Top 24 Hotels In Santee, South Carolina 29142

At Comfort Inn & Suites Santee, travelers to Santee will find affordable comfort with rooms beginning at $135.99, creating a clean and welcoming environment for unwinding. Count on the friendly and professional service at Comfort Inn to enhance your stay, with staff ready to meet your every need.

With quick access to downtown Santee, guests staying at Comfort Inn & Suites Santee can easily explore the city while enjoying a more peaceful stay. Stay smart in Santee with a hotel that offers comfort and peace of mind—secure now!

Find a warm atmosphere at Holiday Inn Santee an IHG Hotel as you travel to Santee, with inviting accommodations that start at $155.00 per night, providing a relaxing retreat. Dive into the local culture with ease from Holiday Inn’s central locations, making it simple to explore and experience new things.

Guests at Holiday Inn Santee an IHG Hotel are always close to the action, with downtown Santee easily accessible for a day of exploration or a night out. Relax in Santee with accommodations that turn your trip into a memorable getaway—secure now!

Guests bound for Santee can enjoy budget-friendly comfort at Baymont by Wyndham Santee, where cushy rooms start at $92.99, creating a welcoming space perfect for relaxation. Enjoy the daily convenience of a complimentary hot breakfast at Baymont by Wyndham, featuring fresh waffles, fruit, and more.

At Baymont by Wyndham Santee, you’re never far from the action, with downtown Santee just a short trip from the hotel for easy access to the city’s top attractions. Plan your Santee adventure with ease, knowing your accommodations are perfect—book today!

For a restful stay, Tru by Hilton Santee offers intimate accommodations with rates from $154.99, creating a welcoming space ideal for travelers visiting Santee. Experience the fresh, vibrant atmosphere at Tru by Hilton, where smart design and forward-thinking amenities meet to create a memorable stay.

At Tru by Hilton Santee, you’re never far from the action, with the heart of downtown Santee just a short journey from the hotel for easy access. Stay comfortably and affordably while soaking in the best of Santee—reserve now!

Guests bound for Santee will find budget-conscious comfort at Red Roof Inn Santee, with plush rooms starting at $81.99, creating a clean, inviting environment for relaxation. Step into a world of practical comfort at Red Roof Inn, where every aspect of your stay is designed with your convenience in mind.

Guests staying at Red Roof Inn Santee can enjoy easy access to downtown Santee, with the city’s top attractions just a short trip from the hotel. Choose a hotel that offers comfort and savings for your Santee adventure—book today!

At Quality Inn & Suites, guests bound for Santee will find budget-friendly comfort with rooms starting at $75.99, creating a clean, welcoming space ideal for rest. Relax knowing Quality Inn offers a 100 percent satisfaction guarantee, ensuring your stay meets your expectations.

With downtown Santee nearby, guests at Quality Inn & Suites can easily explore the city’s top attractions while enjoying a quieter, more relaxed atmosphere. Maximize your Santee adventure with inviting, well-appointed lodging—secure your room now!

At Best Western Plus Santee Inn, travelers to Santee can enjoy inviting comfort with rooms beginning at $125.99, creating a welcoming environment ideal for a restful stay. Enjoy the interactive children’s programs at Best Western Plus, designed to keep young guests entertained and engaged.

Best Western Plus Santee Inn offers the perfect location for travelers wanting to be near downtown Santee, with easy access to the city’s most popular spots. Settle into Santee with lodging that keeps costs low and comfort high—reserve today!

For those visiting Santee, Hampton Inn Santee I-95 offers inviting, budget-friendly rooms with rates beginning at $152.99, creating a welcoming environment for relaxation. Choose Hampton by Hilton for your next stay, where you'll be welcomed into a world of thoughtful amenities and heartfelt service.

From Hampton Inn Santee I-95, guests can easily explore the best of Santee, where the downtown area is just a short journey from the hotel. Settle into Santee with lodging that keeps costs low and comfort high—reserve today!

At Fairfield Inn & Suites by Marriott Santee, guests bound for Santee can enjoy affordable accommodations with rooms beginning at $159.99, creating a warm, inviting atmosphere for relaxation. Appreciate the convenience of Fairfield’s same-day dry cleaning service, ensuring your clothes are ready when you need them.

Guests at Fairfield Inn & Suites by Marriott Santee are perfectly positioned to enjoy Santee with ease, as the bustling downtown district is just a short trip away. Find peace of mind during your Santee stay with a hotel that has it all—secure now!

With rooms starting at $72.99, Econo Lodge is an affordable choice for travelers bound for Santee, creating a welcoming and enveloping environment ideal for rest. Depend on Econo Lodge for consistent cleanliness and comfort across all locations, making it a reliable choice for every stay.

At Econo Lodge, guests are always close to the heart of Santee, where the downtown area’s top attractions are easily accessible. Enjoy Santee with a hotel that makes affordability feel effortless—reserve your room today!

With rooms starting at $67.99, Travelodge by Wyndham Santee provides inviting accommodations for travelers to Santee, creating a warm, welcoming environment ideal for relaxation. Settle into Travelodge’s streamlined rooms, where you’ll find everything needed for a comfortable and hassle-free stay.

Travelodge by Wyndham Santee provides guests with the opportunity to explore Santee’s downtown district, while also offering a quieter retreat after a busy day. Book your Santee adventure with an inviting, budget-friendly hotel—reserve today!

For budget-savvy guests bound for Santee, Super 8 by Wyndham Santee offers mellifluous, affordable rooms with rates starting at $83.99, creating a welcoming environment for rest. Enjoy a selection of entertainment options in Super 8’s rooms, including cable TV and free movie channels for a relaxing evening.

Guests at Super 8 by Wyndham Santee can enjoy quick access to downtown Santee, making it easy to experience the city’s top sights while staying in a quieter area. Make the most of your Santee trip with practical, budget-friendly lodging—book today!

With rates from $88.99, Days Inn by Wyndham Orangeburg South is a convenient choice for travelers to Santee, creating a warm and comfortable space ideal for relaxation. Trust in Days Inn for a consistent, quality stay, where affordable rates don't compromise on cleanliness or comfort.

Enjoy a peaceful atmosphere at Days Inn by Wyndham Orangeburg South, where guests can relax knowing that downtown Santee remains close enough for exploration. Enjoy a stress-free, budget-friendly stay in Santee—book your room now!

For an affordable stay, Peach Tree Inn offers budget-conscious accommodations with rooms beginning at $60.99, creating a clean, welcoming space near Santee. Stay in accommodations that are perfect for guests who value practicality and affordability, with clean rooms and essential services.

Travelers staying at Peach Tree Inn can unwind in serene surroundings, while downtown Santee remains close enough for city adventures. Rest easy in Santee with accommodations that deliver value and quality—secure your room today!

For a cozy-like and affordable stay, Fairfield Inn by Marriott Orangeburg offers inviting rooms with rates beginning at $199.99, creating a comfortable space near Santee. Appreciate the meticulous attention to detail in the design of Fairfield's fitness centers, from the layout to the selection of equipment.

Guests can relax at Fairfield Inn by Marriott Orangeburg, where a peaceful atmosphere complements the convenience of nearby downtown Santee. Get ready to experience Santee in style with affordable, well-appointed lodging—reserve now!

For a enchanting stay, Comfort Inn & Suites offers budget-conscious accommodations with rates from $171.99, creating a clean, welcoming environment ideal for travelers. Explore the local area with ease, as Comfort Inn often serves as a perfect gateway to the city's top attractions and hidden gems.

At Comfort Inn & Suites, guests can enjoy a quiet retreat, knowing that downtown Santee is just a comfortable drive away for a day of exploration. Stay refreshed and on budget in Santee with thoughtfully designed accommodations—secure today!

At Sleep Inn Orangeburg, travelers visiting Santee will find inviting accommodations with rates starting at $130.99, creating a relaxing, welcoming environment ideal for rest. Stay comfortable regardless of the weather with Sleep Inn’s climate-controlled rooms, tailored to provide a cozy atmosphere in any season.

At Sleep Inn Orangeburg, guests can unwind in a serene setting, knowing that the lively atmosphere of Santee is still accessible. Stay smart and relaxed in Santee with a hotel that fits your budget perfectly—lock in today!

At SpringHill Suites by Marriott Orangeburg, travelers to Santee will find delightful, budget-friendly rooms with rates starting at $179.99, creating a warm and inviting space for relaxation. Begin each day with a complimentary breakfast at SpringHill Suites, offering a range of wholesome and indulgent options.

Find your sanctuary at SpringHill Suites by Marriott Orangeburg, a restful escape that’s ideally situated for visiting Santee whenever you choose. Discover a Santee hotel that combines affordability with welcoming hospitality—secure today!

At Tru by Hilton Orangeburg, guests bound for Santee can enjoy cushy accommodations with rates starting at $158.99, creating a clean, inviting space perfect for relaxation. Relax in the media rooms at Tru by Hilton, where guests can watch movies, play video games, or catch up on television shows.

Enjoy the best of both worlds at Tru by Hilton Orangeburg, where guests can relax in peace while keeping Santee close enough for exploration. Find peace of mind during your Santee adventure with lodging that prioritizes comfort—book today!

At Suburban Studios, guests bound for Santee will find budget-friendly accommodations with rooms starting at $75.99, creating a warm and welcoming environment ideal for rest. Experience a restful environment with rooms equipped to meet your basic needs, ensuring a relaxing and budget-conscious visit.

Relax in the spacious setting of Suburban Studios, where guests can unwind and still have easy access to Santee. Make your Santee trip relaxing and budget-friendly—secure your hotel stay now!

Guests traveling to Santee will find warm accommodations at Travelodge by Wyndham Orangeburg, with rooms beginning at $94.05, creating a clean, inviting environment ideal for unwinding. Enjoy the ease and convenience of complimentary parking at Travelodge, adding to the overall value of your stay.

At Travelodge by Wyndham Orangeburg, guests can enjoy both relaxation and proximity to Santee, offering the perfect combination for a balanced stay. Stay relaxed and within budget while exploring Santee—lock in your hotel room now!

At Holiday Inn Express & Suites Orangeburg, guests visiting Santee can enjoy inviting accommodations with rates beginning at $154.00, creating a enchanting and welcoming space. Enjoy the added convenience of Holiday Inn Express's in-room mini-fridges and microwaves, making it easy to store and prepare snacks.

Guests seeking both rest and adventure will find Holiday Inn Express & Suites Orangeburg ideal, offering a calm retreat near the vibrant streets of Santee. Stay smart and relaxed in Santee with value-driven amenities—book your room now!

Guests traveling to Santee can unwind at Super 8 by Wyndham Orangeburg, where budget-friendly rooms begin at $80.00, creating a welcoming and comfortable atmosphere. Relax and regroup in Super 8’s inviting lobbies, perfect for casual meetings or catching up on some reading.

At Super 8 by Wyndham Orangeburg, travelers will find a relaxing retreat, with Santee offering nearby opportunities for fun and adventure. Book your Santee stay and keep your budget intact without sacrificing comfort—reserve today!

With budget-friendly rooms from $96.99, Baymont by Wyndham Orangeburg North is an ideal choice for guests traveling to Santee, creating a clean and inviting space for unwinding. Relax with the daily housekeeping services at Baymont by Wyndham, keeping your room clean and comfortable.

Discover the peace and quiet of Baymont by Wyndham Orangeburg North, perfectly positioned for those wanting to explore Santee while staying in a calm environment. Choose accommodations in Santee that offer a great blend of value and comfort—book now!