The best deals on hotels when visiting Pepsin in Missouri.

From game day to getaway, save even more on every hotel stay.

Save up to 70% when booking as a group. Select 9+ rooms to get started.

Top 24 Hotels In Pepsin, Missouri 64862

Super 8 by Wyndham Carthage

416 West Fir Rd Carthage, MO

Guests bound for Pepsin will appreciate the enveloping accommodations at Super 8 by Wyndham Carthage, with rooms starting at $67.99, providing a warm, welcoming space for rest. Keep cool and comfortable in Super 8's air-conditioned rooms, a welcome feature during those hot summer days.

With a simple drive into downtown Pepsin, guests at Super 8 by Wyndham Carthage can enjoy the city’s highlights without sacrificing the calm of their stay. Plan a practical, budget-friendly stay for your Pepsin travels—book today!

  Call (855) 236-8982 to book with an agent.
  9.0 miles from Pepsin, MO 64862

Starting at

$67.99

per night

Read Reviews View Amenities View All Rooms

Quality Inn&Suites

2701 Hazel Carthage, MO

With rooms starting at $65.99, Quality Inn&Suites provides inviting accommodations for guests traveling to Pepsin, creating a inviting, welcoming environment. Work comfortably from your room at Quality Inn, equipped with dedicated workspaces designed for productivity.

At Quality Inn&Suites, guests can relax in the quiet surroundings of the hotel, while downtown Pepsin remains accessible for easy city exploration. Make your Pepsin experience stress-free with a hotel that offers unbeatable value—book today!

  Call (855) 239-5277 to book with an agent.
  9.3 miles from Pepsin, MO 64862

Starting at

$65.99

per night

Read Reviews View Amenities View All Rooms

Carthage Inn

2244 Grand Ave Carthage, MO

For those headed to Pepsin, Carthage Inn offers budget-friendly accommodations with rooms from $59.99, creating a clean, comfortable environment perfect for rest. Find a cozy and affordable stay in rooms that provide a comfortable sleeping environment and basic conveniences.

With downtown Pepsin still within reach by car, guests at Carthage Inn can enjoy the city’s highlights while benefiting from a more relaxed, quieter stay. Enjoy your Pepsin visit with a hotel that combines convenience and value perfectly—lock in today!

  Call (855) 233-0132 to book with an agent.
  9.5 miles from Pepsin, MO 64862

Starting at

$59.99

per night

Read Reviews View Amenities View All Rooms

Guest House Motel

417 East Central Avenue Carthage, MO

Guests bound for Pepsin will find intimate-feeling accommodations at Guest House Motel, with rooms beginning at $69.99, creating a welcoming, comfortable atmosphere ideal for relaxation. Relax in rooms that are designed for travelers seeking practical accommodations with a focus on cleanliness and comfort.

A peaceful stay awaits at Guest House Motel, where tranquil surroundings combine with easy access to downtown Pepsin. Relax in Pepsin with a hotel that delivers convenience and savings—secure your room today!

  Call (855) 233-7850 to book with an agent.
  11.3 miles from Pepsin, MO 64862

Starting at

$69.99

per night

Read Reviews View Amenities View All Rooms

Days Inn by Wyndham Carthage

1441 West Central Ave Carthage, MO

At Days Inn by Wyndham Carthage, guests traveling to Pepsin can unwind in budget-conscious accommodations with rooms beginning at $83.99, creating a warm and inviting space. Depend on Days Inn for consistent comfort and service, offering an affordable stay without compromising on quality.

At Days Inn by Wyndham Carthage, visitors can find relaxation in peaceful surroundings, with downtown Pepsin still accessible for a day of sightseeing. Stay comfortably and affordably while visiting Pepsin—reserve your room now!

  Call (855) 235-6136 to book with an agent.
  11.8 miles from Pepsin, MO 64862

Starting at

$83.99

per night

Read Reviews View Amenities View All Rooms

Best Budget Inn

13008 State Highway 96 Carthage, MO

Guests headed to Pepsin can relax at Best Budget Inn, where budget-friendly rooms start at $70.00, creating a warm, welcoming atmosphere perfect for a peaceful stay. Enjoy a setting that blends affordability with comfort, where each room is equipped with everything needed for a restful stay.

At Best Budget Inn, visitors can enjoy peaceful surroundings, knowing downtown Pepsin is still close enough for a day of sightseeing. Enjoy extra perks and budget-friendly rates on your Pepsin trip—reserve today!

  Call (855) 236-8982 to book with an agent.
  11.9 miles from Pepsin, MO 64862

Starting at

$70.00

per night

Read Reviews View Amenities View All Rooms

Residence Inn Marriott Joplin

3128 East Hammons Blvd Joplin, MO

Experience a welcoming stay at Residence Inn Marriott Joplin as you explore Pepsin, where inviting rooms offer a peaceful retreat, with budget-friendly rates beginning at $149.99. Relax and rejuvenate in Residence Inn's well-appointed bathrooms, complete with luxurious toiletries and plush towels.

Guests at Residence Inn Marriott Joplin will find a peaceful escape, while downtown Pepsin remains easily accessible for a day of sightseeing. Plan an unforgettable Pepsin trip with accommodations that make every moment enjoyable—reserve now!

  Call (855) 233-7850 to book with an agent.
  12.9 miles from Pepsin, MO 64862

Starting at

$149.99

per night

Read Reviews View Amenities View All Rooms

Econo Lodge Inn & Suites Joplin

3510 South Range Line Rd Joplin, MO

For a comfortable and budget-friendly stay, Econo Lodge Inn & Suites Joplin offers appealing rooms with rates from $55.99, creating a welcoming, clean environment near Pepsin. Value your stay at Econo Lodge, where essential accommodations are provided without unnecessary extravagance, ensuring a great price.

At Econo Lodge Inn & Suites Joplin, guests can unwind in a calm environment, with downtown Pepsin still close enough for all their city adventures. Enjoy Pepsin with an inviting hotel that balances comfort and savings—book now!

  Call (855) 233-7850 to book with an agent.
  13.2 miles from Pepsin, MO 64862

Starting at

$55.99

per night

Read Reviews View Amenities View All Rooms

Super 8 by Wyndham Joplin

2830 East 36th Street Joplin, MO

At Super 8 by Wyndham Joplin, travelers visiting Pepsin can enjoy restful, affordable rooms starting at $78.00, creating a comfortable, inviting environment ideal for relaxation. Experience serene slumber in Super 8’s cozy accommodations, where comfort is prioritized to rejuvenate travelers.

For a quiet retreat, Super 8 by Wyndham Joplin offers peaceful surroundings, with downtown Pepsin still within reach for a day of city exploration. Save more and experience added comfort on your Pepsin visit—book your room now!

  Call (855) 233-0132 to book with an agent.
  13.2 miles from Pepsin, MO 64862

Starting at

$78.00

per night

Read Reviews View Amenities View All Rooms

Days Inn by Wyndham Joplin

3500 South Rangeline RD Joplin, MO

With budget-friendly rooms from $68.99, Days Inn by Wyndham Joplin is a convenient choice for travelers bound for Pepsin, creating a warm and comfortable space. Explore dining and shopping options nearby, with many Days Inn properties located close to local eateries and malls.

At Days Inn by Wyndham Joplin, guests can experience quiet surroundings while keeping downtown Pepsin within reach for a day of adventure. Enjoy more of Pepsin with a budget-friendly, comfortable hotel—book now!

  Call (855) 233-7850 to book with an agent.
  13.2 miles from Pepsin, MO 64862

Starting at

$68.99

per night

Read Reviews View Amenities View All Rooms

La Quinta Inn & Suites by Wyndham Joplin

3320 South Range Line Rd Joplin, MO

At La Quinta Inn & Suites by Wyndham Joplin, travelers visiting Pepsin can enjoy inviting accommodations with rooms from $108.99, creating a clean and welcoming environment ideal for rest. Stay hydrated with complimentary bottled water provided daily in your room at La Quinta.

Rest in the peaceful surroundings of La Quinta Inn & Suites by Wyndham Joplin, while knowing downtown Pepsin is just a convenient drive away for your city adventures. Choose a hotel that takes your Pepsin experience to the next level—book now!

  Call (855) 239-5277 to book with an agent.
  13.2 miles from Pepsin, MO 64862

Starting at

$108.99

per night

Read Reviews View Amenities View All Rooms

Fairfield Inn by Marriott Joplin

3301 South Rangeline Rd Joplin, MO

For an inviting stay, Fairfield Inn by Marriott Joplin offers alluring rooms with rates starting at $124.99, creating a warm and welcoming space near Pepsin. Indulge in Fairfield’s bakery corner, featuring fresh pastries and breads baked daily on the premises.

For those seeking a blend of relaxation and city exploration, Fairfield Inn by Marriott Joplin offers tranquility with downtown Pepsin a drive away. Stay smart and relaxed in Pepsin with value-driven amenities—book your room now!

  Call (855) 233-7850 to book with an agent.
  13.2 miles from Pepsin, MO 64862

Starting at

$124.99

per night

Read Reviews View Amenities View All Rooms

Best Western The Oasis at Joplin

3508 South Rangeline Road Joplin, MO

At Best Western The Oasis at Joplin, travelers bound for Pepsin will find inviting comfort with rooms beginning at $86.99, creating a clean and welcoming space perfect for relaxation. Experience the personal touch of Best Western's staff, who are trained to provide unparalleled service and attention to detail.

For those who want to enjoy both relaxation and city access, Best Western The Oasis at Joplin provides the perfect blend, with downtown Pepsin just a drive away. Make Pepsin travel simple with a hotel that provides convenience and savings—reserve now!

  Call (855) 234-5074 to book with an agent.
  13.2 miles from Pepsin, MO 64862

Starting at

$86.99

per night

Read Reviews View Amenities View All Rooms

Microtel Inn & Suites by Wyndham Joplin

4101 Richard Joseph Blvd Joplin, MO

With rooms beginning at $73.00, Microtel Inn & Suites by Wyndham Joplin offers budget-friendly accommodations for travelers bound for Pepsin, creating a cushy, comfortable space. Enjoy the refined aesthetics of Microtel’s bathrooms, which offer ample space and modern fixtures to start your day refreshed.

A peaceful stay awaits at Microtel Inn & Suites by Wyndham Joplin, where tranquil surroundings combine with easy access to downtown Pepsin. Save more and experience added comfort on your Pepsin visit—book your room now!

  Call (855) 239-4019 to book with an agent.
  13.2 miles from Pepsin, MO 64862

Starting at

$73.00

per night

Read Reviews View Amenities View All Rooms

TownePlace Suites Marriott Joplin

4026 South Arizona Avenue Joplin, MO

Guests visiting Pepsin will appreciate the inviting comfort at TownePlace Suites Marriott Joplin, with budget-friendly rooms starting at $119.99, creating a clean, welcoming space. Enjoy the community atmosphere of TownePlace Suites' shared dining and lounge areas, where guests can socialize and relax.

At TownePlace Suites Marriott Joplin, travelers will appreciate the calm surroundings, while downtown Pepsin is still nearby for a day of adventure. Experience Pepsin with peace of mind, knowing your hotel offers great savings—book now!

  Call (855) 236-8982 to book with an agent.
  13.3 miles from Pepsin, MO 64862

Starting at

$119.99

per night

Read Reviews View Amenities View All Rooms

Candlewood Suites Joplin an IHG Hotel

3512 South Rangeline Rd Joplin, MO

At Candlewood Suites Joplin an IHG Hotel, travelers visiting Pepsin can enjoy inviting comfort with rooms beginning at $124.00, creating a warm and welcoming atmosphere ideal for rest. Ample parking is available at Candlewood Suites, adding ease to your visits with personal or rental vehicles.

Relax in the serene environment at Candlewood Suites Joplin an IHG Hotel, with the vibrant energy of downtown Pepsin still within reach for a day trip. Discover the ideal way to visit Pepsin with a hotel that values your comfort—secure now!

  Call (855) 234-7135 to book with an agent.
  13.3 miles from Pepsin, MO 64862

Starting at

$124.00

per night

Read Reviews View Amenities View All Rooms

Home2 Suites by Hilton Joplin MO

3000 South RANGELINE RD Joplin, MO

Home2 Suites by Hilton Joplin MO provides a welcoming stay for travelers to Pepsin, where inviting rooms create a secure environment, with affordable rates starting at $147.99. Explore the area with confidence, as many Home2 Suites locations are conveniently situated near attractions, dining, and shopping.

Guests staying at Home2 Suites by Hilton Joplin MO will appreciate the calm atmosphere, while downtown Pepsin is just a short drive away for exploration. Unwind after exploring Pepsin with a hotel that’s dedicated to your comfort—lock in today!

  Call (855) 235-0725 to book with an agent.
  13.3 miles from Pepsin, MO 64862

Starting at

$147.99

per night

Read Reviews View Amenities View All Rooms

Quality Inn Joplin I-44

3325 Arizona Ave Joplin, MO

With budget-friendly rooms from $80.99, Quality Inn Joplin I-44 is an ideal choice for guests traveling to Pepsin, creating a clean and inviting space for unwinding. Stay refreshed with Quality Inn's poolside bar service, offering drinks and snacks while you relax by the water.

Unwind at Quality Inn Joplin I-44, where peaceful surroundings set the tone for a restful stay, and downtown Pepsin remains a short drive away. Choose a hotel that makes your Pepsin trip both practical and enjoyable—secure your stay today!

  Call (855) 239-4019 to book with an agent.
  13.3 miles from Pepsin, MO 64862

Starting at

$80.99

per night

Read Reviews View Amenities View All Rooms

Holiday Inn Joplin an IHG Hotel

3402 South Arizona Ave Joplin, MO

Unwind at Holiday Inn Joplin an IHG Hotel as you explore Pepsin, where restful accommodations offer comfort and relaxation, with inviting rates starting at $139.00. Leave your luggage with Holiday Inn’s secure storage service before check-in or after check-out, allowing you to explore freely.

For a calm getaway, Holiday Inn Joplin an IHG Hotel offers serene surroundings while keeping downtown Pepsin within reach for sightseeing. Get ready for a Pepsin stay that’s as comfortable as it is memorable—lock in today!

  Call (855) 234-5074 to book with an agent.
  13.3 miles from Pepsin, MO 64862

Starting at

$139.00

per night

Read Reviews View Amenities View All Rooms

Homewood Suites by Hilton Joplin

2642 East 32nd Street Joplin, MO

Enjoy quality accommodations at Homewood Suites by Hilton Joplin on your trip to Pepsin, where restful rooms offer comfort, with nightly rates starting from a friendly $170.99. Enjoy a sustainable stay with Homewood Suites' initiatives like water conservation programs and energy-efficient appliances.

Unwind at Homewood Suites by Hilton Joplin, where quiet surroundings offer a restful stay and downtown Pepsin remains conveniently accessible. Unwind in Pepsin with a hotel that offers superior comfort and excellent value—lock in today!

  Call (855) 233-7850 to book with an agent.
  13.8 miles from Pepsin, MO 64862

Starting at

$170.99

per night

Read Reviews View Amenities View All Rooms

Sleep Inn & Suites Webb City

221 South East Street Webb City, MO

At Sleep Inn & Suites Webb City, guests bound for Pepsin can enjoy budget-friendly accommodations with rooms starting at $91.99, creating a welcoming and comfortable space. Wake up rejuvenated at Sleep Inn, thanks to the dedicated Quiet Zones and sound-dampening construction for uninterrupted rest.

The serene environment at Sleep Inn & Suites Webb City provides a relaxing retreat, while downtown Pepsin is easily reachable by car. Discover the best value for your Pepsin stay with a hotel that won’t disappoint—reserve now!

  Call (855) 239-5277 to book with an agent.
  14.4 miles from Pepsin, MO 64862

Starting at

$91.99

per night

Read Reviews View Amenities View All Rooms

Best Western Big Spring Lodge

1810 Southern View Drive Neosho, MO

At Best Western Big Spring Lodge, travelers to Pepsin will find inviting rooms with rates from $110.99, creating a warm, welcoming space perfect for relaxation. Book your stay at Best Western, where you're guaranteed a mix of warm hospitality, comfortable rooms, and reliable service.

At Best Western Big Spring Lodge, travelers can enjoy a calm retreat while downtown Pepsin remains within easy reach for a day of sightseeing. Choose a hotel in Pepsin that keeps both your comfort and wallet in mind—reserve now!

  Call (855) 233-0132 to book with an agent.
  15.2 miles from Pepsin, MO 64862

Starting at

$110.99

per night

Read Reviews View Amenities View All Rooms

Super 8 by Wyndham Neosho

3085 Gardner Edgewood Dr Neosho, MO

For budget-conscious guests visiting Pepsin, Super 8 by Wyndham Neosho offers peaceful accommodations with rates starting at $77.99, creating a warm and welcoming environment. Enjoy traveling with pets at Super 8’s accommodating facilities, where your animal companions are treated as valued guests.

The calm environment at Super 8 by Wyndham Neosho creates a peaceful escape, with downtown Pepsin close enough for all your adventures. Enjoy Pepsin with added value and convenience—secure your hotel stay today!

  Call (855) 234-2997 to book with an agent.
  15.3 miles from Pepsin, MO 64862

Starting at

$77.99

per night

Read Reviews View Amenities View All Rooms

Booneslick Lodge of Neosho

1602 Industrial Dr Neosho, MO

For an inviting stay near Pepsin, Booneslick Lodge of Neosho offers budget-friendly rooms with rates from $72.00, creating a clean and comfortable space ideal for rest. Experience a stay that exceeds your expectations for value, with rooms providing all the necessary amenities without the fuss.

Nestled in a quieter area, Booneslick Lodge of Neosho provides guests with a serene atmosphere, while downtown Pepsin remains a short drive away. Plan your Pepsin getaway with a welcoming, economical hotel—reserve your stay today!

  Call (855) 234-5074 to book with an agent.
  15.3 miles from Pepsin, MO 64862

Starting at

$72.00

per night

Read Reviews View Amenities View All Rooms