jernigan Crossroads will find inviting accommodations with rooms starting at $151.99, creating a clean and comfortable space. Recharge with Hampton's On the Run™ breakfast bags, available Monday through Friday for a healthy meal on the go.

Guests at Hampton Inn & Suites Florence Center can enjoy the quiet retreat of the hotel, while still having easy access to downtown Jernigan Crossroads for sightseeing and exploration. Get ready for a Jernigan Crossroads visit with a hotel that makes relaxation effortless—lock in today!

  Call (855) 234-2997 to book with an agent.
  6.4 miles from Jernigan Crossroads, SC 29532

Starting at

$151.99

per night

Read Reviews View Amenities View All Rooms

Residence Inn Marriott Florence

2660 Hospitality Blvd Florence, SC

Stay at Residence Inn Marriott Florence for a relaxing visit to Jernigan Crossroads, where quality accommodations create a warm experience, with budget-friendly rates from $214.99 per night. Relax in the inviting lobby areas of Residence Inn, where you can meet other guests or simply enjoy some quiet time.

With downtown Jernigan Crossroads still within easy reach, guests at Residence Inn Marriott Florence can explore the city’s highlights while enjoying the hotel’s tranquil setting. Relax and rejuvenate in Jernigan Crossroads with a hotel that makes you feel right at home—secure now!

  Call (855) 239-4019 to book with an agent.
  6.5 miles from Jernigan Crossroads, SC 29532

Starting at

$214.99

per night

Read Reviews View Amenities View All Rooms

Hilton Garden Inn Florence

2671 Hospitality Boulevard Florence, SC

Guests bound for Jernigan Crossroads will enjoy budget-conscious comfort at Hilton Garden Inn Florence, with rooms starting at $125.99, creating a warm and inviting atmosphere. Trust in Hilton Garden Inn's commitment to satisfaction, with staff dedicated to resolving any issues promptly and efficiently.

Guests staying at Hilton Garden Inn Florence will enjoy the quiet surroundings, while downtown Jernigan Crossroads is still within reach for a day of exploration. Enjoy Jernigan Crossroads with an affordable hotel that enhances your travel experience—secure now!

  Call (855) 234-2997 to book with an agent.
  6.5 miles from Jernigan Crossroads, SC 29532

Starting at

$125.99

per night

Read Reviews View Amenities View All Rooms

SpringHill Suites by Marriott Florence

2670 Hospitality Blvd Florence, SC

Stay comfortably at SpringHill Suites by Marriott Florence as you explore Jernigan Crossroads, where inviting rooms provide relaxation and quality, with room rates beginning at just $152.99. Join the Marriott Bonvoy™ loyalty program at SpringHill Suites, earning points toward free nights, travel experiences, and more.

With downtown Jernigan Crossroads still within reach by car, guests at SpringHill Suites by Marriott Florence can enjoy the city’s highlights while benefiting from a more relaxed, quieter stay. Enjoy added perks and comfort while exploring Jernigan Crossroads—secure your accommodations now!

  Call (855) 234-2997 to book with an agent.
  6.5 miles from Jernigan Crossroads, SC 29532

Starting at

$152.99

per night

Read Reviews View Amenities View All Rooms

Courtyard by Marriott Florence

2680 Hospitality Blvd Florence, SC

Choose Courtyard by Marriott Florence for a comfortable stay near Jernigan Crossroads, where inviting rooms create a relaxing environment, with room rates starting at $149.99 per night. Experience the luxury of Courtyard's rainfall showers, offering a spa-like experience in the comfort of your own room.

At Courtyard by Marriott Florence, guests can unwind in a peaceful environment, while downtown Jernigan Crossroads is still within easy reach for a day’s adventures. Take a break from the ordinary in Jernigan Crossroads with a hotel that makes relaxation easy—book today!

  Call (855) 235-6136 to book with an agent.
  6.5 miles from Jernigan Crossroads, SC 29532

Starting at

$149.99

per night

Read Reviews View Amenities View All Rooms

Red Roof Inn Florence Civic Center

2690 David H McLeod Boulevard Florence, SC

Guests visiting Jernigan Crossroads will enjoy the budget-friendly accommodations at Red Roof Inn Florence Civic Center, where safe rooms start at $69.00, creating a warm and inviting space. Experience great value and cleanliness at Red Roof Inn, where affordable rates are matched by well-maintained and tidy accommodations.

At Red Roof Inn Florence Civic Center, guests can unwind in a serene environment while having downtown Jernigan Crossroads just a drive away for easy city access. Enjoy Jernigan Crossroads with added comfort and great rates—book your room now!

  Call (855) 233-7850 to book with an agent.
  6.6 miles from Jernigan Crossroads, SC 29532

Starting at

$69.00

per night

Read Reviews View Amenities View All Rooms

TownePlace Suites by Marriott Florence

2650 Hospitality Boulevard Florence, SC

Guests visiting Jernigan Crossroads will find inviting comfort at TownePlace Suites by Marriott Florence, where enveloping rooms start at $224.99, creating a welcoming space perfect for relaxation. Outdoor exercise spaces and pools at TownePlace Suites cater to guests with active lifestyles.

With a brief drive into downtown Jernigan Crossroads, guests at TownePlace Suites by Marriott Florence can balance city exploration with the relaxing atmosphere of the hotel. Stay affordably in Jernigan Crossroads with a hotel that enhances your travel experience—reserve now!

  Call (855) 235-0725 to book with an agent.
  6.7 miles from Jernigan Crossroads, SC 29532

Starting at

$224.99

per night

Read Reviews View Amenities View All Rooms

Fairfield Inn & Suites by Marriott Florence I-20

501 Woody Jones Boulevard Florence, SC

Guests bound for Jernigan Crossroads can enjoy inviting comfort at Fairfield Inn & Suites by Marriott Florence I-20, where secure rooms begin at $179.99, creating a warm and welcoming space ideal for relaxation. Celebrate your special occasions at Fairfield, where attentive service and comfortable accommodations welcome groups of all sizes.

Guests staying at Fairfield Inn & Suites by Marriott Florence I-20 will appreciate the peaceful surroundings, while downtown Jernigan Crossroads is still within easy reach for a day’s adventures. Discover the smart way to experience Jernigan Crossroads with thoughtfully priced lodging—lock in today!

  Call (855) 233-0132 to book with an agent.
  6.7 miles from Jernigan Crossroads, SC 29532

Starting at

$179.99

per night

Read Reviews View Amenities View All Rooms

Raceway Inn

705 Washington St Darlington, SC

With budget-friendly rooms starting at $60.99, Raceway Inn provides inviting accommodations for travelers to Jernigan Crossroads, creating a intimate-feeling environment. Enjoy a stay designed for convenience and value, where rooms are equipped with necessary amenities for a comfortable visit.

Guests staying at Raceway Inn will love how close they are to downtown Jernigan Crossroads, where a short drive delivers them to the city’s top destinations. Discover the best way to enjoy Jernigan Crossroads with cost-effective, practical accommodations—secure now!

  Call (855) 239-5277 to book with an agent.
  6.9 miles from Jernigan Crossroads, SC 29532

Starting at

$60.99

per night

Read Reviews View Amenities View All Rooms

Tru by Hilton Florence I-95

2140 West Lucas Street Florence, SC

With rooms starting at $138.99, Tru by Hilton Florence I-95 provides affordable accommodations for travelers visiting Jernigan Crossroads, creating a pleasant and comfortable atmosphere. Enjoy the complimentary 'Top It' breakfast bar at Tru by Hilton, featuring a wide selection of sweet and savory toppings for your morning meal.

At Tru by Hilton Florence I-95, guests can relax in a quieter environment, with downtown Jernigan Crossroads still within easy reach for a day of exploring. Rest easy in Jernigan Crossroads with budget-wise lodging designed for your comfort—lock in today!

  Call (855) 239-4019 to book with an agent.
  8.3 miles from Jernigan Crossroads, SC 29532

Starting at

$138.99

per night

Read Reviews View Amenities View All Rooms

Hampton Inn & Suites Florence North I-95

1735 Stokes Road Florence, SC

At Hampton Inn & Suites Florence North I-95, travelers to Jernigan Crossroads will find budget-friendly rooms with rates starting at $134.99, creating a clean, welcoming environment perfect for rest. Kickstart your day with a premium coffee from Hampton’s select coffee brands, ensuring a high-quality brew to wake you up right.

Guests at Hampton Inn & Suites Florence North I-95 will love the quiet surroundings, with downtown Jernigan Crossroads still within easy reach for all their sightseeing and exploration needs. Enjoy the beauty of Jernigan Crossroads with a hotel that keeps your budget intact—book today!

  Call (855) 239-5277 to book with an agent.
  8.3 miles from Jernigan Crossroads, SC 29532

Starting at

$134.99

per night

Read Reviews View Amenities View All Rooms

Comfort Suites Florence I-95

2120 West Lucas Street Florence, SC

For a welcoming and budget-friendly stay, Comfort Suites Florence I-95 offers inviting rooms with rates from $141.99, creating a harmonious space ideal for travelers bound for Jernigan Crossroads. Connect effortlessly with complimentary high-speed Wi-Fi at Comfort Suites, perfect for both leisure and business travelers.

Guests staying at Comfort Suites Florence I-95 will appreciate the balance of easy city access and the calm of a quieter setting further from downtown Jernigan Crossroads. Make the most of Jernigan Crossroads with a hotel that pairs convenience with savings—lock in now!

  Call (855) 233-7850 to book with an agent.
  8.3 miles from Jernigan Crossroads, SC 29532

Starting at

$141.99

per night

Read Reviews View Amenities View All Rooms

Microtel Inn & Suites by Wyndham Florence

1912 Enterprise Dr Florence, SC

For an affordable and restful stay, Microtel Inn & Suites by Wyndham Florence offers inviting accommodations with rooms starting at $77.99, creating a warm, welcoming space ideal for relaxation. Relax in tastefully decorated rooms at Microtel, where modern furnishings and thoughtful amenities ensure a pleasant stay.

From Microtel Inn & Suites by Wyndham Florence, the drive to downtown Jernigan Crossroads is quick and convenient, allowing guests to explore the city’s attractions while returning to a quieter retreat. Enjoy Jernigan Crossroads with a hotel that keeps your comfort and budget in mind—reserve today!

  Call (855) 235-0725 to book with an agent.
  8.4 miles from Jernigan Crossroads, SC 29532

Starting at

$77.99

per night

Read Reviews View Amenities View All Rooms

Park Inn by Radisson Florence SC

1729 Mandeville Road Florence, SC

Guests visiting Jernigan Crossroads can relax in secure comfort at Park Inn by Radisson Florence SC, where budget-friendly rooms start at $128.99, creating a warm, welcoming space. Experience the global presence of Radisson, with hotels and resorts located in some of the world's most sought-after destinations.

At Park Inn by Radisson Florence SC, guests can enjoy the comfort of being further from the city’s busiest areas, with downtown Jernigan Crossroads still just a trip away. Make Jernigan Crossroads travel a breeze with a hotel that blends comfort and savings—secure now!

  Call (855) 235-0725 to book with an agent.
  8.4 miles from Jernigan Crossroads, SC 29532

Starting at

$128.99

per night

Read Reviews View Amenities View All Rooms

Sleep Inn Florence North

1833 Florence Park Dr Florence, SC

With rooms starting at $73.99, Sleep Inn Florence North provides affordable accommodations for travelers visiting Jernigan Crossroads, creating a peaceful and comfortable atmosphere. Welcome to Sleep Inn, where modern design meets exceptional comfort in an affordable lodging experience.

From Sleep Inn Florence North, the drive into downtown Jernigan Crossroads is simple and convenient, making it easy for guests to explore the city while enjoying a more relaxed stay. Relax and recharge in Jernigan Crossroads with a hotel that offers more for less—secure today!

  Call (855) 233-7850 to book with an agent.
  8.4 miles from Jernigan Crossroads, SC 29532

Starting at

$73.99

per night

Read Reviews View Amenities View All Rooms