The best deals on hotels when visiting Wiles Crossroads in South Carolina.

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Top 24 Hotels In Wiles Crossroads, South Carolina 29135

SpringHill Suites by Marriott Orangeburg

675 Citadel Rd Orangeburg, SC

For a comfortable stay, SpringHill Suites by Marriott Orangeburg offers inviting rooms with rates beginning at $179.99, creating a warm and inviting space ideal for travelers visiting Wiles Crossroads. The suites at SpringHill Suites are thoughtfully designed with separate zones for sleeping, working, and lounging.

For a restful escape, SpringHill Suites by Marriott Orangeburg offers serene surroundings while keeping downtown Wiles Crossroads within reach for city exploration. Take your Wiles Crossroads experience up a notch with well-appointed, wallet-friendly lodging—secure now!

  Call (855) 235-6136 to book with an agent.
  13.9 miles from Wiles Crossroads, SC 29135

Starting at

$179.99

per night

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Sleep Inn Orangeburg

3689 Saint Matthews Rd Orangeburg, SC

For budget-conscious travelers visiting Wiles Crossroads, Sleep Inn Orangeburg offers inviting accommodations with rates beginning at $130.99, creating a clean and comfortable space. Navigate your travels with ease, thanks to the local area guides and tips provided by Sleep Inn's knowledgeable staff.

Guests at Sleep Inn Orangeburg will love the quiet atmosphere, with downtown Wiles Crossroads remaining nearby for easy access to sightseeing. Treat yourself to a Wiles Crossroads stay where comfort and affordability meet—reserve your room now!

  Call (855) 236-8982 to book with an agent.
  13.9 miles from Wiles Crossroads, SC 29135

Starting at

$130.99

per night

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Holiday Inn Express & Suites Orangeburg

118 Sleep Inn Road Orangeburg, SC

At Holiday Inn Express & Suites Orangeburg, travelers visiting Wiles Crossroads can enjoy calm accommodations with rooms from $154.00, creating a warm, inviting space perfect for relaxation. Enjoy the simplicity and convenience of Holiday Inn Express's buffet dining, featuring a variety of options to suit all tastes.

At Holiday Inn Express & Suites Orangeburg, guests can relax in serene surroundings, with downtown Wiles Crossroads still a convenient drive away for a day of adventure. Relax in Wiles Crossroads with accommodations that make your stay unforgettable—secure now!

  Call (855) 234-5074 to book with an agent.
  14.0 miles from Wiles Crossroads, SC 29135

Starting at

$154.00

per night

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Tru by Hilton Orangeburg

739 Citadel Road Orangeburg, SC

For a comfortable and budget-friendly experience, Tru by Hilton Orangeburg offers enveloping rooms with rates starting at $158.99, creating a warm environment perfect for rest. Relax in Tru by Hilton’s efficiently designed rooms, where modern style and comfort are optimized for both business and leisure travelers.

Rest in the quiet setting of Tru by Hilton Orangeburg, with downtown Wiles Crossroads still accessible for a blend of rest and city adventure. Take comfort in knowing your Wiles Crossroads stay is both cozy and budget-friendly—reserve today!

  Call (855) 234-2997 to book with an agent.
  14.1 miles from Wiles Crossroads, SC 29135

Starting at

$158.99

per night

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Suburban Studios

3671 Saint Matthews Road Orangeburg, SC

At Suburban Studios, travelers to Wiles Crossroads can enjoy inviting accommodations with rooms starting at $75.99, creating a warm, welcoming space ideal for relaxation. Enjoy standard amenities in rooms that provide a comfortable environment for a budget-friendly stay.

Relax in the calm environment of Suburban Studios, where guests can enjoy a peaceful retreat and downtown Wiles Crossroads is still within reach. Make the most of your Wiles Crossroads travels with budget-friendly, relaxing accommodations—reserve now!

  Call (855) 234-5074 to book with an agent.
  14.1 miles from Wiles Crossroads, SC 29135

Starting at

$75.99

per night

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Days Inn by Wyndham Orangeburg

3691 Saint Matthews Rd Orangeburg, SC

Guests traveling to Wiles Crossroads will find delightful accommodations at Days Inn by Wyndham Orangeburg, with rooms starting at $93.99, creating a warm and inviting environment ideal for relaxation. Start each morning refreshed with a varied and satisfying breakfast, setting you up perfectly for the day ahead.

At Days Inn by Wyndham Orangeburg, guests can relax in serene surroundings, with the energy of downtown Wiles Crossroads still accessible by car for a day of exploration. Book an inviting, cost-conscious hotel for your Wiles Crossroads adventure—lock in today!

  Call (855) 239-5277 to book with an agent.
  14.1 miles from Wiles Crossroads, SC 29135

Starting at

$93.99

per night

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Quality Inn & Suites

3671 Saint Matthews Rd Orangeburg, SC

For a charming stay, Quality Inn & Suites offers budget-conscious accommodations with rates from $113.99, creating a clean, welcoming environment ideal for travelers. Start your day strong with Quality Inn's complimentary hot breakfast, offering everything from eggs and waffles to healthy options.

Guests at Quality Inn & Suites can rest in quiet surroundings, while downtown Wiles Crossroads remains nearby for a day of city exploration. Make Wiles Crossroads travel simple with a hotel that provides convenience and savings—reserve now!

  Call (855) 233-7850 to book with an agent.
  14.2 miles from Wiles Crossroads, SC 29135

Starting at

$113.99

per night

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Travelodge by Wyndham Orangeburg

3620 Saint Matthews Rd Orangeburg, SC

Guests traveling to Wiles Crossroads will find gentle comfort at Travelodge by Wyndham Orangeburg, with rooms starting at $94.05, creating a clean and inviting space perfect for rest. Benefit from Travelodge's pet-friendly accommodations, where your best friend is always welcome to join in on the fun.

Travelers seeking a peaceful getaway will love Travelodge by Wyndham Orangeburg, with its serene surroundings and easy access to downtown Wiles Crossroads. Plan your Wiles Crossroads getaway with a welcoming, budget-friendly hotel—book today!

  Call (855) 239-5277 to book with an agent.
  14.2 miles from Wiles Crossroads, SC 29135

Starting at

$94.05

per night

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Super 8 by Wyndham Orangeburg

3608 Saint Matthews Rd Orangeburg, SC

For a tranquil stay, Super 8 by Wyndham Orangeburg offers budget-friendly rooms with rates beginning at $80.00, creating a warm and welcoming environment ideal for guests visiting Wiles Crossroads. Maintain your connectivity seamlessly at Super 8, where free Wi-Fi keeps you in touch with colleagues, friends, and family.

At Super 8 by Wyndham Orangeburg, guests can unwind in peaceful surroundings, while knowing downtown Wiles Crossroads remains within easy driving distance. Plan your Wiles Crossroads adventure with ease and savings—secure your hotel today!

  Call (855) 235-6136 to book with an agent.
  14.2 miles from Wiles Crossroads, SC 29135

Starting at

$80.00

per night

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Baymont by Wyndham Orangeburg North

3583 Saint Matthews Rd Orangeburg, SC

Guests headed to Wiles Crossroads will appreciate the enchanting comfort at Baymont by Wyndham Orangeburg North, where rooms start at $96.99, creating a clean, welcoming environment for relaxation. Relax with the convenience of Baymont by Wyndham’s on-demand movies, available in all guest rooms.

For a calm escape, Baymont by Wyndham Orangeburg North offers peaceful surroundings, while downtown Wiles Crossroads is still close enough for city exploration. Escape to Wiles Crossroads with budget-wise lodging that offers more—book your stay now!

  Call (855) 235-6136 to book with an agent.
  14.3 miles from Wiles Crossroads, SC 29135

Starting at

$96.99

per night

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Comfort Inn & Suites

746 Citadel Rd Orangeburg, SC

With affordable rooms starting at $171.99, Comfort Inn & Suites provides mellifluous accommodations for travelers bound for Wiles Crossroads, creating a clean, inviting space. Experience the friendly service of Comfort Inn's staff, always ready to assist and make your stay more enjoyable.

Travelers seeking a peaceful getaway will love Comfort Inn & Suites, with its serene surroundings and easy access to downtown Wiles Crossroads. Make every moment in Wiles Crossroads memorable with a hotel that offers budget-friendly perks—reserve now!

  Call (855) 234-2997 to book with an agent.
  14.4 miles from Wiles Crossroads, SC 29135

Starting at

$171.99

per night

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Fairfield Inn by Marriott Orangeburg

663 Citadel Road Orangeburg, SC

At Fairfield Inn by Marriott Orangeburg, guests bound for Wiles Crossroads will enjoy budget-friendly comfort with rooms starting at $199.99, creating a warm and welcoming atmosphere. Indulge in Fairfield’s bakery corner, featuring fresh pastries and breads baked daily on the premises.

At Fairfield Inn by Marriott Orangeburg, visitors can unwind in peaceful surroundings, while the excitement of downtown Wiles Crossroads is still within driving distance. Embrace a worry-free Wiles Crossroads adventure with practical, inviting lodging—reserve your room now!

  Call (855) 233-7850 to book with an agent.
  14.4 miles from Wiles Crossroads, SC 29135

Starting at

$199.99

per night

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Days Inn by Wyndham Orangeburg South

3402 Five Chop Rd Orangeburg, SC

For budget-conscious guests bound for Wiles Crossroads, Days Inn by Wyndham Orangeburg South provides affordable comfort with rooms starting at $88.99, creating a delightful space perfect for unwinding. Relax in Days Inn's modern lobbies, perfect spaces for reading, working, or planning your day's activities.

For those looking for relaxation, Days Inn by Wyndham Orangeburg South provides peaceful surroundings with downtown Wiles Crossroads still accessible for sightseeing. Choose a hotel that adds value to your Wiles Crossroads adventure—book your stay now!

  Call (855) 233-0132 to book with an agent.
  17.4 miles from Wiles Crossroads, SC 29135

Starting at

$88.99

per night

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Quality Inn & Suites

8929 Old Number Six Highway Santee, SC

With budget-conscious rooms beginning at $75.99, Quality Inn & Suites is a practical choice for travelers to Wiles Crossroads, providing a warm and inviting space ideal for rest. Enjoy the flexibility of Quality Inn's 24-hour cancellation policy, offering peace of mind for your travel plans.

At Quality Inn & Suites, guests can enjoy the calm atmosphere, while downtown Wiles Crossroads is still nearby for a day of city exploration. Take advantage of a Wiles Crossroads hotel that keeps both quality and cost in mind—reserve now!

  Call (855) 234-5074 to book with an agent.
  18.9 miles from Wiles Crossroads, SC 29135

Starting at

$75.99

per night

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Red Roof Inn Santee

9091 Old Highway 6 Santee, SC

For a restful and affordable stay, Red Roof Inn Santee offers inviting rooms with rates starting at $81.99, creating a quiet and comfortable space ideal for travelers bound for Wiles Crossroads. Rest with ease at Red Roof Inn, knowing the dedicated staff are always available to address your needs and ensure a pleasant stay.

Rest easy at Red Roof Inn Santee, where peaceful surroundings create a calming retreat, while downtown Wiles Crossroads remains within driving distance. Enjoy added perks and affordable rates on your Wiles Crossroads trip—book your room today!

  Call (855) 234-5074 to book with an agent.
  19.0 miles from Wiles Crossroads, SC 29135

Starting at

$81.99

per night

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Comfort Inn & Suites Santee

221 Britain St Santee, SC

With rooms beginning at $135.99, Comfort Inn & Suites Santee provides budget-friendly accommodations for travelers visiting Wiles Crossroads, creating a warm and welcoming environment. Trust in Comfort Inn for a reliable and comfortable stay, where guest needs are anticipated and met with care.

Guests at Comfort Inn & Suites Santee will appreciate the peaceful surroundings, while downtown Wiles Crossroads remains nearby for city adventures. Make the most of your Wiles Crossroads adventure with accommodations that prioritize savings—lock in now!

  Call (855) 239-5277 to book with an agent.
  19.0 miles from Wiles Crossroads, SC 29135

Starting at

$135.99

per night

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Holiday Inn Santee an IHG Hotel

139 Bradford Blvd Santee, SC

Choose Holiday Inn Santee an IHG Hotel for a restful escape on your visit to Wiles Crossroads, where inviting accommodations start at a reasonable $155.00 per night, perfect for relaxation. Experience the local vibe with Holiday Inn's seasonal festivals, celebrating everything from food and wine to music and art.

Guests staying at Holiday Inn Santee an IHG Hotel will appreciate the balance of easy city access and the calming retreat offered by the hotel. Uncover the perfect blend of quality and savings in Wiles Crossroads—book your hotel room today!

  Call (855) 234-7135 to book with an agent.
  19.0 miles from Wiles Crossroads, SC 29135

Starting at

$155.00

per night

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Baymont by Wyndham Santee

249 Britain Street Santee, SC

Guests traveling to Wiles Crossroads will find alluring accommodations at Baymont by Wyndham Santee, with rooms starting at $92.99, creating a warm and welcoming atmosphere. Experience the ease of travel with Baymont by Wyndham’s shuttle services, available to transport you to local airports and attractions.

Guests at Baymont by Wyndham Santee will appreciate the calm retreat, with downtown Wiles Crossroads remaining within easy reach for city exploration. Enjoy a Wiles Crossroads stay where comfort is never compromised—secure your room now!

  Call (855) 234-2997 to book with an agent.
  19.1 miles from Wiles Crossroads, SC 29135

Starting at

$92.99

per night

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Tru by Hilton Santee

263 Britain St. & 273 Britain St. Santee, SC

Guests visiting Wiles Crossroads will find peaceful accommodations at Tru by Hilton Santee, with rooms starting at $154.99, creating a warm and inviting environment ideal for relaxation. Stay informed with Tru by Hilton’s touchscreen panels in the lobby, offering local information, weather updates, and hotel services.

Guests at Tru by Hilton Santee can enjoy quiet surroundings, with the added convenience of downtown Wiles Crossroads being just a drive away. Choose a Wiles Crossroads hotel that turns your trip into a seamless, budget-friendly experience—reserve now!

  Call (855) 235-6136 to book with an agent.
  19.1 miles from Wiles Crossroads, SC 29135

Starting at

$154.99

per night

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Best Western Plus Santee Inn

I 95 Exit 98 Santee, SC

For a comfortable stay, Best Western Plus Santee Inn offers budget-friendly rooms with rates beginning at $125.99, creating a clean and inviting space ideal for relaxation. Stay energized with the snack bars available at Best Western Plus, offering a selection of healthy and satisfying options.

With a relaxing drive into downtown Wiles Crossroads, guests at Best Western Plus Santee Inn can explore the city’s best spots while retreating to the peace and quiet of their stay. Discover how great your Wiles Crossroads visit can be with thoughtfully priced lodging—lock in today!

  Call (855) 233-0132 to book with an agent.
  19.4 miles from Wiles Crossroads, SC 29135

Starting at

$125.99

per night

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Hampton Inn Santee I-95

9060 Old Number Six Hwy Santee, SC

With rooms starting at $153.99, Hampton Inn Santee I-95 provides affordable accommodations for travelers visiting Wiles Crossroads, creating a comfy and comfortable atmosphere. Navigate your travels with ease from Hampton's locations, ideally situated to connect you with the area's transportation hubs.

For those who prefer a calm atmosphere, Hampton Inn Santee I-95 offers tranquility while keeping downtown Wiles Crossroads close enough for a day of adventure. Treat yourself to a Wiles Crossroads stay that blends convenience with budget-friendly rates—book now!

  Call (855) 234-7135 to book with an agent.
  19.4 miles from Wiles Crossroads, SC 29135

Starting at

$153.99

per night

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Orangeburg Inn & Suites

1415 John C Calhoun Dr Orangeburg, SC

For an inviting stay near Wiles Crossroads, Orangeburg Inn & Suites offers affordable comfort with rates from $60.99, creating a clean, delightful space for unwinding and rest. Relax in a practical space that offers basic comforts and a clean environment, making your stay both pleasant and affordable.

Guests staying at Orangeburg Inn & Suites can enjoy a quiet retreat, with downtown Wiles Crossroads just a short drive away for sightseeing or city adventures. Choose comfort and affordability for your Wiles Crossroads stay—book your room today!

  Call (855) 239-4019 to book with an agent.
  19.4 miles from Wiles Crossroads, SC 29135

Starting at

$60.99

per night

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Fairfield Inn & Suites by Marriott Santee

9074 Old Number Six Hwy Santee, SC

With rooms beginning at $159.99, Fairfield Inn & Suites by Marriott Santee offers inviting accommodations for travelers visiting Wiles Crossroads, creating a pleasant, comfortable space for rest. Experience the convenience of Fairfield's touchless systems, from check-in to room controls, ensuring a hygienic and modern stay.

Guests staying at Fairfield Inn & Suites by Marriott Santee will enjoy the calm setting, with the excitement of downtown Wiles Crossroads still a smooth drive away. Stay relaxed and on budget while exploring Wiles Crossroads with thoughtfully designed lodging—lock in today!

  Call (855) 236-8982 to book with an agent.
  19.4 miles from Wiles Crossroads, SC 29135

Starting at

$159.99

per night

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Econo Lodge

9112 Old 6 Highway Santee, SC

With rooms from $72.99, Econo Lodge provides cushy, budget-conscious comfort for travelers bound for Wiles Crossroads, creating a clean and welcoming environment. Relax with the knowledge that many Econo Lodge locations offer smoke-free rooms, providing a clean and fresh environment.

Guests can unwind in the tranquil setting of Econo Lodge, while the excitement of downtown Wiles Crossroads is just a drive away. Book an inviting hotel that won’t strain your budget for your Wiles Crossroads trip—secure today!

  Call (855) 234-7135 to book with an agent.
  19.5 miles from Wiles Crossroads, SC 29135

Starting at

$72.99

per night

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