The best deals on hotels when visiting Mayo in Florida.

From game day to getaway, save even more on every hotel stay.

Save up to 70% when booking as a group. Select 9+ rooms to get started.

Top 24 Hotels In Mayo, Florida 32066

Cindys Motel

487 West Main St Mayo, FL

At Cindys Motel, travelers to Mayo can unwind in inviting rooms with rates starting at $85.99, providing a clean and comfortable space ideal for relaxation. Stay in accommodations that offer a bit more luxury and convenience, making your visit enjoyable and budget-friendly.

Guests staying at Cindys Motel can enjoy the luxury of being near Mayo’s city center, where the best restaurants, shops, and cultural landmarks are always within reach. Discover how great your Mayo visit can be with thoughtfully priced lodging—lock in today!

  Call (855) 234-7135 to book with an agent.
  0.3 miles from Mayo, FL 32066

Starting at

$85.99

per night

Read Reviews View Amenities View All Rooms

Quality Inn & Suites Live Oak I-10 Exit 283

6819 Us Highway 129 Live Oak, FL

With rates from $114.99, Quality Inn & Suites Live Oak I-10 Exit 283 provides inviting accommodations for guests bound for Mayo, creating a harmonious and comfortable atmosphere for relaxation. Enjoy the convenience of on-site laundry facilities at Quality Inn, ideal for refreshing your wardrobe during longer stays.

At Quality Inn & Suites Live Oak I-10 Exit 283, you can enjoy both restful accommodations and the easy access to Mayo's vibrant downtown area. Stay in style and save while visiting Mayo with accommodations that meet your needs—secure now!

  Call (855) 234-2997 to book with an agent.
  21.9 miles from Mayo, FL 32066

Starting at

$114.99

per night

Read Reviews View Amenities View All Rooms

Econo Lodge Live Oak

6811 North Us 129 & I 10 Live Oak, FL

At Econo Lodge Live Oak, travelers to Mayo can enjoy safe accommodations with rates starting at $88.00, creating a clean and welcoming space perfect for unwinding. Discover the convenience of Econo Lodge's on-site amenities, designed to meet the needs of today's budget-conscious traveler.

Discover the perfect escape at Econo Lodge Live Oak, where the peaceful ambiance is matched by the convenience of Mayo's nearby attractions. Lock in your Mayo trip with an inviting, cost-effective hotel—reserve now!

  Call (855) 235-6136 to book with an agent.
  22.8 miles from Mayo, FL 32066

Starting at

$88.00

per night

Read Reviews View Amenities View All Rooms

Holiday Inn Express Hotel & Suites PERRY an IHG Hotel

601 Everett Way Perry, FL

For an affordable and restful stay, Holiday Inn Express Hotel & Suites PERRY an IHG Hotel offers reassuring comfort with rates starting at $219.00, creating a warm and welcoming environment ideal for relaxation. Stay informed with Holiday Inn Express's onsite newsstands, offering the latest magazines and newspapers for guest enjoyment.

At Holiday Inn Express Hotel & Suites PERRY an IHG Hotel, guests enjoy both relaxation and easy access to Mayo, making it a great choice for a balanced getaway. Stay worry-free in Mayo with a hotel that makes affordability feel luxurious—book today!

  Call (855) 234-5074 to book with an agent.
  23.7 miles from Mayo, FL 32066

Starting at

$219.00

per night

Read Reviews View Amenities View All Rooms

Hampton Inn by Hilton Perry

2399 South Byron Butler Parkway Perry, FL

At Hampton Inn by Hilton Perry, travelers bound for Mayo can unwind in plush rooms with rates starting at $185.22, creating a warm and welcoming environment. Rely on the consistent quality and service that Hampton by Hilton offers, where you can expect the same high standards at any location.

Stay at Hampton Inn by Hilton Perry for a blend of relaxation and exploration, with quiet lodgings and close proximity to Mayo. Enjoy your time in Mayo with a hotel that’s both practical and inviting—reserve your room now!

  Call (855) 234-5074 to book with an agent.
  24.0 miles from Mayo, FL 32066

Starting at

$185.22

per night

Read Reviews View Amenities View All Rooms

Best Western Plus Madison

167 South Bandit Street Madison, FL

For a comfortable stay, Best Western Plus Madison offers budget-friendly rooms with rates beginning at $132.99, creating a clean and inviting space ideal for relaxation. Take advantage of the 24-hour business centers at Best Western Plus, fully equipped for your connectivity and productivity needs.

At Best Western Plus Madison, guests can recharge in peaceful surroundings and still have the option to explore the sights of Mayo. Discover how great your Mayo visit can be with thoughtfully priced lodging—lock in today!

  Call (855) 234-5074 to book with an agent.
  26.2 miles from Mayo, FL 32066

Starting at

$132.99

per night

Read Reviews View Amenities View All Rooms

Super 8 by Wyndham Madison

6246 State Rd. 53 South Madison, FL

For a soft and budget-friendly experience near Mayo, Super 8 by Wyndham Madison offers inviting rooms with rates from $87.99, creating a clean and welcoming space. Rest assured with Super 8's heightened cleanliness standards, offering a safe and spotless environment during your stay.

Relax and retreat at Super 8 by Wyndham Madison, a serene getaway where the excitement of Mayo is always within easy access. Enjoy more of Mayo with budget-friendly, inviting accommodations—book now!

  Call (855) 235-6136 to book with an agent.
  26.3 miles from Mayo, FL 32066

Starting at

$87.99

per night

Read Reviews View Amenities View All Rooms

Days Inn by Wyndham Madison

6160 South State Rd. 53 Madison, FL

For budget-conscious guests visiting Mayo, Days Inn by Wyndham Madison offers welcoming rooms with rates starting at $88.99, creating a warm and welcoming environment perfect for relaxation. Depend on Days Inn for consistent comfort and service, offering an affordable stay without compromising on quality.

Take a break from the city noise at Days Inn by Wyndham Madison, offering restful accommodations and quick access to Mayo's best spots. Make your Mayo adventure affordable and stress-free—lock in your room today!

  Call (855) 233-7850 to book with an agent.
  26.6 miles from Mayo, FL 32066

Starting at

$88.99

per night

Read Reviews View Amenities View All Rooms

Putnam Lodge Hotel&Spa

15487 Northwest Highway 19 Cross City, FL

At Putnam Lodge Hotel&Spa, travelers bound for Mayo can unwind in serene comfort with rooms starting at $133.00, creating a warm and welcoming space for relaxation. Find a cozy and affordable stay in rooms that provide a comfortable sleeping environment and basic conveniences.

Enjoy spacious rooms at Putnam Lodge Hotel&Spa, a quiet retreat where you can unwind and still explore Mayo with ease. Relax in Mayo with well-appointed lodging at a wallet-friendly rate—reserve today!

  Call (855) 233-0132 to book with an agent.
  28.4 miles from Mayo, FL 32066

Starting at

$133.00

per night

Read Reviews View Amenities View All Rooms

Quality Inn White Springs Suwanee

3119 County Rd. 136 Live Oak, FL

With budget-friendly rooms beginning at $88.40, Quality Inn White Springs Suwanee provides comfortable accommodations for travelers to Mayo, creating a welcoming environment for rest. Appreciate the peace of mind provided by Quality Inn's emergency response plans, ensuring your safety throughout your stay.

Enjoy the best of both relaxation and convenience at Quality Inn White Springs Suwanee, where guests can unwind and still reach Mayo with ease. Make your Mayo travels both fun and affordable with thoughtfully designed accommodations—secure today!

  Call (855) 233-0132 to book with an agent.
  28.6 miles from Mayo, FL 32066

Starting at

$88.40

per night

Read Reviews View Amenities View All Rooms

Fiddlers Restaurant&Resort

1306 Riverside Dr Steinhatchee, FL

For a gentle and affordable stay, Fiddlers Restaurant&Resort offers inviting accommodations with rates from $99.99, creating a clean and welcoming space perfect for relaxation. Stay in a room that provides dependable comfort and practical amenities, ensuring a pleasant and affordable stay.

Find both comfort and convenience at Fiddlers Restaurant&Resort, where you can rest in peaceful surroundings and still visit Mayo with ease. Lock in an affordable hotel with extra comfort for your Mayo trip—reserve now!

  Call (855) 236-8982 to book with an agent.
  29.0 miles from Mayo, FL 32066

Starting at

$99.99

per night

Read Reviews View Amenities View All Rooms

Americas Best Value Inn Lake City

3835 West US Highway 90 Lake City, FL

With rates starting at $67.99, Americas Best Value Inn Lake City offers budget-conscious comfort for travelers headed to Mayo, creating a pleasant, inviting environment perfect for relaxation. Enjoy a quiet rest in our quiet rooms, designed to provide a restful and undisturbed sleep environment.

Discover the quiet charm of Americas Best Value Inn Lake City, a relaxing retreat that’s never too far from the bustling streets of Mayo. Make your Mayo adventure affordable and stress-free—lock in your room today!

  Call (855) 234-2997 to book with an agent.
  30.1 miles from Mayo, FL 32066

Starting at

$67.99

per night

Read Reviews View Amenities View All Rooms

Gateway Inn

3783 West US Highway 90 Lake City, FL

For a welcoming and affordable stay, Gateway Inn offers budget-friendly rooms with rates beginning at $61.99, creating a clean and comfortable space. Enjoy a straightforward lodging experience, where rooms provide basic amenities, clean surroundings, and friendly service.

Escape the hustle and bustle of the city at Gateway Inn, while staying close enough to explore everything Mayo has to offer. Step into Mayo comfort with a hotel that prioritizes both convenience and savings—book today!

  Call (855) 239-5277 to book with an agent.
  30.1 miles from Mayo, FL 32066

Starting at

$61.99

per night

Read Reviews View Amenities View All Rooms

Comfort Suites Lake City

3690 West Us Highway 90 Lake City, FL

For a comfortable and inviting stay, Comfort Suites Lake City offers charming rooms with rates beginning at $141.99, creating a clean and comfortable space near Mayo. Enjoy the convenience of direct booking benefits at Comfort Suites, including exclusive rates and personalized service.

Relax and recharge at Comfort Suites Lake City, where a quiet setting provides the perfect escape with Mayo's attractions just minutes away. Enjoy Mayo in comfort and without financial stress—book your room today!

  Call (855) 235-0725 to book with an agent.
  30.2 miles from Mayo, FL 32066

Starting at

$141.99

per night

Read Reviews View Amenities View All Rooms

Baymont by Wyndham Lake City

3598 West Us Highway 90 Lake City, FL

Guests traveling to Mayo will find inviting accommodations at Baymont by Wyndham Lake City, where soothing rooms start at $58.99, creating a welcoming space ideal for relaxation. Relax and unwind in Baymont by Wyndham’s whirlpool or spa facilities, available at select locations for an added touch of luxury.

Find your ideal retreat at Baymont by Wyndham Lake City, a serene escape found just a short drive from the dynamic atmosphere of Mayo. Find the perfect place to rest after exploring Mayo with budget-friendly lodging—secure today!

  Call (855) 239-4019 to book with an agent.
  30.3 miles from Mayo, FL 32066

Starting at

$58.99

per night

Read Reviews View Amenities View All Rooms

Tru by Hilton Lake City

284 North Centurion Court Lake City, FL

For an affordable and restful stay near Mayo, Tru by Hilton Lake City offers budget-friendly accommodations with rooms starting at $162.99, creating a welcoming space. Stay engaged with the unique wall murals at Tru by Hilton, depicting local landmarks and cultural themes of the area.

Escape to Tru by Hilton Lake City for a relaxing stay, with the added benefit of being close to the exciting venues in Mayo. Relax and explore Mayo knowing your accommodations provide excellent value—book today!

  Call (855) 233-7850 to book with an agent.
  30.4 miles from Mayo, FL 32066

Starting at

$162.99

per night

Read Reviews View Amenities View All Rooms

Econo Lodge Lake City North

178 South Florida Gateway Dr Lake City, FL

With rooms starting at $90.99, Econo Lodge Lake City North offers budget-friendly accommodations for guests visiting Mayo, creating a pleasant space ideal for a relaxing stay. Choose Econo Lodge for its mix of essential hotel amenities and friendly service, ensuring a pleasant and affordable stay.

Recharge in the comfort of Econo Lodge Lake City North, where guests can unwind in peace while keeping Mayo within reach for exploration. Book an inviting hotel that won’t break the bank for your Mayo visit—secure today!

  Call (855) 239-4019 to book with an agent.
  30.4 miles from Mayo, FL 32066

Starting at

$90.99

per night

Read Reviews View Amenities View All Rooms

Fairfield Inn & Suites Lake City

538 South Corporate Dr Lake City, FL

At Fairfield Inn & Suites Lake City, travelers bound for Mayo will find budget-conscious comfort with rooms starting at $174.99, creating a clean, inviting space for relaxation. Indulge in the peace of mind that comes with staying at Fairfield, where safety and security are top priorities for all guests.

Step into the calm of Fairfield Inn & Suites Lake City, where quiet rooms are paired with the excitement of Mayo just a short drive away. Find comfort and convenience in Mayo at a rate that fits your budget—book now!

  Call (855) 236-8982 to book with an agent.
  30.4 miles from Mayo, FL 32066

Starting at

$174.99

per night

Read Reviews View Amenities View All Rooms

Hampton Inn & Suites Lake City

450 South Florida Gateway Drive Lake City, FL

Guests traveling to Mayo will find inviting accommodations at Hampton Inn & Suites Lake City, with rooms starting at $181.99, creating a clean and welcoming environment ideal for relaxation. Savor the convenience of Hampton’s express breakfast options, designed for guests needing a quick and nutritious start to their busy days.

Relax at Hampton Inn & Suites Lake City, where a tranquil environment offers the perfect getaway with Mayo's highlights just a short drive away. Uncover value-driven comfort that makes Mayo travel easy—book your stay today!

  Call (855) 236-8982 to book with an agent.
  30.4 miles from Mayo, FL 32066

Starting at

$181.99

per night

Read Reviews View Amenities View All Rooms

Best Western Plus Lake City

350 South Florida Gateway Dr Lake City, FL

Guests traveling to Mayo will appreciate the inviting comfort at Best Western Plus Lake City, where budget-friendly rooms start at $123.99, creating a warm, welcoming environment. Relax in the dedicated meditation and quiet rooms available at Best Western Plus, offering a space for reflection and relaxation.

Experience the tranquility of Best Western Plus Lake City, where a peaceful stay is complemented by the nearby attractions of Mayo. Experience Mayo without overspending with a hotel that enhances your visit—lock in now!

  Call (855) 235-0725 to book with an agent.
  30.5 miles from Mayo, FL 32066

Starting at

$123.99

per night

Read Reviews View Amenities View All Rooms

Quality Inn Lake City

285 South Commerce Dr Lake City, FL

With budget-friendly rooms starting at $92.99, Quality Inn Lake City provides inviting accommodations for those bound for Mayo, creating a clean, welcoming space. Enjoy freshly brewed coffee in the lobby of Quality Inn, a welcome treat to energize your mornings or afternoons.

Stay at Quality Inn Lake City to enjoy spacious comfort, with the convenience of Mayo's lively offerings just minutes away. Stay affordably and enjoy the best of Mayo with a hotel that understands your needs—lock in today!

  Call (855) 236-8982 to book with an agent.
  30.6 miles from Mayo, FL 32066

Starting at

$92.99

per night

Read Reviews View Amenities View All Rooms

Rodeway Inn Lake City I-75

205 South Commerce Dr Lake City, FL

Guests traveling to Mayo can unwind at Rodeway Inn Lake City I-75, where budget-friendly rooms start at $65.99, providing a warm and welcoming space perfect for rest. Experience practical comfort in a setting that focuses on value and essential amenities, ideal for economical travels.

Enjoy spacious rooms at Rodeway Inn Lake City I-75, a quiet retreat where you can unwind and still explore Mayo with ease. Stay affordably and comfortably while visiting Mayo—reserve your room today!

  Call (855) 233-7850 to book with an agent.
  30.6 miles from Mayo, FL 32066

Starting at

$65.99

per night

Read Reviews View Amenities View All Rooms

Knights Inn Lake City

339 South COMMERCE DR Lake City, FL

With affordable rooms from $55.99, Knights Inn Lake City provides budget-friendly comfort for those bound for Mayo, creating a delightful and relaxing space. Appreciate the smoking and non-smoking room options at Knights Inn, catering to different guest preferences.

Find your peaceful retreat at Knights Inn Lake City, found within a comfortable distance from the bustling streets of Mayo. Lock in a budget-friendly Mayo stay and maximize your travel experience—book now!

  Call (855) 239-5277 to book with an agent.
  30.6 miles from Mayo, FL 32066

Starting at

$55.99

per night

Read Reviews View Amenities View All Rooms

Holiday Inn & Suites Lake City an IHG Hotel

213 South Commerce Dr Lake City, FL

Experience a peaceful retreat at Holiday Inn & Suites Lake City an IHG Hotel as you travel to Mayo, where inviting rooms create a hospitable ambiance, with rates starting from $142.49 per night. Experience the joy of Holiday Inn's themed weekends, featuring special activities and dining options for a memorable stay.

Find your ideal getaway at Holiday Inn & Suites Lake City an IHG Hotel, where quiet surroundings and quick access to Mayo ensure a balanced stay. Stay in Mayo with a hotel that promises comfort, style, and budget-friendly rates—book today!

  Call (855) 235-0725 to book with an agent.
  30.7 miles from Mayo, FL 32066

Starting at

$142.49

per night

Read Reviews View Amenities View All Rooms