Top 24 Hotels In Sereno, Missouri 63775

For those bound for Sereno, Days Inn by Wyndham Perryville offers inviting, budget-friendly accommodations with rooms beginning at $70.00, creating a welcoming space for all guests. Stay fit with Days Inn's gym facilities, where you can keep up with your fitness routine while on the road.

The serene environment at Days Inn by Wyndham Perryville offers guests a quiet place to relax, with downtown Sereno still within easy driving distance for sightseeing. Plan your Sereno visit wisely with budget-friendly, inviting accommodations—book now!

Guests bound for Sereno will appreciate the delightful accommodations at Super 8 by Wyndham Perryville, with rates beginning at $74.99, creating a clean and welcoming space for relaxation. Take advantage of Super 8's ample parking, accommodating guests with vehicles and making road trips hassle-free.

A short drive from Super 8 by Wyndham Perryville takes guests into downtown Sereno, where they can experience the city’s highlights before retreating to a quiet stay. Plan your Sereno adventure with comfort and affordability in mind—book now!

For travelers headed to Sereno, Quality Inn offers inviting rooms with rates starting at $71.00, creating a clean and welcoming environment perfect for relaxation. Experience attentive service with Quality Inn's concierge team, ready to assist with reservations, transportation, and personal requests.

Guests staying at Quality Inn will love the balance of easy city access and the quiet surroundings of the hotel, perfect for a peaceful retreat. Enjoy the convenience of well-situated, cost-effective lodging in Sereno—book today!

Guests headed to Sereno will find harmonious accommodations at Holiday Inn Express & Suites Perryville an IHG Hotel, where rooms begin at $119.00, creating a warm and welcoming environment ideal for rest. Stay refreshed with Holiday Inn Express's indoor or outdoor swimming pools, providing a relaxing escape or a fun family activity.

With downtown Sereno a quick drive away, guests at Holiday Inn Express & Suites Perryville an IHG Hotel can balance city exploration with the hotel’s serene atmosphere. Find peace of mind during your Sereno stay with a hotel that has it all—secure now!

Guests visiting Sereno will find inviting comfort at Baymont by Wyndham Chester IL, where inviting rooms start at $89.99, creating a welcoming space perfect for relaxation. Relax in the comfort of Baymont by Wyndham's rooms, where thoughtful amenities meet homely charm to provide a restful experience.

From Baymont by Wyndham Chester IL, a quick drive brings guests into downtown Sereno, where they can explore the city’s best spots and return to a quiet retreat. Treat yourself to an affordable, inviting hotel experience in Sereno—book today!

For an affordable and restful stay near Sereno, Microtel Inn & Suites by Wyndham Sainte Genevieve offers budget-friendly accommodations with rooms starting at $87.99, creating a welcoming space. Consider Microtel Inn & Suites by Wyndham for an enjoyable, budget-friendly stay without compromising on comfort or quality.

For a relaxing getaway, Microtel Inn & Suites by Wyndham Sainte Genevieve provides calm surroundings while keeping downtown Sereno within easy reach for exploration. Plan your perfect Sereno getaway with a hotel that has your comfort and savings in mind—book today!

With rooms starting at $123.00, Holiday Inn Express Hotel & Suites Sparta an IHG Hotel provides inviting accommodations for guests bound for Sereno, creating a cozy-like, comfortable environment ideal for relaxation. Experience the festive atmosphere during the holidays at Holiday Inn Express, with special decorations and seasonal offerings.

Stay at Holiday Inn Express Hotel & Suites Sparta an IHG Hotel to experience the perfect blend of quiet nights and quick trips into Sereno's lively streets. Get ready for a Sereno visit with a hotel that makes relaxation effortless—lock in today!

Guests bound for Sereno can enjoy budget-friendly comfort at Holiday Inn Express & Suites Murphysboro Carbondale an IHG Hotel, where heartwarming rooms start at $124.00, creating a welcoming space perfect for relaxation. Experience the reliability of Holiday Inn Express's wake-up service, ensuring you start your day on time.

Stay at Holiday Inn Express & Suites Murphysboro Carbondale an IHG Hotel for a quiet retreat, where the calm environment is matched by quick access to Sereno's activities. Get ready for a memorable Sereno trip with lodging that puts you first—secure now!

For an inviting and budget-conscious stay near Sereno, Madison Inn Lodge offers soft rooms with rates beginning at $81.00, creating a welcoming atmosphere for rest. Enjoy a comfortable and welcoming environment in rooms that provide additional amenities for a relaxing visit.

At Madison Inn Lodge, you can enjoy the balance of a quiet stay while keeping Sereno just a short drive away. Discover the ideal way to visit Sereno with a hotel that values your comfort—secure now!

For a welcoming and budget-friendly stay, Town House Inn offers inviting rooms with rates from $59.99, creating a calm space ideal for travelers bound for Sereno. Stay in accommodations that enhance your experience with added comforts and conveniences, all at an economical price.

Unwind in the tranquil surroundings of Town House Inn, where a restful stay is paired with convenient access to Sereno. Discover a hotel that keeps your Sereno visit affordable and comfortable—book your room now!

For budget-conscious travelers headed to Sereno, Hampton Inn Farmington offers comfortable rooms starting at $173.99, creating a clean and inviting atmosphere. Utilize Hampton’s laundry services during longer stays, keeping your wardrobe fresh and ready for whatever your trip entails.

Experience the tranquility of Hampton Inn Farmington, where guests can enjoy a restful stay while still being close to the attractions of Sereno. Find peace of mind during your Sereno adventure with lodging that prioritizes comfort—book today!

Guests visiting Sereno will find inviting comfort at Holiday Inn Express & Suites Farmington an IHG Hotel, where alluring rooms start at $199.00, creating a welcoming space perfect for relaxation. Relax in the outdoor hot tubs available at select Holiday Inn Express locations, a perfect way to unwind.

Experience the comfort of Holiday Inn Express & Suites Farmington an IHG Hotel, where a calm retreat is balanced by the easy reach of Sereno’s top destinations. Experience a stress-free Sereno visit with accommodations that enhance your stay—reserve today!

Guests visiting Sereno will find Super 8 by Wyndham Farmington a tucked away, budget-friendly option, with rates starting at $57.00, creating a clean and inviting environment. Benefit from ample and secure parking at Super 8, accommodating all types of vehicles with ease during your road trip.

Nestled outside the city’s core, Super 8 by Wyndham Farmington provides a great option for those seeking tranquility near Sereno. Plan your Sereno getaway with a hotel that offers great value—lock in now!

With budget-friendly rooms from $57.99, Baymont Inn&Suites by Wyndham Farmington MO is ideal for travelers visiting Sereno, creating a warm and inviting environment for relaxation. Enjoy the added convenience of Baymont by Wyndham’s express checkout service, allowing for a quick and easy departure.

Unwind in comfort at Baymont Inn&Suites by Wyndham Farmington MO, where guests can rest in quiet surroundings and still enjoy the convenience of Sereno. Stay comfortably and affordably in Sereno with accommodations that deliver—book now!

Guests bound for Sereno can enjoy inviting accommodations at Quality Inn Farmington, where rooms start at $54.00, creating a warm, welcoming environment for relaxation. Start your day strong with Quality Inn's complimentary hot breakfast, offering everything from eggs and waffles to healthy options.

Step into the calm of Quality Inn Farmington, where restful lodgings are paired with proximity to Sereno's vibrant streets. Experience Sereno with peace of mind, knowing your hotel delivers value—secure now!

With rooms beginning at $117.99, Crown Pointe Lodge Best Western Signature Collection is a practical choice for travelers visiting Sereno, creating a hospitable and comfortable space ideal for rest. Get a great night's sleep on Best Western's premium mattresses, designed for comfort and support.

Guests seeking both rest and adventure will find Crown Pointe Lodge Best Western Signature Collection ideal, offering a calm retreat near the vibrant streets of Sereno. Find the perfect place to rest after exploring Sereno with budget-friendly lodging—secure today!

Guests traveling to Sereno will appreciate the inviting accommodations at University Inn of Carbondale, with budget-friendly rooms starting at $65.00, creating a clean, comfortable atmosphere. Find efficiency and comfort in rooms that are designed with the budget traveler in mind, offering basic amenities and a clean setting.

Escape the crowds at University Inn of Carbondale, where you can enjoy quiet comfort while keeping Sereno's attractions within easy reach. Unwind in Sereno at a hotel that provides comfort and value in every way—reserve today!

At Comfort Suites Jackson Cape Girardeau, guests bound for Sereno will find budget-friendly comfort with rooms starting at $89.40, creating a clean, welcoming space ideal for rest. Take a culinary journey with Comfort Suites' themed dinner nights, featuring cuisines from around the world.

At Comfort Suites Jackson Cape Girardeau, you’ll find the balance between relaxation and proximity to Sereno, making it an ideal base for exploration. Choose a hotel that makes your Sereno experience seamless and budget-wise—reserve now!

Guests bound for Sereno will enjoy budget-conscious comfort at La Quinta Inn & Suites by Wyndham Jackson / Cape Girardeau, with rooms starting at $79.99, creating a warm and inviting atmosphere. Relax in the knowledge that La Quinta offers a satisfaction guarantee, ensuring your stay meets all your expectations.

At La Quinta Inn & Suites by Wyndham Jackson / Cape Girardeau, guests are treated to restful accommodations with the advantage of being close to Sereno's top destinations. Choose a hotel that adds value to your Sereno journey—lock in your room now!

With rooms starting at $87.99, Roseners Inn&banquet center is a practical choice for travelers headed to Sereno, providing a clean, inviting space for relaxation. Relax in accommodations that deliver practical comfort, making your stay both convenient and budget-friendly.

Travelers will love the serene setting at Roseners Inn&banquet center, where peaceful accommodations offer a relaxing stay near Sereno. Enjoy reliable, comfortable lodging that fits your budget in Sereno—secure now!

Enjoy a calm stay at Home2 Suites by Hilton Carbondale near Sereno, where quality accommodations provide warmth and relaxation, with inviting rates from $158.99 per night. Stay connected with Home2 Suites' multi-device Wi-Fi, allowing you to connect all your devices without hassle.

Unwind in the spacious comfort of Home2 Suites by Hilton Carbondale, where guests can relax while keeping Sereno within reach. Discover a worry-free Sereno stay with a hotel that keeps your comfort front and center—secure now!

Guests bound for Sereno can enjoy cushy comfort at Quality Inn, where rooms start at $61.00, creating a welcoming environment ideal for relaxation. Stay energized with Quality Inn's complimentary coffee stations, available 24/7 in the lobby for a quick pick-me-up.

Unwind in comfort at Quality Inn, where guests are treated to peaceful surroundings with Sereno's highlights just a short trip away. Make your Sereno visit memorable and stress-free with inviting amenities—lock in today!

Stay comfortably at EC Reeds Mercantile&Hotel on your trip to Sereno, where calm rooms create a welcoming experience, with budget-friendly rates starting at $116.99. Stay in accommodations that provide a delightful mix of modern amenities and traditional comfort.

Relax at EC Reeds Mercantile&Hotel, where a peaceful retreat is enhanced by the convenience of Sereno’s nearby attractions. Plan your Sereno getaway with accommodations that make every moment enjoyable—secure now!

With rooms beginning at $91.99, Fairgrounds Inn offers appealing accommodations for guests traveling to Sereno, creating a clean and welcoming space for relaxation. Relax in accommodations that deliver standard amenities, offering a comfortable environment for a budget-friendly visit.

At Fairgrounds Inn, the peaceful atmosphere offers guests a restful stay while keeping the attractions of Sereno close by. Plan your Sereno trip with a welcoming, budget-friendly hotel—reserve your room today!