Top 24 Hotels In St. Leo, Florida 33525

At Hampton Inn Dade City Zephyrhills, travelers bound for St. Leo can enjoy safe accommodations with rooms starting at $137.99, creating a clean and comfortable space perfect for rest. Experience the warmth of Hampton's community-focused approach, with inviting public spaces designed to bring guests together.

With downtown St. Leo just a short drive from Hampton Inn Dade City Zephyrhills, guests can explore the city’s most exciting attractions while staying in a more relaxed area. Treat yourself to a St. Leo stay that blends convenience with budget-friendly rates—book now!

For an affordable and welcoming stay, Microtel Inn & Suites by Wyndham Zephyrhills offers budget-friendly rooms with rates from $122.99, creating a comfortable space perfect for guests bound for St. Leo. Find our locations perfectly placed near airports and major attractions, making Microtel an ideal choice for both leisure and business.

From Microtel Inn & Suites by Wyndham Zephyrhills, a convenient drive brings guests into downtown St. Leo, where they can enjoy the city’s attractions and return to a quiet stay. Make your St. Leo trip enjoyable and cost-effective—lock in your hotel stay now!

For a serene and comfortable stay, Roadstar Hotel Zephyrhills offers budget-friendly accommodations with rooms from $102.99, providing a clean, inviting space near St. Leo. Stay in a room that offers practical comfort and essential amenities, ensuring a pleasant and affordable visit.

From Roadstar Hotel Zephyrhills, a simple drive brings guests into downtown St. Leo, where they can explore the city’s top attractions and return to a quiet setting. Stay relaxed and enjoy more of St. Leo with budget-friendly comfort—reserve today!

Those visiting St. Leo will revel in the upscale charm of Saddlebrook Golf Resort & Spa Tampa North Wesley Chapel, where inviting accommodations promise elegance, with nightly rates starting at $159.20. Enjoy a stay characterized by sophistication and luxury, where rooms are designed to offer an unparalleled level of comfort.

The tranquility of Saddlebrook Golf Resort & Spa Tampa North Wesley Chapel provides a calm retreat, with the excitement of downtown St. Leo still within reach for a day of exploration. Take advantage of a St. Leo hotel that knows how to make every moment remarkable—book today!

Encounter a restful stay at SPOT X Hotel Tampa Wesley Chapel by The Red Collection near St. Leo, where quality rooms offer comfort and relaxation, with inviting rates beginning at just $154.00. Stay in accommodations that provide a delightful mix of modern amenities and traditional comfort.

The serene location of SPOT X Hotel Tampa Wesley Chapel by The Red Collection provides a restful retreat, while downtown St. Leo is still accessible by car for those wanting to explore the city. Get ready for a memorable St. Leo stay with a hotel that delivers on both value and comfort—secure now!

With budget-friendly rooms beginning at $149.00, Best Western Wesley Chapel provides comfortable accommodations for travelers to St. Leo, creating a welcoming environment for rest. Take advantage of Best Western’s seasonal offers, providing special rates and packages that align with local festivals and events.

The relaxing atmosphere of Best Western Wesley Chapel offers guests a calm retreat, with downtown St. Leo still just a drive away for all their sightseeing needs. Stay affordably and enjoy the best of St. Leo with a hotel that understands your needs—lock in today!

At Econo Lodge, guests visiting St. Leo will find affordable comfort with rooms beginning at $109.99, creating a warm and inviting space perfect for unwinding. Start your day energized with Econo Lodge’s complimentary breakfast, providing a variety of options to suit different tastes and preferences.

At Econo Lodge, visitors can enjoy the balance of being near downtown St. Leo while staying in a quieter, more peaceful location. Make your St. Leo travels relaxing and budget-smart—reserve your hotel today!

Choose Residence Inn by Marriott Tampa Wesley Chapel near St. Leo for a delightful balance of quality and affordability, where inviting rooms provide comfort at a starting rate of $159.99 per night. Relax and unwind at Residence Inn, where you'll find spacious accommodations and friendly service to make your stay a pleasant one.

Rest easy at Residence Inn by Marriott Tampa Wesley Chapel, where calm surroundings create a restful stay, and downtown St. Leo is still within driving distance. Take the stress out of St. Leo travel with a hotel that ensures a seamless stay—secure now!

With rooms beginning at $159.99, Fairfield Inn & Suites by Marriott Tampa Wesley Chapel provides budget-friendly accommodations for travelers visiting St. Leo, creating a warm and welcoming environment. Savor the moment with Fairfield's thoughtful touches, from freshly baked cookies in the lobby to personalized greetings upon check-in.

At Fairfield Inn & Suites by Marriott Tampa Wesley Chapel, guests can unwind in a serene environment, knowing that downtown St. Leo is just a comfortable drive away. Experience St. Leo with a hotel that balances convenience and affordability perfectly—reserve now!

Stay at Holiday Inn Express & Suites Tampa North Wesley Chapel an IHG Hotel when traveling to St. Leo, where inviting rooms create a snug retreat, with rates starting at a welcoming $201.99 per night. Opt for Holiday Inn Express, where straightforward amenities and efficient service ensure a smooth and comfortable travel experience.

Guests staying at Holiday Inn Express & Suites Tampa North Wesley Chapel an IHG Hotel can unwind in a peaceful retreat, with downtown St. Leo still close enough for a day of city exploration. Enjoy every aspect of your St. Leo trip with a hotel that delivers on quality—secure now!

For an affordable and inviting stay, WoodSpring Suites Wesley Chapel Tampa offers comforting rooms with rates from $129.99, creating a clean, comfortable atmosphere perfect for travelers. Appreciate the personal attention from the staff at WoodSpring Suites, who strive to make your extended stay as enjoyable as possible.

A peaceful stay awaits at WoodSpring Suites Wesley Chapel Tampa, where the quiet atmosphere creates a relaxing retreat and downtown St. Leo is nearby. Discover how stress-free St. Leo can be with well-appointed, affordable lodging—book today!

For an inviting and comfortable stay near St. Leo, Hampton Inn & Suites Tampa Wesley Chapel offers budget-friendly rooms with rates beginning at $140.99, creating a warm space. Celebrate at Hampton with available spaces for events, providing everything you need for meetings, parties, or gatherings.

Unwind in the peaceful surroundings of Hampton Inn & Suites Tampa Wesley Chapel, while knowing that downtown St. Leo is still within reach for sightseeing and exploration. Get the most out of your St. Leo visit with lodging that makes sense—lock in today!

Relax in the inviting surroundings of Hyatt Place Tampa / Wesley Chapel on your journey to St. Leo, where quality rooms offer comfort and value, with starting rates at $148.99 per night. Embrace Hyatt Place's eco-friendly initiatives, which focus on sustainability and responsible living without compromising on comfort.

The calm environment at Hyatt Place Tampa / Wesley Chapel creates a peaceful escape, with downtown St. Leo close enough for all your adventures. Rest and rejuvenate in St. Leo with a hotel that caters to your every need—lock in today!

Relax in style at Hilton Garden Inn Tampa Wesley Chapel FL on your journey to St. Leo, where quality rooms provide comfort and value, with affordable nightly rates from $142.99. Support sustainability with Hilton Garden Inn’s eco-friendly initiatives, designed to reduce environmental impact while maintaining comfort.

Rest in the serene setting of Hilton Garden Inn Tampa Wesley Chapel FL, while downtown St. Leo remains close enough for easy access to city attractions. Enjoy added value and luxury in St. Leo without the hefty price tag—reserve now!

For budget-savvy travelers to St. Leo, Microtel Inn & Suites by Wyndham Brooksville offers inviting accommodations with rooms from $110.99, creating a warm, comfortable environment for rest. Benefit from the smart layout of Microtel's suites, designed to maximize space and comfort for all types of travelers.

Relax in the peaceful surroundings of Microtel Inn & Suites by Wyndham Brooksville, where guests can rest while downtown St. Leo remains nearby for adventure. Book an inviting, cost-conscious hotel for your St. Leo adventure—lock in today!

At Holiday Inn Express Hotel & Suites Brooksville an IHG Hotel, guests bound for St. Leo will find budget-friendly comfort with rooms starting at $184.00, creating a clean, welcoming space ideal for rest. Stay connected with free high-speed Wi-Fi at Holiday Inn Express, making it easy to work or keep in touch while on the go.

Rest easy at Holiday Inn Express Hotel & Suites Brooksville an IHG Hotel, enjoying quiet surroundings while still being within a convenient drive of downtown St. Leo for exploration. Plan your St. Leo trip with ease, knowing your hotel offers comfort at a great rate—book now!

With budget-friendly rooms from $97.99, Quality Inn & Suites Brooksville I-75 / Dade City provides intimate accommodations for travelers bound for St. Leo, creating a warm, welcoming space. Step into Quality Inn, where value meets comfort, ensuring a satisfying stay for every guest.

Unwind at Quality Inn & Suites Brooksville I-75 / Dade City, where peaceful surroundings set the tone for a restful stay, and downtown St. Leo remains a short drive away. Get the most out of your St. Leo visit with lodging that makes sense—lock in today!

With rooms starting at $111.99, Days Inn by Wyndham Brooksville / Dade City provides affordable accommodations for travelers bound for St. Leo, creating a warm and welcoming atmosphere for relaxation. Relax with a peace of mind provided by our round-the-clock security measures, ensuring a safe environment for all guests.

From Days Inn by Wyndham Brooksville / Dade City, a relaxing drive brings guests into the heart of St. Leo, offering the perfect balance between city exploration and tranquility. Lock in budget-friendly comfort for your St. Leo adventure—book your room now!

At La Quinta Inn & Suites by Wyndham Tampa North I-75, travelers bound for St. Leo will find budget-conscious accommodations with rooms starting at $196.99, creating a warm, welcoming environment. Wake up on the bright side with La Quinta's complimentary Bright Side Breakfast®, offering a delicious variety of hot and cold options.

Unwind at La Quinta Inn & Suites by Wyndham Tampa North I-75, where quiet surroundings make for a restful stay and downtown St. Leo remains nearby for adventure. Experience St. Leo with ease by booking a hotel that makes value a priority—lock in now!

At SpringHill Suites by Marriott Tampa North / I 75 Tampa Palms, guests visiting St. Leo can find a balance of comfort and affordability, with inviting rooms available from a welcoming $204.99 per night. Stay fit on the road with SpringHill Suites' well-equipped fitness centers, offering cardio equipment and free weights.

Guests staying at SpringHill Suites by Marriott Tampa North / I 75 Tampa Palms can enjoy a quiet retreat, with downtown St. Leo still within reach for all their city adventures. Discover how extraordinary your St. Leo adventure can be with thoughtfully appointed lodging—reserve now!

With rooms beginning at $107.99, Extended Stay America Select Suites Tampa N USF Attractions is a practical choice for travelers visiting St. Leo, creating a warm and comfortable space ideal for rest. Stay healthy with Extended Stay America’s non-smoking rooms, ensuring a clean and fresh environment during your stay.

At Extended Stay America Select Suites Tampa N USF Attractions, visitors can unwind in peaceful surroundings, knowing that downtown St. Leo is still within reach for a day of adventure. Relax and recharge in St. Leo with a hotel that keeps your wallet happy—book today!

Guests bound for St. Leo can unwind at Fairfield Inn & Suites by Marriott Tampa North, where peaceful rooms start at $184.99, creating a warm and inviting environment perfect for relaxation. Make the most of your travels with Fairfield by Marriott's loyalty program, earning rewards and enjoying exclusive benefits as a member.

The calm environment at Fairfield Inn & Suites by Marriott Tampa North creates a peaceful escape, with downtown St. Leo close enough for all your adventures. Take the guesswork out of your St. Leo stay with a hotel that delivers on value—secure now!

For those visiting St. Leo, Extended Stay America Suites Tampa Northeast offers inviting, budget-friendly rooms with rates beginning at $107.99, creating a welcoming environment for relaxation. Experience the convenience of dining discounts provided by Extended Stay America, offering savings at nearby restaurants.

With a smooth drive into downtown St. Leo, guests at Extended Stay America Suites Tampa Northeast can enjoy the city’s highlights while retreating to the hotel’s quiet atmosphere. Find the perfect base for your St. Leo adventure with lodging that fits your budget—secure now!

At Hampton Inn & Suites Tampa North, travelers to St. Leo will find budget-friendly rooms with rates starting at $166.99, creating a clean, welcoming environment perfect for rest. Check in effortlessly with Hampton's streamlined online process, ensuring you can bypass the front desk and head straight to your room.

Guests staying at Hampton Inn & Suites Tampa North will enjoy a peaceful atmosphere, with downtown St. Leo remaining nearby for exploration. Discover how great your St. Leo stay can be with thoughtful, cost-effective amenities—secure now!