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Top 24 Hotels In Puxico, Missouri 63960

Hickory House Inn

1802 North Outer Rd Dexter, MO

Guests bound for Puxico can enjoy inviting comfort at Hickory House Inn, where enveloping rooms begin at $54.99, creating a warm and welcoming space ideal for relaxation. Find added value in rooms that offer more amenities and comfort, designed to enhance your travel experience without stretching your budget.

A relaxing stay awaits at Hickory House Inn, where calm surroundings offer rest and downtown Puxico is a convenient drive away. Make the most of your Puxico experience with extra perks at an affordable price—book now!

  Call (855) 239-4019 to book with an agent.
  13.7 miles from Puxico, MO 63960

Starting at

$54.99

per night

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Dexter Inn

1807 West Business US Highway 60 Dexter, MO

For budget-conscious travelers headed to Puxico, Dexter Inn offers comfortable rooms starting at $62.99, creating a clean and inviting atmosphere. Enjoy a functional stay, where rooms are equipped with all the basic amenities needed for a comfortable and efficient trip.

With downtown Puxico a scenic drive away, guests at Dexter Inn can balance city adventures with the relaxing atmosphere of the hotel. Embrace added convenience and affordability on your Puxico travels—book now!

  Call (855) 234-7135 to book with an agent.
  13.8 miles from Puxico, MO 63960

Starting at

$62.99

per night

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Travelodge by Wyndham Dexter

1608 East Business US 60 Dexter, MO

Guests traveling to Puxico will find Travelodge by Wyndham Dexter a budget-friendly choice, with comfortable rooms starting at $80.99, creating a warm and relaxing environment. Discover Travelodge's family-friendly accommodations, with options suitable for guests of all ages.

At Travelodge by Wyndham Dexter, guests can unwind in calm surroundings, while downtown Puxico is still nearby for a day of sightseeing. Book a practical, inviting hotel for your Puxico adventure and save—secure now!

  Call (855) 234-5074 to book with an agent.
  13.9 miles from Puxico, MO 63960

Starting at

$80.99

per night

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Econo Lodge Dexter

913 Outer Rd Dexter, MO

At Econo Lodge Dexter, travelers bound for Puxico will find comfortable, budget-friendly accommodations with rooms beginning at $64.99, creating a warm space for rest. Trust in Econo Lodge for a reliable stay, where essential amenities and comfortable accommodations ensure a pleasant visit.

The serene environment at Econo Lodge Dexter provides a relaxing retreat, while downtown Puxico is easily reachable by car. Make your Puxico experience both enjoyable and economical—lock in your stay today!

  Call (855) 235-0725 to book with an agent.
  14.3 miles from Puxico, MO 63960

Starting at

$64.99

per night

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Bullwinkles Rustic Lodge

399 Highway T Poplar Bluff, MO

For an affordable and inviting stay, Bullwinkles Rustic Lodge offers enchanting rooms with rates beginning at $79.99, creating a clean and comfortable atmosphere near Puxico. Find comfort in rooms that cater to budget-conscious travelers, offering essential amenities and a clean, safe environment.

For a serene stay, Bullwinkles Rustic Lodge offers quiet surroundings, while downtown Puxico remains close enough for easy access. Make Puxico feel like home with well-equipped, cost-friendly accommodations—secure now!

  Call (855) 234-2997 to book with an agent.
  18.6 miles from Puxico, MO 63960

Starting at

$79.99

per night

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Comfort Inn Poplar Bluff North

2582 North Westwood Blvd Poplar Bluff, MO

For an affordable stay, Comfort Inn Poplar Bluff North offers budget-conscious accommodations with rooms beginning at $88.99, creating a clean, welcoming space near Puxico. Experience the convenience of Comfort Inn locations, strategically situated near key attractions, business centers, and transport hubs.

At Comfort Inn Poplar Bluff North, guests can unwind in peaceful surroundings, knowing that downtown Puxico is just a short drive away. Experience Puxico with accommodations that make every moment memorable—lock in now!

  Call (855) 236-8982 to book with an agent.
  18.8 miles from Puxico, MO 63960

Starting at

$88.99

per night

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Super 8 by Wyndham Poplar Bluff Missouri

2831 North Westwood Blvd Poplar Bluff, MO

With rooms beginning at $53.99, Super 8 by Wyndham Poplar Bluff Missouri provides inviting accommodations for guests bound for Puxico, creating a sheltered and comfortable atmosphere. Trust in Super 8’s rigorous cleanliness standards, which include regular sanitizing and cleaning for your safety and comfort.

With a scenic drive into downtown Puxico, guests at Super 8 by Wyndham Poplar Bluff Missouri can enjoy the city's best spots before returning to the calm of the hotel. Make your Puxico adventure budget-friendly and comfortable—reserve now!

  Call (855) 234-2997 to book with an agent.
  18.8 miles from Puxico, MO 63960

Starting at

$53.99

per night

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Holiday Inn Poplar Bluff an IHG Hotel

2781 North Westwood Blvd Poplar Bluff, MO

Experience quality and comfort at Holiday Inn Poplar Bluff an IHG Hotel as you explore Puxico, where intimate accommodations provide a relaxing environment, with rates beginning at $115.00. Book your next event with confidence at Holiday Inn’s adaptable meeting spaces, suitable for business and social gatherings.

Enjoy the quiet surroundings at Holiday Inn Poplar Bluff an IHG Hotel, where downtown Puxico remains accessible by car for a day of sightseeing and adventure. Step into Puxico relaxation with a hotel that caters to your every need—lock in today!

  Call (855) 233-7850 to book with an agent.
  18.9 miles from Puxico, MO 63960

Starting at

$115.00

per night

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Hampton Inn Poplar Bluff

2420 Crestwood Dr Poplar Bluff, MO

With rooms beginning at $103.99, Hampton Inn Poplar Bluff provides inviting accommodations for travelers bound for Puxico, creating a warm, welcoming environment. Utilize Hampton’s laundry services during longer stays, keeping your wardrobe fresh and ready for whatever your trip entails.

For a serene stay, Hampton Inn Poplar Bluff offers quiet surroundings while keeping downtown Puxico within a comfortable drive for exploration. Stay comfortably and affordably in Puxico with a hotel that delivers—secure your room now!

  Call (855) 234-2997 to book with an agent.
  18.9 miles from Puxico, MO 63960

Starting at

$103.99

per night

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Fairfield Inn & Suites by Marriott Poplar Bluff

3109 Oak Grove Poplar Bluff, MO

With rates beginning at $119.99, Fairfield Inn & Suites by Marriott Poplar Bluff provides budget-conscious accommodations for travelers visiting Puxico, creating a secure space ideal for rest. Stay on the move with Fairfield's complimentary shuttle services, offering convenient transportation to nearby airports and attractions (at select locations).

Guests at Fairfield Inn & Suites by Marriott Poplar Bluff can rest in quiet surroundings, while downtown Puxico remains nearby for a day of city exploration. Find the perfect Puxico escape with accommodations that don’t break the bank—lock in today!

  Call (855) 233-0132 to book with an agent.
  19.2 miles from Puxico, MO 63960

Starting at

$119.99

per night

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Motel 6 Poplar Bluff MO

4101 Highway 67 N Poplar Bluff, MO

Guests bound for Puxico can enjoy affordable comfort at Motel 6 Poplar Bluff MO, where relaxing rooms start at $75.46, providing a warm and inviting atmosphere perfect for unwinding. Cool off in the outdoor pools available at select Motel 6 locations, a perfect way to relax after a long day of travel.

From Motel 6 Poplar Bluff MO, a scenic drive takes guests into downtown Puxico, where they can explore the city's highlights before returning to the tranquility of the hotel. Book an inviting hotel that won’t break the bank for your Puxico visit—secure today!

  Call (855) 233-7850 to book with an agent.
  19.4 miles from Puxico, MO 63960

Starting at

$75.46

per night

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EC Reeds Mercantile&Hotel

301 1st St Marble Hill, MO

Choose EC Reeds Mercantile&Hotel for your visit to Puxico, where tucked away rooms provide comfort and quality at a welcoming rate of $116.99 per night. Relax in accommodations that are designed to offer both comfort and convenience, making your stay a pleasant one.

Step into relaxation at EC Reeds Mercantile&Hotel, a quiet retreat where you can explore Puxico's excitement whenever you choose. Get ready to experience Puxico like never before with a hotel that has it all—reserve now!

  Call (855) 234-5074 to book with an agent.
  26.0 miles from Puxico, MO 63960

Starting at

$116.99

per night

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Holiday Inn Express & Suites Sikeston Southwest an IHG Hotel

115 Hospitality Dr Sikeston, MO

Guests bound for Puxico will find intimate accommodations at Holiday Inn Express & Suites Sikeston Southwest an IHG Hotel, with rooms starting at $129.00, creating a clean and welcoming space perfect for relaxation. Take a break in Holiday Inn Express's comfortable seating areas, perfect for casual meetings, reading, or simply enjoying a moment of peace.

Discover the ideal retreat at Holiday Inn Express & Suites Sikeston Southwest an IHG Hotel, where restful nights meet the lively streets of Puxico just minutes away. Find the perfect base for exploring Puxico with affordable, inviting accommodations—secure now!

  Call (855) 236-8982 to book with an agent.
  32.5 miles from Puxico, MO 63960

Starting at

$129.00

per night

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Hampton Inn Sikeston

1240 Commerce Drive Sikeston, MO

Guests bound for Puxico will enjoy budget-conscious comfort at Hampton Inn Sikeston, with rooms starting at $112.99, creating a warm and inviting atmosphere. Make the most of Hampton's complimentary hot tea and coffee, available in the lobby all day, every day.

Whether for work or leisure, Hampton Inn Sikeston offers a balance of tranquility and easy access to Puxico's major attractions. Enjoy the convenience of a well-located, affordable hotel while visiting Puxico—book today!

  Call (855) 234-7135 to book with an agent.
  32.5 miles from Puxico, MO 63960

Starting at

$112.99

per night

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Super 8 by Wyndham Sikeston / Miner Area

2609 East Malone Ave Sikeston, MO

With rooms starting at $60.00, Super 8 by Wyndham Sikeston / Miner Area provides affordable comfort for guests visiting Puxico, creating a pleasant, inviting space ideal for relaxation and rest. Adjust to the perfect room climate with Super 8’s air conditioning, crucial for comfort during hot days or in tropical locations.

At Super 8 by Wyndham Sikeston / Miner Area, you can enjoy both restful accommodations and the easy access to Puxico's vibrant downtown area. Make your Puxico adventure budget-friendly and enjoyable—reserve your room now!

  Call (855) 235-0725 to book with an agent.
  34.4 miles from Puxico, MO 63960

Starting at

$60.00

per night

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Comfort Inn & Suites Sikeston I-55

109 Matthews Ln Sikeston, MO

For a restful stay near Puxico, Comfort Inn & Suites Sikeston I-55 offers relaxed accommodations with rooms from $87.99, creating a clean and comfortable environment perfect for relaxation. Discover each location's unique charm, with hotels designed to reflect their local environments and communities.

Experience a refreshing stay at Comfort Inn & Suites Sikeston I-55, where guests can unwind and still explore the vibrant life of Puxico. Take your Puxico trip to the next level with well-thought-out, budget-friendly lodging—lock in today!

  Call (855) 235-6136 to book with an agent.
  34.6 miles from Puxico, MO 63960

Starting at

$87.99

per night

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Travel Inn & Suites Sikeston / Miner (i-55 Exit 67)

100 Matthews Lane Sikeston, MO

For a budget-friendly stay, Travel Inn & Suites Sikeston / Miner (i-55 Exit 67) offers inviting rooms with rates beginning at $62.99, creating a clean and comfortable space near Puxico. Find an elevated stay experience in our rooms that combine practical amenities with a few extra touches for your comfort.

At Travel Inn & Suites Sikeston / Miner (i-55 Exit 67), you’ll find the perfect escape from city life, with Puxico's bustling attractions always just a short drive away. Choose a hotel that adds value to your Puxico experience—reserve your stay now!

  Call (855) 235-6136 to book with an agent.
  34.6 miles from Puxico, MO 63960

Starting at

$62.99

per night

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Best Western Plus Sikeston

120 South Interstate Drive Sikeston, MO

Guests bound for Puxico can enjoy inviting accommodations at Best Western Plus Sikeston, where rooms start at $76.99, creating a warm, welcoming environment for relaxation. Stay connected with friends and family using the complimentary postcard and mailing service available at Best Western Plus.

Enjoy a refreshing stay at Best Western Plus Sikeston, where the comfort of spacious rooms is matched by easy access to Puxico. Treat yourself to a Puxico stay that blends convenience with budget-friendly rates—book now!

  Call (855) 236-8982 to book with an agent.
  34.9 miles from Puxico, MO 63960

Starting at

$76.99

per night

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Country Yard Inn&Suite

110 South Interstate Drive Sikeston, MO

At Country Yard Inn&Suite, travelers to Puxico will find cushy rooms with rates beginning at $54.99, creating a warm, welcoming environment perfect for relaxation. Find comfort in rooms that are designed for affordability and practicality, offering the basics for a pleasant stay.

Step into relaxation at Country Yard Inn&Suite, a quiet retreat where you can explore Puxico's excitement whenever you choose. Book a welcoming, cost-effective hotel for your Puxico trip and save big—secure now!

  Call (855) 235-6136 to book with an agent.
  34.9 miles from Puxico, MO 63960

Starting at

$54.99

per night

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Days Inn&Suites by Wyndham Sikeston

220 South Interstate Dr Sikeston, MO

Guests bound for Puxico will appreciate the hospitable comfort at Days Inn&Suites by Wyndham Sikeston, where budget-friendly rooms start at $64.99, creating a warm and welcoming atmosphere. Relax in the assurance that Days Inn meets rigorous standards for cleanliness and guest satisfaction, providing a worry-free stay.

Find your escape at Days Inn&Suites by Wyndham Sikeston, offering the perfect blend of calm and proximity to the attractions of Puxico. Plan your Puxico trip with a welcoming, budget-friendly hotel—reserve your room today!

  Call (855) 233-7850 to book with an agent.
  34.9 miles from Puxico, MO 63960

Starting at

$64.99

per night

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Hampton Inn Cape Girardeau I 55 East

207 South Mt. Auburn Rd Cape Girardeau, MO

At Hampton Inn Cape Girardeau I 55 East, travelers to Puxico will find budget-friendly rooms with rates beginning at $113.99, creating a welcoming, serene space perfect for rest. Enjoy a unique stay at Hampton’s boutique properties, which offer a more personalized and intimate hotel experience.

Guests will appreciate the calm environment at Hampton Inn Cape Girardeau I 55 East, where restful lodgings are paired with quick access to Puxico. Treat yourself to an affordable, inviting hotel experience in Puxico—book today!

  Call (855) 234-7135 to book with an agent.
  39.7 miles from Puxico, MO 63960

Starting at

$113.99

per night

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Fairfield Inn & Suites by Marriott Cape Girardeau

433 CAPE WEST CROSSINGS Cape Girardeau, MO

For an affordable and soothing stay, Fairfield Inn & Suites by Marriott Cape Girardeau offers inviting rooms with rates beginning at $124.99, creating a welcoming and comfortable space for guests. Discover the joy of traveling with family at Fairfield, where children stay free when using existing bedding in the room.

Experience the tranquility of Fairfield Inn & Suites by Marriott Cape Girardeau, where guests can enjoy a restful stay while still being close to the attractions of Puxico. Step into Puxico comfort without the hefty price tag—lock in your hotel room today!

  Call (855) 239-4019 to book with an agent.
  39.9 miles from Puxico, MO 63960

Starting at

$124.99

per night

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Candlewood Suites Cape Girardeau an IHG Hotel

485 South Mount Auburn Rd Cape Girardeau, MO

At Candlewood Suites Cape Girardeau an IHG Hotel, guests bound for Puxico will find budget-friendly comfort with rooms starting at $103.00, creating a clean, welcoming space ideal for rest. Unwind in the privacy of Candlewood Suites' suites, featuring separate living and sleeping areas for your comfort and convenience.

Discover the best of both worlds at Candlewood Suites Cape Girardeau an IHG Hotel, where spacious rooms provide comfort and Puxico remains nearby for exploration. Get ready for a comfortable Puxico adventure with cost-effective, inviting accommodations—lock in now!

  Call (855) 233-7850 to book with an agent.
  39.9 miles from Puxico, MO 63960

Starting at

$103.00

per night

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Town House Inn

517 East Jackson Blvd Jackson, MO

With budget-friendly rooms starting at $59.99, Town House Inn provides inviting accommodations for travelers to Puxico, creating a gentle environment. Relax in accommodations that provide more than just the essentials, offering added comfort and convenience for a pleasant stay.

Enjoy the serene surroundings at Town House Inn, while keeping the culture and energy of Puxico nearby for your convenience. Plan your Puxico trip with a hotel that guarantees comfort and affordability—reserve today!

  Call (855) 235-0725 to book with an agent.
  40.0 miles from Puxico, MO 63960

Starting at

$59.99

per night

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