The best deals on hotels when visiting Syracuse in South Carolina.

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Top 24 Hotels In Syracuse, South Carolina 29532

Raceway Inn

705 Washington St Darlington, SC

At Raceway Inn, guests bound for Syracuse can enjoy appealing accommodations with rates starting at $60.99, creating a clean, inviting space perfect for relaxation. Stay in rooms that provide a perfect blend of comfort and convenience, designed to enhance your experience at an affordable rate.

At Raceway Inn, guests can enjoy a relaxing stay while having the convenience of downtown Syracuse within easy driving distance. Enjoy more of Syracuse with a practical hotel designed for your convenience—reserve now!

  Call (855) 234-5074 to book with an agent.
  6.3 miles from Syracuse, SC 29532

Starting at

$60.99

per night

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Homewood Suites by Hilton Florence

3450 West Radio Drive Florence, SC

Experience quality and comfort at Homewood Suites by Hilton Florence as you explore Syracuse, where restful rooms create a welcoming atmosphere, with rates starting from $156.99. Relish the spacious suite designs at Homewood Suites, offering a seamless blend of style and functionality for longer stays.

From Homewood Suites by Hilton Florence, guests can drive into downtown Syracuse, where they can explore the city’s most popular spots before retreating to a peaceful stay. Experience the best of Syracuse with accommodations that add value to your adventure—reserve now!

  Call (855) 234-2997 to book with an agent.
  7.6 miles from Syracuse, SC 29532

Starting at

$156.99

per night

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Super 8 by Wyndham Florence SC I-95 North / Hwy 76

3783A West Palmetto Street Florence, SC

At Super 8 by Wyndham Florence SC I-95 North / Hwy 76, guests visiting Syracuse can enjoy affordable comfort with rooms starting at $50.99, providing a welcoming and comfortable environment. Breathe easy in Super 8’s smoke-free rooms, promoting a clean and healthy environment for all guests.

With Syracuse still within reach, guests at Super 8 by Wyndham Florence SC I-95 North / Hwy 76 can explore the city’s most vibrant spots during the day and return to a more relaxed stay at night. Enjoy more of Syracuse for less with budget-friendly, inviting hotel rooms—book now!

  Call (855) 235-6136 to book with an agent.
  7.6 miles from Syracuse, SC 29532

Starting at

$50.99

per night

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Staybridge Suites Florence Civic Center an IHG Hotel

150 Westpark Drive Florence, SC

Relax at Staybridge Suites Florence Civic Center an IHG Hotel as you explore Syracuse, where quality rooms provide a peaceful stay, with budget-friendly nightly rates from $191.96. Relax with Staybridge Suites' in-room massage services, available by appointment for an added touch of luxury.

With a convenient drive into downtown Syracuse, guests at Staybridge Suites Florence Civic Center an IHG Hotel can balance city adventures with a quieter, more peaceful stay. Uncover a Syracuse stay that makes you feel relaxed and well cared for—secure now!

  Call (855) 234-5074 to book with an agent.
  7.7 miles from Syracuse, SC 29532

Starting at

$191.96

per night

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Holiday Inn Express & Suites Florence I-95 & I-20 Civic Center an IHG Hotel

3440 West Radio Dr Florence, SC

Guests traveling to Syracuse will find enchanting comfort at Holiday Inn Express & Suites Florence I-95 & I-20 Civic Center an IHG Hotel, with budget-friendly rooms starting at $144.00, creating a warm and inviting space perfect for rest. Benefit from Holiday Inn Express's ample free parking, making it easy to come and go as you please.

From Holiday Inn Express & Suites Florence I-95 & I-20 Civic Center an IHG Hotel, the drive into downtown Syracuse is straightforward, allowing guests to explore the city’s top destinations while returning to a peaceful setting afterward. Treat yourself to a Syracuse adventure where comfort and affordability go hand in hand—reserve now!

  Call (855) 233-0132 to book with an agent.
  7.7 miles from Syracuse, SC 29532

Starting at

$144.00

per night

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Quality Inn&Suites Civic

150 Dunbarton Dr Florence, SC

With rates beginning at $95.99, Quality Inn&Suites Civic is a smart choice for travelers to Syracuse, creating a warm-hearted space perfect for rest and relaxation. Discover dining and entertainment just steps away from Quality Inn, thanks to its prime locations in vibrant neighborhoods.

At Quality Inn&Suites Civic, guests can balance the excitement of city exploration with the calm of their stay, as downtown Syracuse is just a drive away. Revel in added perks and comfort for your Syracuse stay without breaking the bank—lock in today!

  Call (855) 233-0132 to book with an agent.
  7.8 miles from Syracuse, SC 29532

Starting at

$95.99

per night

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Days Inn by Wyndham Florence Near Civic Center

140 Dunbarton Dr Florence, SC

With rates beginning at $77.99, Days Inn by Wyndham Florence Near Civic Center is an ideal choice for budget-savvy travelers to Syracuse, creating a warm and inviting space. Experience the convenience of Days Inn's on-site dining options, serving delicious meals and snacks throughout the day.

From Days Inn by Wyndham Florence Near Civic Center, a short drive delivers guests into downtown Syracuse, where they can explore the city’s top attractions and return to a restful stay. Enjoy the convenience of well-situated, cost-effective lodging in Syracuse—book today!

  Call (855) 235-6136 to book with an agent.
  7.8 miles from Syracuse, SC 29532

Starting at

$77.99

per night

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Home2 Suites by Hilton Florence SC

900 Woody Jones Blvd Florence, SC

Choose Home2 Suites by Hilton Florence SC for your visit to Syracuse, where welcoming accommodations offer comfort and relaxation, with affordable room rates starting at $138.99. Appreciate the modern and stylish design of Home2 Suites' accommodations, offering a fresh and inviting atmosphere.

With a drive into downtown Syracuse, guests at Home2 Suites by Hilton Florence SC can enjoy the city’s top attractions without sacrificing the quiet and calm of their stay. Plan an unforgettable Syracuse adventure with a hotel that makes every moment count—reserve now!

  Call (855) 234-2997 to book with an agent.
  7.9 miles from Syracuse, SC 29532

Starting at

$138.99

per night

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Hampton Inn & Suites Florence Center

3000 West Radio Dr Florence, SC

For budget-savvy travelers, Hampton Inn & Suites Florence Center provides relaxing accommodations with rates beginning at $151.99, creating a clean and comfortable space near Syracuse. Kickstart your day with a premium coffee from Hampton’s select coffee brands, ensuring a high-quality brew to wake you up right.

From Hampton Inn & Suites Florence Center, a brief drive takes guests into downtown Syracuse, where they can experience the city’s highlights and return to a peaceful stay afterward. Choose a hotel that complements your Syracuse plans with ease and affordability—secure now!

  Call (855) 234-2997 to book with an agent.
  8.0 miles from Syracuse, SC 29532

Starting at

$151.99

per night

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Aloft Florence

820 WOODY JONES BOULEVARD Florence, SC

Choose Aloft Florence for a peaceful visit to Syracuse, where restful rooms provide warmth and relaxation, with inviting rates beginning at $154.99 per night. Host dynamic meetings in Aloft's adaptable conference spaces, equipped with the latest technology for successful events.

With a drive into downtown Syracuse, guests at Aloft Florence can enjoy the city’s top attractions without sacrificing the quiet and calm of their stay. Step into your Syracuse travels with a hotel that makes your stay effortless—book today!

  Call (855) 234-5074 to book with an agent.
  8.0 miles from Syracuse, SC 29532

Starting at

$154.99

per night

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Comfort Inn & Suites

527 Woody Jones Blvd Florence, SC

With rates from $128.99, Comfort Inn & Suites is ideal for travelers bound for Syracuse, providing delightful, budget-friendly accommodations perfect for relaxation. Appreciate the modern amenities and services at Comfort Inn, designed to meet the needs of today's travelers.

From Comfort Inn & Suites, a convenient drive delivers guests to downtown Syracuse, where they can enjoy the city’s highlights before returning to a peaceful retreat. Enjoy a seamless Syracuse experience with well-rounded, budget-savvy lodging—book today!

  Call (855) 233-0132 to book with an agent.
  8.1 miles from Syracuse, SC 29532

Starting at

$128.99

per night

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SpringHill Suites by Marriott Florence

2670 Hospitality Blvd Florence, SC

Uncover a restful stay at SpringHill Suites by Marriott Florence near Syracuse, where quality rooms offer comfort and relaxation, with inviting rates beginning at just $152.99. Begin each day with a complimentary breakfast at SpringHill Suites, offering a range of wholesome and indulgent options.

At SpringHill Suites by Marriott Florence, visitors can unwind in the peaceful surroundings of the hotel, while downtown Syracuse remains within easy reach for exploration. Enjoy a Syracuse adventure with a hotel that’s committed to your satisfaction—book today!

  Call (855) 239-4019 to book with an agent.
  8.1 miles from Syracuse, SC 29532

Starting at

$152.99

per night

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Courtyard by Marriott Florence

2680 Hospitality Blvd Florence, SC

Discover intimate accommodations at Courtyard by Marriott Florence as you visit Syracuse, where inviting rooms create a warm ambiance, with affordable rates beginning at $149.99. Receive personalized attention from Courtyard's guest experience managers, dedicated to ensuring your stay is as enjoyable as possible.

With a short drive into downtown Syracuse, guests at Courtyard by Marriott Florence can explore the city’s highlights and return to the hotel’s peaceful atmosphere. Stay in Syracuse with a hotel that promises comfort, style, and budget-friendly rates—book today!

  Call (855) 234-2997 to book with an agent.
  8.1 miles from Syracuse, SC 29532

Starting at

$149.99

per night

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Hilton Garden Inn Florence

2671 Hospitality Boulevard Florence, SC

Guests bound for Syracuse can relax in soft comfort at Hilton Garden Inn Florence, where rooms start at $125.99, creating a welcoming environment ideal for unwinding. Enjoy the social atmosphere of Hilton Garden Inn's communal dining areas, perfect for sharing meals and experiences with other guests.

At Hilton Garden Inn Florence, guests can enjoy the calm and comfort of staying a bit further out, with downtown Syracuse still easily accessible by car. Make your Syracuse experience stress-free with a hotel that offers unbeatable value—book today!

  Call (855) 234-7135 to book with an agent.
  8.1 miles from Syracuse, SC 29532

Starting at

$125.99

per night

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Residence Inn Marriott Florence

2660 Hospitality Blvd Florence, SC

Encounter a enchanting stay at Residence Inn Marriott Florence as you explore Syracuse, where restful accommodations create a comfortable retreat, with rates beginning at $214.99. Relax in plush living areas at Residence Inn, designed for comfort and equipped with modern conveniences.

With a brief drive into downtown Syracuse, guests at Residence Inn Marriott Florence can explore the city’s top spots while retreating to a peaceful environment afterward. Take advantage of Syracuse lodging that prioritizes your comfort and relaxation—book today!

  Call (855) 233-0132 to book with an agent.
  8.1 miles from Syracuse, SC 29532

Starting at

$214.99

per night

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Red Roof Inn Florence Civic Center

2690 David H McLeod Boulevard Florence, SC

For guests headed to Syracuse, Red Roof Inn Florence Civic Center provides inviting accommodations with rooms starting at $69.00, creating a warm and welcoming atmosphere for relaxation. Step into a world of practical comfort at Red Roof Inn, where every aspect of your stay is designed with your convenience in mind.

Guests at Red Roof Inn Florence Civic Center will love the quiet setting of the hotel, with downtown Syracuse still a short drive away for easy city exploration. Choose a budget-friendly hotel with added comfort for your Syracuse adventure—book now!

  Call (855) 233-0132 to book with an agent.
  8.2 miles from Syracuse, SC 29532

Starting at

$69.00

per night

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TownePlace Suites by Marriott Florence

2650 Hospitality Boulevard Florence, SC

At TownePlace Suites by Marriott Florence, guests visiting Syracuse can enjoy inviting accommodations with rates beginning at $224.99, creating a gentle and welcoming space. Eco-friendly practices at TownePlace Suites include recycling and energy-efficient appliances in every suite.

With Syracuse a drive away, guests at TownePlace Suites by Marriott Florence can explore the city’s highlights while enjoying the hotel’s quieter, more serene setting. Stay smart and relaxed in Syracuse with a hotel that checks every box—book today!

  Call (855) 236-8982 to book with an agent.
  8.3 miles from Syracuse, SC 29532

Starting at

$224.99

per night

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Fairfield Inn & Suites by Marriott Florence I-20

501 Woody Jones Boulevard Florence, SC

Guests traveling to Syracuse can unwind at Fairfield Inn & Suites by Marriott Florence I-20, where budget-friendly rooms start at $179.99, creating a warm, inviting atmosphere ideal for rest. Keep your workout routine on track in Fairfield's state-of-the-art fitness centers, offering a range of equipment for all levels of activity.

At Fairfield Inn & Suites by Marriott Florence I-20, guests can enjoy the relaxed atmosphere of being further out, with downtown Syracuse still within easy reach by car. Settle in and enjoy your Syracuse stay with amenities that make all the difference—reserve now!

  Call (855) 234-5074 to book with an agent.
  8.4 miles from Syracuse, SC 29532

Starting at

$179.99

per night

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Tru by Hilton Florence I-95

2140 West Lucas Street Florence, SC

With budget-conscious rooms beginning at $138.99, Tru by Hilton Florence I-95 provides soft accommodations for travelers bound for Syracuse, creating a warm environment. Experience the convenience of Tru by Hilton’s grab-and-go dining options, perfect for busy travelers on the move.

From Tru by Hilton Florence I-95, the drive to downtown Syracuse is straightforward, allowing guests to enjoy the city’s top attractions without the noise of staying in the center. Relax and rejuvenate in Syracuse with accommodations that fit your budget perfectly—lock in today!

  Call (855) 233-0132 to book with an agent.
  9.2 miles from Syracuse, SC 29532

Starting at

$138.99

per night

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Microtel Inn & Suites by Wyndham Florence

1912 Enterprise Dr Florence, SC

With rooms beginning at $77.99, Microtel Inn & Suites by Wyndham Florence offers inviting accommodations for travelers visiting Syracuse, creating a comfortable and welcoming space for all guests. Unwind at the end of the day with Microtel's in-room entertainment options, including flat-screen TVs and cable channels.

At Microtel Inn & Suites by Wyndham Florence, visitors can enjoy the calm of staying outside the city center, while downtown Syracuse remains within reach for easy exploration. Plan your Syracuse adventure with comfort and affordability in mind—book now!

  Call (855) 239-4019 to book with an agent.
  9.2 miles from Syracuse, SC 29532

Starting at

$77.99

per night

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Comfort Suites Florence I-95

2120 West Lucas Street Florence, SC

At Comfort Suites Florence I-95, travelers to Syracuse can unwind in comforting comfort with rooms beginning at $141.99, creating a warm and inviting space ideal for relaxation. Indulge in a peaceful night's sleep on plush bedding in the quiet and comfortable suites of Comfort Suites.

At Comfort Suites Florence I-95, guests can appreciate the balance of city convenience and a more peaceful, spacious stay, with downtown Syracuse still within reach. Take advantage of a Syracuse hotel that keeps both quality and cost in mind—reserve now!

  Call (855) 234-5074 to book with an agent.
  9.3 miles from Syracuse, SC 29532

Starting at

$141.99

per night

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Sleep Inn Florence North

1833 Florence Park Dr Florence, SC

With rooms beginning at $73.99, Sleep Inn Florence North is a practical choice for travelers visiting Syracuse, creating a cozy-like and comfortable space ideal for rest. Stay in shape at Sleep Inn’s fitness centers, where you’ll find modern equipment and a welcoming environment for your workout routines.

Guests at Sleep Inn Florence North can appreciate the best of both worlds—proximity to downtown Syracuse for sightseeing, and a quiet retreat afterward. Uncover value-driven comfort that makes Syracuse travel easy—book your stay today!

  Call (855) 233-0132 to book with an agent.
  9.3 miles from Syracuse, SC 29532

Starting at

$73.99

per night

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Hampton Inn & Suites Florence North I-95

1735 Stokes Road Florence, SC

With affordable rooms beginning at $134.99, Hampton Inn & Suites Florence North I-95 provides inviting accommodations for guests visiting Syracuse, creating a warm, comfortable space. Relax in Hampton's seasonal outdoor pools, the perfect spot to cool off and enjoy some leisure time during your stay.

Guests staying at Hampton Inn & Suites Florence North I-95 will appreciate the balance of being near downtown Syracuse, while enjoying a quieter, more peaceful retreat afterward. Step into a welcoming Syracuse stay that delivers on both comfort and savings—lock in today!

  Call (855) 236-8982 to book with an agent.
  9.3 miles from Syracuse, SC 29532

Starting at

$134.99

per night

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Days Inn by Wyndham Florence / I-95 North

2111 West Lucas St. / I 95 Florence, SC

With budget-friendly rooms beginning at $68.99, Days Inn by Wyndham Florence / I-95 North provides inviting accommodations for travelers to Syracuse, creating a comfortable and welcoming space. Stay refreshed with Days Inn's in-room refrigerators and microwaves, available in select rooms for your convenience.

Guests at Days Inn by Wyndham Florence / I-95 North can enjoy a spacious, relaxing stay while still having the convenience of downtown Syracuse just a drive away. Make the most of your Syracuse travels with budget-friendly, relaxing accommodations—reserve now!

  Call (855) 236-8982 to book with an agent.
  9.3 miles from Syracuse, SC 29532

Starting at

$68.99

per night

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